Hyperlipidemia Influences the Accuracy of Glucometer-Measured Blood Glucose Concentrations in Genetically Diverse Mice.
Blood Glucose
Diabetes
Glucometer
Hyperlipidemia
Mice
Journal
The American journal of the medical sciences
ISSN: 1538-2990
Titre abrégé: Am J Med Sci
Pays: United States
ID NLM: 0370506
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
14
10
2020
revised:
30
04
2021
accepted:
25
06
2021
pubmed:
2
7
2021
medline:
21
10
2021
entrez:
1
7
2021
Statut:
ppublish
Résumé
Glucometers are widely used in animal research due to simplicity and ease of utilization, but their accuracy in blood glucose assessment for hyperlipidemic mice is unknown. Here, we compared blood glucose levels measured by a glucometer with plasma glucose levels measured by a standard enzymatic assay for 325 genetically diverse F2 mice derived from LP and BALB/c (BALB) Apoe On chow diet, lab-measured plasma glucose levels were 279.5 ± 42.6 mg/dl (mean ± SD), while blood glucose values measured by glucometer were 138.7 ± 16.6 mg/dl. The two measures had no correlation (R Our results indicate that hyperlipidemia affects the accuracy of glucometers in measuring blood glucose levels of mice.
Sections du résumé
BACKGROUND
Glucometers are widely used in animal research due to simplicity and ease of utilization, but their accuracy in blood glucose assessment for hyperlipidemic mice is unknown.
METHODS
Here, we compared blood glucose levels measured by a glucometer with plasma glucose levels measured by a standard enzymatic assay for 325 genetically diverse F2 mice derived from LP and BALB/c (BALB) Apoe
RESULTS
On chow diet, lab-measured plasma glucose levels were 279.5 ± 42.6 mg/dl (mean ± SD), while blood glucose values measured by glucometer were 138.7 ± 16.6 mg/dl. The two measures had no correlation (R
CONCLUSIONS
Our results indicate that hyperlipidemia affects the accuracy of glucometers in measuring blood glucose levels of mice.
Identifiants
pubmed: 34197739
pii: S0002-9629(21)00247-0
doi: 10.1016/j.amjms.2021.06.014
pmc: PMC8478864
mid: NIHMS1721432
pii:
doi:
Substances chimiques
Blood Glucose
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
297-302Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK097120
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK116768
Pays : United States
Organisme : NHLBI NIH HHS
ID : R21 HL112281
Pays : United States
Informations de copyright
Copyright © 2021 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest None.
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