Does etiology really matter for epilepsy surgery outcome?
cognitive outcomes
epilepsy surgery
histopathology
prognosis
seizure outcomes
Journal
Brain pathology (Zurich, Switzerland)
ISSN: 1750-3639
Titre abrégé: Brain Pathol
Pays: Switzerland
ID NLM: 9216781
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
21
03
2021
accepted:
01
04
2021
entrez:
1
7
2021
pubmed:
2
7
2021
medline:
3
2
2022
Statut:
ppublish
Résumé
Multiple factors influence the outcomes of epilepsy surgery. Prognostic indicators varying from clinical characteristics, imaging findings, ictal, and interictal electrophysiological activity have been linked to surgical outcomes. In this review, we focus on the relatively under-studied role of the underlying epilepsy histopathology in driving post-surgical outcomes, specifically focusing on the broad categories of seizure outcomes and cognitive outcomes. For each of these two outcomes of interest, we answer two questions: 1)- does etiology matter? and 2)- how could it matter? The goal is to review the existing literature on the relationship between etiology and surgical outcomes to provide the best possible judgment as to whether a causal relationship exists between histopathology and the ultimate surgical outcome as an initial step. Then, we delve into the possible mechanisms via which such relationships can be explained. We conclude with a call to action to the epilepsy surgery and histopathology research community to push the mechanistic understanding of the pathology-outcome interaction and identify actionable knowledge and biomarkers that could inform patient care in a timely fashion.
Identifiants
pubmed: 34196987
doi: 10.1111/bpa.12965
pmc: PMC8412085
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12965Subventions
Organisme : NINDS NIH HHS
ID : R01 NS097719
Pays : United States
Informations de copyright
© 2021 The Authors. Brain Pathology published by John Wiley & Sons Ltd on behalf of International Society of Neuropathology.
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