What Is the Metabolic Amplification of Insulin Secretion and Is It (Still) Relevant?
cytosolic calcium concentration
glucose
insulin secretion
metabolic amplification
mitochondria
nutrient secretagogues
Journal
Metabolites
ISSN: 2218-1989
Titre abrégé: Metabolites
Pays: Switzerland
ID NLM: 101578790
Informations de publication
Date de publication:
02 Jun 2021
02 Jun 2021
Historique:
received:
07
05
2021
revised:
27
05
2021
accepted:
31
05
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
3
7
2021
Statut:
epublish
Résumé
The pancreatic beta-cell transduces the availability of nutrients into the secretion of insulin. While this process is extensively modified by hormones and neurotransmitters, it is the availability of nutrients, above all glucose, which sets the process of insulin synthesis and secretion in motion. The central role of the mitochondria in this process was identified decades ago, but how changes in mitochondrial activity are coupled to the exocytosis of insulin granules is still incompletely understood. The identification of ATP-sensitive K
Identifiants
pubmed: 34199454
pii: metabo11060355
doi: 10.3390/metabo11060355
pmc: PMC8229681
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : Ru 368/5-4
Organisme : Deutsche Diabetes Gesellschaft
ID : n/a
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