Effects of Palm Stearin versus Butter in the Context of Low-Carbohydrate/High-Fat and High-Carbohydrate/Low-Fat Diets on Circulating Lipids in a Controlled Feeding Study in Healthy Humans.
Adult
Aged
Butter
Cholesterol
/ blood
Cross-Over Studies
Diet
/ adverse effects
Diet, Carbohydrate Loading
/ adverse effects
Diet, Carbohydrate-Restricted
/ adverse effects
Diet, Fat-Restricted
/ adverse effects
Diet, High-Fat
/ adverse effects
Dietary Carbohydrates
/ administration & dosage
Dietary Fats
/ administration & dosage
Female
Healthy Volunteers
Humans
Lipids
/ blood
Male
Middle Aged
Palm Oil
/ administration & dosage
Young Adult
butter
cholesterol
low-carbohydrate diet
palm oil
saturated fat
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
05 Jun 2021
05 Jun 2021
Historique:
received:
15
04
2021
revised:
31
05
2021
accepted:
02
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
28
7
2021
Statut:
epublish
Résumé
Foods rich in saturated fatty acids (SFAs) have been discouraged by virtue of their cholesterol-raising potential, but this effect is modulated by the food source and background level of carbohydrate. We aimed to compare the consumption of palm stearin (PS) versus butter on circulating cholesterol responses in the setting of both a low-carbohydrate/high-fat (LC/HF) and high-carbohydrate/low-fat (HC/LF) diet in healthy subjects. We also explored effects on plasma lipoprotein particle distribution and fatty acid composition. We performed a randomized, controlled-feeding, cross-over study that compared a PS- versus a Butter-based diet in a group of normocholesterolemic, non-obese adults. A controlled canola oil-based 'Run-In' diet preceded the experimental PS and Butter diets. All diets were eucaloric, provided for 3-weeks, and had the same macronutrient distribution but varied in primary fat source (40% of the total fat). The same Run-In and cross-over experiments were done in two separate groups who self-selected to either a LC/HF ( Compared to PS, Butter resulted in higher LDL-C in both the LC/HF (13.4%, These results demonstrate that Butter raises LDL-C relative to PS in healthy normocholesterolemic adults regardless of background variations in carbohydrate and fat, an effect primarily attributed to larger cholesterol-rich LDL particles.
Sections du résumé
BACKGROUND
BACKGROUND
Foods rich in saturated fatty acids (SFAs) have been discouraged by virtue of their cholesterol-raising potential, but this effect is modulated by the food source and background level of carbohydrate.
OBJECTIVE
OBJECTIVE
We aimed to compare the consumption of palm stearin (PS) versus butter on circulating cholesterol responses in the setting of both a low-carbohydrate/high-fat (LC/HF) and high-carbohydrate/low-fat (HC/LF) diet in healthy subjects. We also explored effects on plasma lipoprotein particle distribution and fatty acid composition.
METHODS
METHODS
We performed a randomized, controlled-feeding, cross-over study that compared a PS- versus a Butter-based diet in a group of normocholesterolemic, non-obese adults. A controlled canola oil-based 'Run-In' diet preceded the experimental PS and Butter diets. All diets were eucaloric, provided for 3-weeks, and had the same macronutrient distribution but varied in primary fat source (40% of the total fat). The same Run-In and cross-over experiments were done in two separate groups who self-selected to either a LC/HF (
RESULTS
RESULTS
Compared to PS, Butter resulted in higher LDL-C in both the LC/HF (13.4%,
CONCLUSIONS
CONCLUSIONS
These results demonstrate that Butter raises LDL-C relative to PS in healthy normocholesterolemic adults regardless of background variations in carbohydrate and fat, an effect primarily attributed to larger cholesterol-rich LDL particles.
Identifiants
pubmed: 34198888
pii: nu13061944
doi: 10.3390/nu13061944
pmc: PMC8226735
pii:
doi:
Substances chimiques
Dietary Carbohydrates
0
Dietary Fats
0
Lipids
0
Palm Oil
5QUO05548Z
Butter
8029-34-3
Cholesterol
97C5T2UQ7J
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Malaysian Palm Oil Board
ID : 60049325
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