Real-Time Monitoring of Human Guanine Deaminase Activity by an Emissive Guanine Analog.
Journal
ACS chemical biology
ISSN: 1554-8937
Titre abrégé: ACS Chem Biol
Pays: United States
ID NLM: 101282906
Informations de publication
Date de publication:
16 07 2021
16 07 2021
Historique:
pubmed:
1
7
2021
medline:
5
10
2021
entrez:
30
6
2021
Statut:
ppublish
Résumé
Guanine deaminase (GDA) deaminates guanine to xanthine. Despite its significance, the study of human GDA remains limited compared to other metabolic deaminases. As a result, its substrate and inhibitor repertoire are limited, and effective real-time activity, inhibitory, and discovery assays are missing. Herein, we explore two emissive heterocyclic cores, based on thieno[3,4-
Identifiants
pubmed: 34190533
doi: 10.1021/acschembio.1c00232
pmc: PMC9109600
mid: NIHMS1802979
doi:
Substances chimiques
Enzyme Inhibitors
0
Fluorescent Dyes
0
Pyrimidines
0
Thiazoles
0
Thiophenes
0
Guanine Deaminase
EC 3.5.4.3
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1208-1214Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM069773
Pays : United States
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