Spectrum of Drug Resistance in Musculoskeletal Tuberculosis.
Drug-resistant tuberculosis
EPTB
GeneXpert MTB/RIF
MSK-TB
Pre-XDR
Journal
Indian journal of orthopaedics
ISSN: 0019-5413
Titre abrégé: Indian J Orthop
Pays: Switzerland
ID NLM: 0137736
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
received:
17
10
2020
accepted:
06
02
2021
entrez:
1
7
2021
pubmed:
2
7
2021
medline:
2
7
2021
Statut:
epublish
Résumé
Very few studies report resistance pattern exclusively in musculoskeletal tuberculosis (MSK-TB). This study of 100 pus samples from patients of MSK-TB with active disease in whom Among these 100 cases; 22% were AFB positive; MGIT 960 detected MTB in 58.33% (35/60) new cases and 30.0% (12/40) previously treated cases. Five new and 10 previously treated cases had drug resistance and 12 were detected rifampicin resistance (Rif-R) by CBNAAT. Among new cases MGIT-DST detected mono-INH resistant in 2.86% (1/35), mono-STR resistant in 2.86% (1/35), MDR-TB in 5.7% (2/35) and pre-XDR in 2.9%(1/35).Among previously treated cases Rif-R was found in 10% (4/40) where MTB was not detected by MGIT and MGIT-DST detected mono-INH resistant in 8.33% (1/12); MDR-TB in 8.33% (1/12) and pre-XDR in 33.3%. There were no cases of XDR-TB. High disease burden of various type drug resistance were seen more commonly in previously treated cases and was not uncommon in new cases of MSK-TB. Both CBNAAT and DST are essential for detecting resistance pattern in MSK-TB.
Sections du résumé
BACKGROUND
BACKGROUND
Very few studies report resistance pattern exclusively in musculoskeletal tuberculosis (MSK-TB).
METHODS
METHODS
This study of 100 pus samples from patients of MSK-TB with active disease in whom
RESULTS
RESULTS
Among these 100 cases; 22% were AFB positive; MGIT 960 detected MTB in 58.33% (35/60) new cases and 30.0% (12/40) previously treated cases. Five new and 10 previously treated cases had drug resistance and 12 were detected rifampicin resistance (Rif-R) by CBNAAT. Among new cases MGIT-DST detected mono-INH resistant in 2.86% (1/35), mono-STR resistant in 2.86% (1/35), MDR-TB in 5.7% (2/35) and pre-XDR in 2.9%(1/35).Among previously treated cases Rif-R was found in 10% (4/40) where MTB was not detected by MGIT and MGIT-DST detected mono-INH resistant in 8.33% (1/12); MDR-TB in 8.33% (1/12) and pre-XDR in 33.3%. There were no cases of XDR-TB.
CONCLUSION
CONCLUSIONS
High disease burden of various type drug resistance were seen more commonly in previously treated cases and was not uncommon in new cases of MSK-TB. Both CBNAAT and DST are essential for detecting resistance pattern in MSK-TB.
Identifiants
pubmed: 34194646
doi: 10.1007/s43465-021-00378-6
pii: 378
pmc: PMC8192612
doi:
Types de publication
Journal Article
Langues
eng
Pagination
907-911Informations de copyright
© Indian Orthopaedics Association 2021.
Déclaration de conflit d'intérêts
Conflict of InterestThe authors declare that they have no conflict of interest.
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