Actualities in immunological markers and electrochemical sensors for determination of dopamine and its metabolites in psychotic disorders (Review).

dopamine electrochemical sensor immunology psychosis schizophrenia voltammetry

Journal

Experimental and therapeutic medicine
ISSN: 1792-1015
Titre abrégé: Exp Ther Med
Pays: Greece
ID NLM: 101531947

Informations de publication

Date de publication:
Aug 2021
Historique:
received: 27 04 2021
accepted: 26 05 2021
entrez: 1 7 2021
pubmed: 2 7 2021
medline: 2 7 2021
Statut: ppublish

Résumé

Psychotic disorders represent a serious health concern. At this moment, anamnestic data, international criteria for diagnosis/classification from the Diagnostic and Statistical Manual of Mental Disorders-5 and the International Classification of Diseases-10 and diagnostic scales are used to establish a diagnosis. The most commonly used biomarkers in psychotic illnesses are those regarding the neuroimmune system, metabolic abnormalities, neurotrophins and neurotransmitter systems and proteomics. A current issue faced by clinicians is the lack of biomarkers to help develop a more accurate diagnosis, with the possibility of initiating the most effective treatment. The detection of biological markers for psychosis has the potential to contribute to improvements in its diagnosis, prognosis and treatment effectiveness. The mixture of multiple biomarkers may improve the ability to differentiate and classify these patients. In this sense, the aim of this study was to analyze the literature concerning the potential biomarkers that could be used in medical practice and to review the newest developments in electrochemical sensors used for dopamine detection, one of the most important exploited biomarkers.

Identifiants

pubmed: 34194566
doi: 10.3892/etm.2021.10320
pii: ETM-0-0-10320
pmc: PMC8237259
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

888

Informations de copyright

Copyright: © Ciobanu et al.

Déclaration de conflit d'intérêts

The authors declare that they have no competing interests.

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Auteurs

Adela Magdalena Ciobanu (AM)

Department of Psychiatry, 'Prof. Dr. Alexandru Obregia' Clinical Psychiatric Hospital, 041914 Bucharest, Romania.
Discipline of Psychiatry, Neurosciences Department, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.

Luana Geza (L)

Department of Psychiatry, 'Prof. Dr. Alexandru Obregia' Clinical Psychiatric Hospital, 041914 Bucharest, Romania.
Discipline of Psychiatry, Neurosciences Department, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.

Iulia Gabriela David (IG)

Department of Analytical Chemistry, Faculty of Chemistry, University of Bucharest, 050663 Bucharest, Romania.

Dana Elena Popa (DE)

Department of Analytical Chemistry, Faculty of Chemistry, University of Bucharest, 050663 Bucharest, Romania.

Mihaela Buleandra (M)

Department of Analytical Chemistry, Faculty of Chemistry, University of Bucharest, 050663 Bucharest, Romania.

Anton Alexandru Ciucu (AA)

Department of Analytical Chemistry, Faculty of Chemistry, University of Bucharest, 050663 Bucharest, Romania.

Liana Dehelean (L)

Department of Neurosciences-Psychiatry, Centre for Cognitive Research in Neuropsychiatric Pathology, 'Victor Babes' University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania.

Classifications MeSH