Hypothalamic functional MRI activity in the initiation phase of spontaneous and glyceryl trinitrate-induced migraine attacks.
attack onset
attack provocation
headache
neuroimaging
Journal
The European journal of neuroscience
ISSN: 1460-9568
Titre abrégé: Eur J Neurosci
Pays: France
ID NLM: 8918110
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
revised:
07
06
2021
received:
06
11
2020
accepted:
18
06
2021
pubmed:
2
7
2021
medline:
24
8
2021
entrez:
1
7
2021
Statut:
ppublish
Résumé
The hypothalamus has been suggested to be important in the initiation cascade of migraine attacks based on clinical and biochemical observations. Previous imaging studies could not disentangle the changes due to the attack and those due to the trigger compound. With a novel approach, we assessed hypothalamic neuronal activity in early premonitory phases of glyceryl-trinitrate (GTN)-induced and spontaneous migraine attacks. We measured the hypothalamic blood oxygen level-dependent (BOLD) response to oral glucose ingestion with 3T-functional magnetic resonance imaging (MRI) in 27 women, 16 with migraine without aura and 11 controls group matched for age and body mass index (BMI), on 1 day without prior GTN administration and on a second day after GTN administration (to coincide with the premonitory phase of an induced attack). Interestingly, subgroups of patients with and without GTN-triggered attacks could be compared. Additionally, five migraineurs were investigated in a spontaneous premonitory phase. Linear mixed models were used to study between- and within-group effects. Without prior GTN infusion, the BOLD response to glucose was similar in migraine participants and controls (P = .41). After prior GTN infusion, recovery occurred steeper and faster in migraineurs (versus Day 1; P < .0001) and in those who developed an attack versus those who did not (P < .0001). Prior GTN infusion did not alter the glucose-induced response in controls (versus baseline; P = .71). Just before spontaneous attacks, the BOLD-response recovery was also faster (P < .0001). In this study, we found new and direct evidence of altered hypothalamic neuronal function in the immediate preclinical phase of both GTN-provoked and spontaneous migraine attacks.
Identifiants
pubmed: 34197660
doi: 10.1111/ejn.15369
pmc: PMC8457240
doi:
Substances chimiques
Nitroglycerin
G59M7S0WS3
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5189-5202Informations de copyright
© 2021 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
Références
Am J Clin Nutr. 2018 Jan 1;107(1):20-25
pubmed: 29381802
Eur J Neurol. 2007 Sep;14(9):983-8
pubmed: 17718689
Cephalalgia. 2016 Sep;36(10):951-9
pubmed: 26643378
Eur J Neurol. 1994 Sep;1(1):73-80
pubmed: 24283432
Cephalalgia. 1989 Sep;9(3):187-93
pubmed: 2507160
Pain. 2003 Dec;106(3):461-470
pubmed: 14659530
Cephalalgia. 2005 Oct;25(10):811-6
pubmed: 16162258
J Neurol Neurosurg Psychiatry. 1984 May;47(5):437-42
pubmed: 6376712
Headache. 2005 Jul-Aug;45(7):904-10
pubmed: 15985108
Cephalalgia. 2001 Sep;21(7):781-5
pubmed: 11595013
Neurology. 2018 Jul 24;91(4):e374-e381
pubmed: 29950439
Cephalalgia. 2018 Jan;38(1):1-211
pubmed: 29368949
J Neurol Neurosurg Psychiatry. 2001 Dec;71(6):747-51
pubmed: 11723194
Brain. 2014 Jan;137(Pt 1):232-41
pubmed: 24277718
Lancet Neurol. 2002 Nov;1(7):437-44
pubmed: 12849366
Lancet. 1998 Apr 4;351(9108):1043-51
pubmed: 9546526
J Magn Reson Imaging. 2006 Oct;24(4):918-21
pubmed: 16958062
Cephalalgia. 2006 Sep;26(9):1051-60
pubmed: 16919055
Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):5951-5
pubmed: 1631079
Curr Opin Neurol. 2010 Jun;23(3):275-81
pubmed: 20164768
Cephalalgia. 2006 Oct;26(10):1209-13
pubmed: 16961788
Headache. 2007 Nov-Dec;47(10):1418-26
pubmed: 18052951
Cephalalgia. 1996 May;16(3):169-74
pubmed: 8734768
Nat Rev Neurosci. 2011 Sep 20;12(10):570-84
pubmed: 21931334
Heart Rhythm. 2008 Dec;5(12):1695-701
pubmed: 19084808
Diabetes. 1999 Sep;48(9):1801-6
pubmed: 10480611
Cephalalgia. 2011 Oct;31(13):1359-67
pubmed: 21914734
Expert Rev Neurother. 2008 Mar;8(3):409-16
pubmed: 18345971
Neuroimage. 2012 Aug 15;62(2):782-90
pubmed: 21979382
Neuroimage. 2005 Jan 15;24(2):363-8
pubmed: 15627579
Trends Endocrinol Metab. 2020 Feb;31(2):118-130
pubmed: 31690508
JAMA. 2013 Nov 27;310(20):2191-4
pubmed: 24141714
Cephalalgia. 2008 Jul;28(7):714-22
pubmed: 18479471
Neurol Sci. 2007 May;28 Suppl 2:S198-202
pubmed: 17508170
Trends Neurosci. 2002 Dec;25(12):621-5
pubmed: 12446129
Eur J Neurosci. 2021 Aug;54(3):5189-5202
pubmed: 34197660
Diabetes. 2007 Oct;56(10):2547-50
pubmed: 17670916
Physiol Rev. 2017 Apr;97(2):553-622
pubmed: 28179394
Pain. 2004 Aug;110(3):675-680
pubmed: 15288408
Headache. 2004 Oct;44(9):865-72
pubmed: 15447695
Diabetes. 2012 Dec;61(12):3255-9
pubmed: 22851576
J Neurol Sci. 1991 Nov;106(1):75-81
pubmed: 1779242
Brain. 2016 Jul;139(Pt 7):1987-93
pubmed: 27190019
J Neurol Neurosurg Psychiatry. 1987 Jul;50(7):927-8
pubmed: 3114432
Br Med J. 1980 Sep 6;281(6241):658-60
pubmed: 7437756
Cephalalgia. 2004;24 Suppl 1:9-160
pubmed: 14979299
Neurology. 2003 Mar 25;60(6):935-40
pubmed: 12654956
Cephalalgia. 2009 Nov;29(11):1197-201
pubmed: 19811504
Headache. 2003 Mar;43(3):282-92
pubmed: 12603650