High-Resolution Human Kidney Molecular Histology by Imaging Mass Spectrometry of Lipids.
Journal
Analytical chemistry
ISSN: 1520-6882
Titre abrégé: Anal Chem
Pays: United States
ID NLM: 0370536
Informations de publication
Date de publication:
13 07 2021
13 07 2021
Historique:
pubmed:
1
7
2021
medline:
22
7
2021
entrez:
30
6
2021
Statut:
ppublish
Résumé
For many years, traditional histology has been the gold standard for the diagnosis of many diseases. However, alternative and powerful techniques have appeared in recent years that complement the information extracted from a tissue section. One of the most promising techniques is imaging mass spectrometry applied to lipidomics. Here, we demonstrate the capabilities of this technique to highlight the architectural features of the human kidney at a spatial resolution of 10 μm. Our data demonstrate that up to seven different segments of the nephron and the interstitial tissue can be readily identified in the sections according to their characteristic lipid fingerprints and that such fingerprints are maintained among different individuals (
Identifiants
pubmed: 34192457
doi: 10.1021/acs.analchem.1c00649
pmc: PMC8922278
doi:
Substances chimiques
Lipids
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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