Immunotherapies in chronic adhesive arachnoiditis - A case series and literature review.
CSAA, Chronic spinal adhesive arachnoiditis
CSF, Cerebrospinal fluid
I.v. corticosteroids
ICD, International Statistical Classification of Diseases and Related Health Problems
MCTD, Mixed connective tissue disease
MRI
MRI, Magnetic resonance imaging
Methotrexate
Neurosurgical intervention
SC, Spinal cord
Spinal cord lesions
i.v., intravenous
s.c., subcutaneous
Journal
eNeurologicalSci
ISSN: 2405-6502
Titre abrégé: eNeurologicalSci
Pays: Netherlands
ID NLM: 101667077
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
received:
26
02
2021
revised:
10
05
2021
accepted:
09
06
2021
entrez:
1
7
2021
pubmed:
2
7
2021
medline:
2
7
2021
Statut:
epublish
Résumé
Chronic spinal adhesive arachnoiditis (CSAA) is a rare condition with limited therapeutic options. Surgical treatment proves effective in approximately 60% of cases. Conservative treatment options have not been extensively investigated. Here, we report the course of the disease, analyze the effect of immune treatments in patients with CSAA who were treated in the University Hospital Essen between 2015 and 2020, and conduct a literature review. Three out of four patients showed no improvement after treatment with corticosteroids, methotrexate, or plasmapheresis. All non-responders suffered from CSAA for several years, while one patient who had a disease duration of less than one month fully recovered. It is necessary to verify whether treatment at an early stage of the disease is better than treatment after chronic adhesion manifestation, as it interrupts the development of adhesions and all subsequent complications.
Identifiants
pubmed: 34195394
doi: 10.1016/j.ensci.2021.100350
pii: S2405-6502(21)00042-3
pmc: PMC8225987
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100350Informations de copyright
© 2021 The Authors.
Déclaration de conflit d'intérêts
None.
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