Protective Effect of Lusianthridin on Hemin-Induced Low-Density Lipoprotein Oxidation.
cholesteryl arachidinate
cholesteryl linoleate
foam cell formation
hemin
lusianthridin
oxidation of low-density lipoprotein
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
14 Jun 2021
14 Jun 2021
Historique:
received:
22
05
2021
revised:
06
06
2021
accepted:
09
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
3
7
2021
Statut:
epublish
Résumé
Oxidation of low-density lipoprotein (LDL) plays a crucial role in the pathogenesis of atherosclerosis. Hemin (iron (III)-protoporphyrin IX) is a degradation product of hemoglobin that can be found in thalassemia patients. Hemin is a strong oxidant that can cause LDL oxidation and contributes to atherosclerosis in thalassemia patients. Lusianthridin from
Identifiants
pubmed: 34198641
pii: ph14060567
doi: 10.3390/ph14060567
pmc: PMC8232130
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Chulalongkorn University
ID : GRU 6404733002-1
Organisme : Chulalongkorn University
ID : Fund of Faculty of Pharmaceutical Sciences
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