cAMP binding to closed pacemaker ion channels is non-cooperative.


Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
07 2021
Historique:
received: 20 10 2020
accepted: 02 06 2021
pubmed: 2 7 2021
medline: 12 1 2022
entrez: 1 7 2021
Statut: ppublish

Résumé

Electrical activity in the brain and heart depends on rhythmic generation of action potentials by pacemaker ion channels (HCN) whose activity is regulated by cAMP binding

Identifiants

pubmed: 34194042
doi: 10.1038/s41586-021-03686-x
pii: 10.1038/s41586-021-03686-x
pmc: PMC8513821
mid: NIHMS1715247
doi:

Substances chimiques

Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels 0
Ligands 0
Protein Isoforms 0
Cyclic AMP E0399OZS9N

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

606-610

Subventions

Organisme : NINDS NIH HHS
ID : R01 NS081293
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS101723
Pays : United States
Organisme : NINDS NIH HHS
ID : R35 NS116850
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007507
Pays : United States

Informations de copyright

© 2021. The Author(s), under exclusive licence to Springer Nature Limited.

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Auteurs

David S White (DS)

Department of Neuroscience, University of Wisconsin-Madison, Madison, WI, USA.
Department of Chemistry, University of Wisconsin-Madison, Madison, WI, USA.
Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.

Sandipan Chowdhury (S)

Department of Neuroscience, University of Wisconsin-Madison, Madison, WI, USA.
Department of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, IA, USA.

Vinay Idikuda (V)

Department of Neuroscience, University of Wisconsin-Madison, Madison, WI, USA.
Center for Investigation of Membrane Excitability Diseases, Department of Anesthesiology, Washington University School of Medicine, St Louis, MO, USA.

Ruohan Zhang (R)

Department of Neuroscience, University of Wisconsin-Madison, Madison, WI, USA.
Department of Chemistry, University of Wisconsin-Madison, Madison, WI, USA.

Scott T Retterer (ST)

Center for Nanophase Materials Sciences, Oak Ridge National Laboratory, Oak Ridge, TN, USA.

Randall H Goldsmith (RH)

Department of Chemistry, University of Wisconsin-Madison, Madison, WI, USA. rhg@chem.wisc.edu.

Baron Chanda (B)

Department of Neuroscience, University of Wisconsin-Madison, Madison, WI, USA. bchanda@wustl.edu.
Center for Investigation of Membrane Excitability Diseases, Department of Anesthesiology, Washington University School of Medicine, St Louis, MO, USA. bchanda@wustl.edu.

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Classifications MeSH