Mucin Binding to

Humans Inflammation Lung / metabolism Moraxella catarrhalis / metabolism Mucin-5B / metabolism Pulmonary Disease, Chronic Obstructive / metabolism Respiratory Mucosa / metabolism Sialic Acids / metabolism
COPD Moraxella catarrhalis host–pathogen interaction mucin sialic acid

Journal

American journal of respiratory cell and molecular biology
ISSN: 1535-4989
Titre abrégé: Am J Respir Cell Mol Biol
Pays: United States
ID NLM: 8917225

Informations de publication

Date de publication:
12 2021
Historique:
pubmed: 1 7 2021
medline: 24 12 2021
entrez: 30 6 2021
Statut: ppublish

Résumé

Chronic obstructive pulmonary disease (COPD) is associated with colonization by bacterial pathogens and repeated airway infections, leading to exacerbations and impaired lung function. The highly glycosylated mucins in the mucus lining the airways are an important part of the host defense against pathogens. However, mucus accumulation can contribute to COPD pathology. Here, we examined whether inflammation is associated with glycosylation changes that affect interactions between airway mucins and pathogens. We isolated mucins from lower airway samples (

Identifiants

DOI: 10.1165/rcmb.2021-0064OC PMID: 34192508
pubmed: 34192508
doi: 10.1165/rcmb.2021-0064OC
doi:

Substances chimiques

MUC5B protein, human 0
Mucin-5B 0
Sialic Acids 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

593-602

Auteurs

Médea Padra (M)

Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine.

John Benktander (J)

Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine.

János T Padra (JT)

Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine.

Anders Andersson (A)

Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, and.
COPD Center, Department of Respiratory Medicine and Allergology, Sahlgrenska University Hospital, Gothenburg, Sweden.

Bettina Brundin (B)

Unit for Lung and Airway Research, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Sara Tengvall (S)

Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, and.

Karin Christenson (K)

Department of Oral Microbiology and Immunology, Institute of Odontology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Ingemar Qvarfordt (I)

Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, and.

Robert Gad (R)

Department of Anesthesiology and Intensive Care, and.

Magnus Paulsson (M)

Department of Infectious Diseases, Skåne University Hospital, Lund; Sweden.
Translational Infection Medicine, Lund University, Lund, Sweden; and.

Nikolaos Pournaras (N)

Unit for Lung and Airway Research, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Karolinska Severe COPD Center, Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden.

Anders Lindén (A)

Unit for Lung and Airway Research, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Karolinska Severe COPD Center, Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden.

Sara K Lindén (SK)

Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine.
ORCID: 0000-0002-7751-9586

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Mucin Binding to
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Mucin Binding to
questionsmedicales.fr › Appareil respiratoire › Poumon › Mucin Binding to
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Moraxellaceae › Moraxella › Moraxella (Branhamella) catarrhalis › Mucin Binding to
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides salivaires › Mucine 5B › Mucin Binding to
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie chronique › Broncho-pneumopathie chronique obstructive › Mucin Binding to
questionsmedicales.fr › Tissus › Membranes › Muqueuse › Muqueuse respiratoire › Mucin Binding to
questionsmedicales.fr › Glucides › Oses acides › Acides neuraminiques › Acides sialiques › Mucin Binding to