Broad-Spectrum Anticancer Activity and Pharmacokinetic Properties of a Prenyloxy-Substituted Indeno[1,2-

CK2 inhibitor LC-MS anticancer indeno[1,2-b]indole pharmacokinetics

Journal

Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453

Informations de publication

Date de publication:
05 Jun 2021
Historique:
received: 29 04 2021
revised: 28 05 2021
accepted: 02 06 2021
entrez: 2 7 2021
pubmed: 3 7 2021
medline: 3 7 2021
Statut: epublish

Résumé

Protein kinase CK2 is involved in regulating cellular processes, such as cell cycle, proliferation, migration, and apoptosis, making it an attractive anticancer target. We previously described a prenyloxy-substituted indeno[1,2-

Identifiants

pubmed: 34198928
pii: ph14060542
doi: 10.3390/ph14060542
pmc: PMC8226678
pii:
doi:

Types de publication

Journal Article

Langues

eng

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Auteurs

Ehab El-Awaad (E)

Institut für Pharmazeutische und Medizinische Chemie, PharmaCampus, Westfälische Wilhelms-Universität Münster, Corrensstr. 48, 48149 Münster, Germany.
Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut 71515, Egypt.

Robin Birus (R)

Institut für Pharmazeutische und Medizinische Chemie, PharmaCampus, Westfälische Wilhelms-Universität Münster, Corrensstr. 48, 48149 Münster, Germany.

Christelle Marminon (C)

Small Molecules for Biological Targets Team, Centre de Recherche en Cancérologie de Lyon, Centre Léon Bérard, CNRS 5286, INSERM 1052, Université Claude Bernard Lyon 1, Univ Lyon, 69373 Lyon, France.

Zouhair Bouaziz (Z)

EA 4446 Bioactive Molecules and Medicinal Chemistry, Université Claude Bernard Lyon 1, Univ Lyon, 69373 Lyon, France.

Laurens Ballentin (L)

Institut für Pharmazeutische und Medizinische Chemie, PharmaCampus, Westfälische Wilhelms-Universität Münster, Corrensstr. 48, 48149 Münster, Germany.

Dagmar Aichele (D)

Institut für Pharmazeutische und Medizinische Chemie, PharmaCampus, Westfälische Wilhelms-Universität Münster, Corrensstr. 48, 48149 Münster, Germany.

Marc Le Borgne (M)

Small Molecules for Biological Targets Team, Centre de Recherche en Cancérologie de Lyon, Centre Léon Bérard, CNRS 5286, INSERM 1052, Université Claude Bernard Lyon 1, Univ Lyon, 69373 Lyon, France.

Joachim Jose (J)

Institut für Pharmazeutische und Medizinische Chemie, PharmaCampus, Westfälische Wilhelms-Universität Münster, Corrensstr. 48, 48149 Münster, Germany.

Classifications MeSH