'Carbon-Monoxide-Releasing Molecule-2 (CORM-2)' Is a Misnomer: Ruthenium Toxicity, Not CO Release, Accounts for Its Antimicrobial Effects.

CORM-2 amino acid antimicrobial agent bacteria carbon monoxide glutathione metal ruthenium compound thiol

Journal

Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981

Informations de publication

Date de publication:
05 Jun 2021
Historique:
received: 22 04 2021
revised: 31 05 2021
accepted: 02 06 2021
entrez: 2 7 2021
pubmed: 3 7 2021
medline: 3 7 2021
Statut: epublish

Résumé

Carbon monoxide (CO)-releasing molecules (CORMs) are used to deliver CO, a biological 'gasotransmitter', in biological chemistry and biomedicine. CORMs kill bacteria in culture and in animal models, but are reportedly benign towards mammalian cells. CORM-2 (tricarbonyldichlororuthenium(II) dimer, Ru

Identifiants

pubmed: 34198746
pii: antiox10060915
doi: 10.3390/antiox10060915
pmc: PMC8227206
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/M0225791/1
Pays : United Kingdom

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Auteurs

Hannah M Southam (HM)

Department of Molecular Biology and Biotechnology, The University of Sheffield, Western Bank, Sheffield S10 2TN, UK.

Michael P Williamson (MP)

Department of Molecular Biology and Biotechnology, The University of Sheffield, Western Bank, Sheffield S10 2TN, UK.

Jonathan A Chapman (JA)

Department of Molecular Biology and Biotechnology, The University of Sheffield, Western Bank, Sheffield S10 2TN, UK.
Centre for Bacterial Cell Biology, Medical School, Newcastle University, Newcastle upon Tyne NE2 4AX, UK.

Rhiannon L Lyon (RL)

Department of Molecular Biology and Biotechnology, The University of Sheffield, Western Bank, Sheffield S10 2TN, UK.

Clare R Trevitt (CR)

Department of Molecular Biology and Biotechnology, The University of Sheffield, Western Bank, Sheffield S10 2TN, UK.

Peter J F Henderson (PJF)

School of Biomedical Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK.

Robert K Poole (RK)

Department of Molecular Biology and Biotechnology, The University of Sheffield, Western Bank, Sheffield S10 2TN, UK.

Classifications MeSH