An Early Cortical Progenitor-Specific Mechanism Regulates Thalamocortical Innervation.


Journal

The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140

Informations de publication

Date de publication:
11 08 2021
Historique:
received: 27 01 2021
revised: 29 05 2021
accepted: 08 06 2021
pubmed: 2 7 2021
medline: 23 11 2021
entrez: 1 7 2021
Statut: ppublish

Résumé

The cortical subplate is critical in regulating the entry of thalamocortical sensory afferents into the cortex. These afferents reach the subplate at embryonic day (E)15.5 in the mouse, but "wait" for several days, entering the cortical plate postnatally. We report that when transcription factor LHX2 is lost in E11.5 cortical progenitors, which give rise to subplate neurons, thalamocortical afferents display premature, exuberant ingrowth into the E15.5 cortex. Embryonic mutant subplate neurons are correctly positioned below the cortical plate, but they display an altered transcriptome and immature electrophysiological properties during the waiting period. The sensory thalamus in these cortex-specific

Identifiants

pubmed: 34193558
pii: JNEUROSCI.0226-21.2021
doi: 10.1523/JNEUROSCI.0226-21.2021
pmc: PMC8360687
doi:

Substances chimiques

LIM-Homeodomain Proteins 0
Lhx2 protein, mouse 0
Transcription Factors 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

6822-6835

Subventions

Organisme : Wellcome Trust
Pays : United Kingdom

Informations de copyright

Copyright © 2021 the authors.

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Auteurs

Suranjana Pal (S)

Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, 400005, India.

Deepanjali Dwivedi (D)

National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bengaluru, 560001, India.

Tuli Pramanik (T)

Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, 400005, India.

Geeta Godbole (G)

Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, 400005, India.

Takuji Iwasato (T)

Laboratory of Mammalian Neural Circuits, National Institute of Genetics, Mishima, 411-8540, Japan.
Department of Genetics, SOKENDAI (Graduate University for Advanced Studies), Mishima, 411-8540, Japan.

Denis Jabaudon (D)

Department of Basic Neurosciences, University of Geneva, 1211 Geneva, Switzerland; Department of Neurology, Geneva University Hospital, 1205 Geneva, Switzerland.

Upinder S Bhalla (US)

National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bengaluru, 560001, India.

Shubha Tole (S)

Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, 400005, India shubhatole@gmail.com.

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Classifications MeSH