Historical perspective and progress on protein ubiquitination at glutamatergic synapses.
Animals
Axon Guidance
/ physiology
Dendritic Spines
/ metabolism
Glutamic Acid
/ metabolism
Humans
Neurons
/ metabolism
Post-Synaptic Density
/ metabolism
Presynaptic Terminals
/ metabolism
Proteasome Endopeptidase Complex
/ metabolism
Protein Processing, Post-Translational
/ physiology
Receptors, Glutamate
/ metabolism
Synapses
/ metabolism
Ubiquitin
/ metabolism
Ubiquitination
/ physiology
AMPA
Axon
Brain
Glutamate
Kainate
NMDA
Postsynaptic
Proteasome
Synapse
Ubiquitin
mGluR
Journal
Neuropharmacology
ISSN: 1873-7064
Titre abrégé: Neuropharmacology
Pays: England
ID NLM: 0236217
Informations de publication
Date de publication:
15 09 2021
15 09 2021
Historique:
received:
18
02
2021
revised:
07
06
2021
accepted:
22
06
2021
pubmed:
2
7
2021
medline:
3
2
2022
entrez:
1
7
2021
Statut:
ppublish
Résumé
Transcription-translation coupling leads to the production of proteins that are key for controlling essential neuronal processes that include neuronal development and changes in synaptic strength. Although these events have been a prevailing theme in neuroscience, the regulation of proteins via posttranslational signaling pathways are equally relevant for these neuronal processes. Ubiquitin is one type of posttranslational modification that covalently attaches to its targets/substrates. Ubiquitination of proteins play a key role in multiple signaling pathways, the predominant being removal of its substrates by a large molecular machine called the proteasome. Here, I review 40 years of progress on ubiquitination in the nervous system at glutamatergic synapses focusing on axon pathfinding, synapse formation, presynaptic release, dendritic spine formation, and regulation of postsynaptic glutamate receptors. Finally, I elucidate emerging themes in ubiquitin biology that may challenge our current understanding of ubiquitin signaling in the nervous system.
Identifiants
pubmed: 34197891
pii: S0028-3908(21)00245-8
doi: 10.1016/j.neuropharm.2021.108690
pmc: PMC8831078
mid: NIHMS1723354
pii:
doi:
Substances chimiques
Receptors, Glutamate
0
Ubiquitin
0
Glutamic Acid
3KX376GY7L
Proteasome Endopeptidase Complex
EC 3.4.25.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
108690Subventions
Organisme : NINDS NIH HHS
ID : R21 NS116760
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
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