Three Different Genetic Risk Scores Based on Fatty Liver Index, Magnetic Resonance Imaging and Lipidomic for a Nutrigenetic Personalized Management of NAFLD: The Fatty Liver in Obesity Study.
NAFLD
fatty liver index
genetic risk score
lipidomic
magnetic resonance imaging
Journal
Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402
Informations de publication
Date de publication:
13 Jun 2021
13 Jun 2021
Historique:
received:
29
04
2021
revised:
03
06
2021
accepted:
11
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
3
7
2021
Statut:
epublish
Résumé
Non-alcoholic fatty liver disease (NAFLD) affects 25% of the global population. The pathogenesis of NAFLD is complex; available data reveal that genetics and ascribed interactions with environmental factors may play an important role in the development of this morbid condition. The purpose of this investigation was to assess genetic and non-genetic determinants putatively involved in the onset and progression of NAFLD after a 6-month weight loss nutritional treatment. A group of 86 overweight/obese subjects with NAFLD from the Fatty Liver in Obesity (FLiO) study were enrolled and metabolically evaluated at baseline and after 6 months. A pre-designed panel of 95 genetic variants related to obesity and weight loss was applied and analyzed. Three genetic risk scores (GRS) concerning the improvement on hepatic health evaluated by minimally invasive methods such as the fatty liver index (FLI) (GRS
Identifiants
pubmed: 34199237
pii: diagnostics11061083
doi: 10.3390/diagnostics11061083
pmc: PMC8231822
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Health Department of the Government of Navarra
ID : 61/2015
Organisme : Fundació la Marató de TV3
ID : 201630.10
Organisme : Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición
ID : CB12/03/3002
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