The Nasal Microbiome in ANCA-Associated Vasculitis: Picking the Nose for Clues on Disease Pathogenesis.
ANCA
Autoimmune disease
Microbiome
Staphylococcus aureus
Vasculitis
Journal
Current rheumatology reports
ISSN: 1534-6307
Titre abrégé: Curr Rheumatol Rep
Pays: United States
ID NLM: 100888970
Informations de publication
Date de publication:
01 07 2021
01 07 2021
Historique:
accepted:
21
04
2021
entrez:
1
7
2021
pubmed:
2
7
2021
medline:
26
11
2021
Statut:
epublish
Résumé
The onset and progression of small vessel vasculitis associated with anti-neutrophil cytoplasmic antibodies has been linked to microbial infections. Here, we provide a brief overview of the association of nasal colonization of Staphylococcus aureus with ANCA-associated vasculitis (AAV) and discuss several recent studies mapping the nasal microbiome in AAV patients in particular. Nasal microbiome studies revealed dysbiosis as a common trait in active AAV which tends to normalize upon immunosuppressive treatment and quiescent disease. However, due to differences in study design, patient selection, and methodology, the reported microbiome profiles differ considerably precluding conclusions on causal relationships. The microbiome is an emerging area of research in AAV warranting further investigation. Ideally, such studies should be combined with mechanistic studies to unravel key elements related to host-microbe interactions and their relevance for AAV pathogenesis.
Identifiants
pubmed: 34196846
doi: 10.1007/s11926-021-01015-9
pii: 10.1007/s11926-021-01015-9
pmc: PMC8249244
doi:
Substances chimiques
Antibodies, Antineutrophil Cytoplasmic
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
54Références
N Engl J Med. 1996 Jul 4;335(1):16-20
pubmed: 8637536
Sci Rep. 2015 Feb 02;5:8188
pubmed: 25641235
Ann Rheum Dis. 2009 Jun;68(6):1067-71
pubmed: 19028765
Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13187-92
pubmed: 25161283
Rheumatology (Oxford). 2016 Jan;55(1):162-72
pubmed: 26320128
N Engl J Med. 2012 Jul 19;367(3):214-23
pubmed: 22808956
Med Hypotheses. 2018 Mar;112:24-26
pubmed: 29447930
Kidney Int. 2010 Sep;78(6):590-7
pubmed: 20592714
Rheumatology (Oxford). 2011 Apr;50(4):689-96
pubmed: 21149241
Ann Intern Med. 1994 Jan 1;120(1):12-7
pubmed: 8250451
Rhinology. 2011 Mar;49(1):107-11
pubmed: 21468384
Ann Rheum Dis. 2018 Oct;77(10):1448-1453
pubmed: 29997110
Sci Rep. 2020 Jun 11;10(1):9466
pubmed: 32528054
BMC Immunol. 2008 Jul 14;9:34
pubmed: 18625057
Nat Rev Immunol. 2017 Apr;17(4):219-232
pubmed: 28260787
Nephrol Dial Transplant. 2014 Apr;29(4):739-45
pubmed: 24398891
Nat Med. 2004 Jan;10(1):72-9
pubmed: 14661018
Sci Rep. 2017 Sep 22;7(1):12211
pubmed: 28939882
J Autoimmun. 2019 Feb;97:29-39
pubmed: 30420263
Rheumatology (Oxford). 2007 Jun;46(6):1029-33
pubmed: 17409134
Nat Rev Dis Primers. 2020 Aug 27;6(1):71
pubmed: 32855422
Nat Commun. 2019 Jul 29;10(1):3392
pubmed: 31358739
Blood. 2012 Oct 11;120(15):3007-18
pubmed: 22932797
Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):9439-9444
pubmed: 28808028
Science. 2004 Mar 5;303(5663):1532-5
pubmed: 15001782
Curr Opin Rheumatol. 2014 Jul;26(4):416-23
pubmed: 24827750
Allergy Rhinol (Providence). 2020 Mar 13;11:2152656720911605
pubmed: 32206384
Microbiome. 2019 Oct 22;7(1):137
pubmed: 31640771
Front Immunol. 2016 Nov 04;7:461
pubmed: 27867381
Best Pract Res Clin Rheumatol. 2020 Feb;34(1):101473
pubmed: 32044247
PLoS One. 2010 May 17;5(5):e10598
pubmed: 20498722
Arthritis Res Ther. 2021 Jan 11;23(1):18
pubmed: 33430923
Autoimmun Rev. 2015 Mar;14(3):201-3
pubmed: 25448042
Ann Rheum Dis. 2020 Jun;79(6):727-733
pubmed: 32332073
Ann Rheum Dis. 2016 Sep;75(9):1687-92
pubmed: 26443607
Nat Med. 2009 Jun;15(6):623-5
pubmed: 19448636
Rheumatology (Oxford). 2020 Jan 1;59(1):77-83
pubmed: 31834404
PLoS One. 2011 Mar 17;6(3):e17972
pubmed: 21437233
Rheumatology (Oxford). 2017 Jun 1;56(6):965-972
pubmed: 28339745
Clin Exp Rheumatol. 2010 Jan-Feb;28(1 Suppl 57):51-5
pubmed: 20412703
Appl Environ Microbiol. 2003 Jan;69(1):18-23
pubmed: 12513972