GR-mediated anti-inflammation of α-boswellic acid: Insights from in vitro and in silico studies.
Anti-Inflammatory Agents
/ pharmacology
Cell Line, Tumor
Cell Nucleus
/ metabolism
Down-Regulation
/ drug effects
Humans
Interleukin-1beta
/ metabolism
Molecular Docking Simulation
Molecular Dynamics Simulation
Protein Transport
/ drug effects
Receptors, Glucocorticoid
/ metabolism
Transcortin
/ genetics
Triterpenes
/ metabolism
Anti-inflammation
Dissociative ligand
Glucocorticoid receptor (GR)
α-Boswellic acid (α-BA)
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
ISSN: 1873-6351
Titre abrégé: Food Chem Toxicol
Pays: England
ID NLM: 8207483
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
received:
25
04
2021
revised:
24
06
2021
accepted:
28
06
2021
pubmed:
2
7
2021
medline:
15
12
2021
entrez:
1
7
2021
Statut:
ppublish
Résumé
Although multiple bioactivities of α-boswellic acid have been reported, the molecular mechanism of its anti-inflammatory action is not yet clear. Hence, glucocorticoid receptor (GR)-mediated anti-inflammation of α-boswellic acid was investigated in this work. Fluorescence polarization assay suggested that α-boswellic acid bound to GR with IC
Identifiants
pubmed: 34197882
pii: S0278-6915(21)00412-9
doi: 10.1016/j.fct.2021.112379
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents
0
IL1B protein, human
0
Interleukin-1beta
0
Receptors, Glucocorticoid
0
Triterpenes
0
alpha-boswellic acid
0
Transcortin
9010-38-2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
112379Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.