Cellular cannibalism and consequent thrombocytopenia in a patient with bone marrow metastasis of malignant pleural mesothelioma: A case report.
apoptosis
blood cells
bone marrow
cell survival
cellular cannibalism
disseminated intravascular coagulation
drug resistance
mesothelioma
metastasis
thrombocytopenia
Journal
Molecular and clinical oncology
ISSN: 2049-9469
Titre abrégé: Mol Clin Oncol
Pays: England
ID NLM: 101613422
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
received:
20
12
2020
accepted:
07
05
2021
entrez:
1
7
2021
pubmed:
2
7
2021
medline:
2
7
2021
Statut:
ppublish
Résumé
Cellular cannibalism is a tumor activity where a cell is engulfed by another cell. This process promotes tumor cell survival under unfavorable conditions. The current report describes an extremely rare case of thrombocytopenia resulting from cellular cannibalism in a patient with bone marrow metastasis due to malignant pleural mesothelioma (MPM). A 77-year-old male presented with hemothorax and thrombocytopenia. He was diagnosed with MPM of the sarcomatoid cell type. However, his disease progressed rapidly and he died 11 days after admission. Bone marrow aspiration revealed metastatic MPM cells that had engulfed other blood cells. Accordingly, the observed thrombocytopenia was attributed to cellular cannibalism by metastatic MPM tumor cells. To the best of our knowledge, this is the first reported case of thrombocytopenia due to cellular cannibalism in a patient with this type of malignancy (MPM). The results suggested that although MPM rarely metastasizes to the bone marrow, bone marrow aspiration could be useful in such cases.
Identifiants
pubmed: 34194741
doi: 10.3892/mco.2021.2325
pii: MCO-0-0-02325
pmc: PMC8237155
doi:
Types de publication
Journal Article
Langues
eng
Pagination
163Informations de copyright
Copyright: © Nishikubo et al.
Déclaration de conflit d'intérêts
The authors declare that they have no competing interests.
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