DNA Homeostasis and Senescence: Lessons from the Naked Mole Rat.
DNA damage
DNA repair
ageing
naked mole rat
neurodegeneration
oxidative stress
reactive oxygen species
senescence
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
02 Jun 2021
02 Jun 2021
Historique:
received:
07
05
2021
revised:
28
05
2021
accepted:
31
05
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
13
7
2021
Statut:
epublish
Résumé
As we age, our bodies accrue damage in the form of DNA mutations. These mutations lead to the generation of sub-optimal proteins, resulting in inadequate cellular homeostasis and senescence. The build-up of senescent cells negatively affects the local cellular micro-environment and drives ageing associated disease, including neurodegeneration. Therefore, limiting the accumulation of DNA damage is essential for healthy neuronal populations. The naked mole rats (NMR) are from eastern Africa and can live for over three decades in chronically hypoxic environments. Despite their long lifespan, NMRs show little to no biological decline, neurodegeneration, or senescence. Here, we discuss molecular pathways and adaptations that NMRs employ to maintain genome integrity and combat the physiological and pathological decline in organismal function.
Identifiants
pubmed: 34199458
pii: ijms22116011
doi: 10.3390/ijms22116011
pmc: PMC8199619
pii:
doi:
Substances chimiques
DNA
9007-49-2
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Wellcome Trust
ID : 103844
Pays : United Kingdom
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