Current Understandings of Core Pathways for the Activation of Mammalian Primordial Follicles.
PI3K/PTEN signaling
fertilization
granulosa cells
in vitro activation
oocyte
primordial follicles
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
13 06 2021
13 06 2021
Historique:
received:
10
04
2021
revised:
09
06
2021
accepted:
10
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
27
10
2021
Statut:
epublish
Résumé
The mammalian ovary has two main functions-producing mature oocytes for fertilization and secreting hormones for maintaining the ovarian endocrine functions. Both functions are vital for female reproduction. Primordial follicles are composed of flattened pre-granulosa cells and a primary oocyte, and activation of primordial follicles is the first step in follicular development and is the key factor in determining the reproductive capacity of females. The recent identification of the phosphatidylinositol 3 kinase (PI3K)/phosphatase and tensin homolog deleted on chromosome 10 (PTEN) signaling pathway as the key controller for follicular activation has made the study of primordial follicle activation a hot research topic in the field of reproduction. This review systematically summarizes the roles of the PI3K/PTEN signaling pathway in primordial follicle activation and discusses how the pathway interacts with various other molecular networks to control follicular activation. Studies on the activation of primordial follicles have led to the development of methods for the in vitro activation of primordial follicles as a treatment for infertility in women with premature ovarian insufficiency or poor ovarian response, and these are also discussed along with some practical applications of our current knowledge of follicular activation.
Identifiants
pubmed: 34199299
pii: cells10061491
doi: 10.3390/cells10061491
pmc: PMC8231864
pii:
doi:
Substances chimiques
PTEN Phosphohydrolase
EC 3.1.3.67
PTEN protein, human
EC 3.1.3.67
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Shenzhen Science and Technology Innovation Program
ID : RCBS20200714114941343
Organisme : Sanming Project of Medicine in Shenzhen
ID : SZSM201612083, W.S.B.Y.
Organisme : High Level-Hospital Program, Health Commission of Guangdong Province
ID : HKUSZH201902018, K.L.
Organisme : Shenzhen-Hong Kong Innovation Circle Type D
ID : K.L.
Organisme : Shenzhen Project KQTD20190929172749226
ID : K.L., W.S.B.Y., T.R.W
Organisme : Shanghai Municipal Health Commission
ID : 20184Y0200
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