Antimicrobial Peptides: A New Hope in Biomedical and Pharmaceutical Fields.
antimicrobial peptides
biomedical and pharmacological applications
drug delivery
drug-resistant microorganisms
pharmacokinetics and pharmacodynamics
Journal
Frontiers in cellular and infection microbiology
ISSN: 2235-2988
Titre abrégé: Front Cell Infect Microbiol
Pays: Switzerland
ID NLM: 101585359
Informations de publication
Date de publication:
2021
2021
Historique:
received:
16
02
2021
accepted:
10
05
2021
entrez:
1
7
2021
pubmed:
2
7
2021
medline:
6
7
2021
Statut:
epublish
Résumé
Antibiotics are essential drugs used to treat pathogenic bacteria, but their prolonged use contributes to the development and spread of drug-resistant microorganisms. Antibiotic resistance is a serious challenge and has led to the need for new alternative molecules less prone to bacterial resistance. Antimicrobial peptides (AMPs) have aroused great interest as potential next-generation antibiotics, since they are bioactive small proteins, naturally produced by all living organisms, and representing the first line of defense against fungi, viruses and bacteria. AMPs are commonly classified according to their sources, which are represented by microorganisms, plants and animals, as well as to their secondary structure, their biosynthesis and their mechanism of action. They find application in different fields such as agriculture, food industry and medicine, on which we focused our attention in this review. Particularly, we examined AMP potential applicability in wound healing, skin infections and metabolic syndrome, considering their ability to act as potential Angiotensin-Converting Enzyme I and pancreatic lipase inhibitory peptides as well as antioxidant peptides. Moreover, we argued about the pharmacokinetic and pharmacodynamic approaches to develop new antibiotics, the drug development strategies and the formulation approaches which need to be taken into account in developing clinically suitable AMP applications.
Identifiants
pubmed: 34195099
doi: 10.3389/fcimb.2021.668632
pmc: PMC8238046
doi:
Substances chimiques
Anti-Bacterial Agents
0
Antimicrobial Cationic Peptides
0
Pharmaceutical Preparations
0
Pore Forming Cytotoxic Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
668632Informations de copyright
Copyright © 2021 Moretta, Scieuzo, Petrone, Salvia, Manniello, Franco, Lucchetti, Vassallo, Vogel, Sgambato and Falabella.
Déclaration de conflit d'intérêts
CS, RS, AF and PF were employed by Spinoff XFlies s.r.l. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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