Diving into the Pleural Fluid: Liquid Biopsy for Metastatic Malignant Pleural Effusions.
cytomics
genomics
liquid biopsy
malignant pleural effusion
pleural fluid
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
04 Jun 2021
04 Jun 2021
Historique:
received:
26
04
2021
revised:
03
06
2021
accepted:
03
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
3
7
2021
Statut:
epublish
Résumé
Liquid biopsy is emerging as a promising non-invasive diagnostic tool for malignant pleural effusions (MPE) due to the low sensitivity of conventional pleural fluid (PF) cytological examination and the difficulty to obtain tissue biopsies, which are invasive and require procedural skills. Currently, liquid biopsy is increasingly being used for the detection of driver mutations in circulating tumor DNA (ctDNA) from plasma specimens to guide therapeutic interventions. Notably, malignant PF are richer than plasma in tumor-derived products with potential clinical usefulness, such as ctDNA, micro RNAs (miRNAs) and long non-coding RNAs (lncRNAs), and circulating tumor cells (CTC). Tumor-educated cell types, such as platelets and macrophages, have also been added to this diagnostic armamentarium. Herein, we will present an overview of the role of the preceding biomarkers, collectively known as liquid biopsy, in PF samples, as well as the main technical approaches used for their detection and quantitation, including a proper sample processing. Technical limitations of current platforms and future perspectives in the field will also be addressed. Using PF as liquid biopsy shows promise for use in current practice to facilitate the diagnosis and management of metastatic MPE.
Identifiants
pubmed: 34199799
pii: cancers13112798
doi: 10.3390/cancers13112798
pmc: PMC8200094
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Instituto de Salud Carlos III
ID : PI20-01500
Organisme : Sociedad Española de Neumología y Cirugía Torácica
ID : 678-2018
Organisme : Agència de Gestió d'Ajuts Universitaris i de Recerca
ID : 2017SRG1620
Organisme : Instituto de Salud Carlos III
ID : CP20/00039
Références
Curr Opin Pulm Med. 2019 Jul;25(4):362-368
pubmed: 31082996
Cancer Res. 2020 Apr 1;80(7):1371-1373
pubmed: 32075797
Clin Lung Cancer. 2006 Sep;8(2):140-5
pubmed: 17026816
PLoS One. 2021 Mar 26;16(3):e0248775
pubmed: 33770081
Nat Cell Biol. 2008 Dec;10(12):1470-6
pubmed: 19011622
Clin Cancer Res. 2013 Feb 1;19(3):691-8
pubmed: 23243218
JAMA Oncol. 2018 Jun 1;4(6):773-774
pubmed: 29242914
Oncol Lett. 2020 May;19(5):3495-3505
pubmed: 32269623
EMBO Mol Med. 2011 Aug;3(8):495-503
pubmed: 21744498
Proteomics. 2013 Jul;13(14):2125-34
pubmed: 23585444
Med Res Rev. 2012 Mar;32(2):326-48
pubmed: 22383180
Hereditas. 2020 Feb 26;157(1):6
pubmed: 32102688
Lancet. 2002 Jul 27;360(9329):295-305
pubmed: 12147373
Br J Cancer. 2006 Nov 20;95(10):1390-5
pubmed: 17060940
Pleura Peritoneum. 2016 Mar 1;1(1):45-56
pubmed: 30911607
Clin Biochem. 2015 Oct;48(15):1003-5
pubmed: 26234638
Transl Lung Cancer Res. 2019 Aug;8(4):392-400
pubmed: 31555514
Lab Invest. 2011 Apr;91(4):579-87
pubmed: 21116241
Clin Breast Cancer. 2007 Feb;7(6):471-9
pubmed: 17386124
Nat Rev Cancer. 2011 Jun;11(6):426-37
pubmed: 21562580
Ann Am Thorac Soc. 2013 Dec;10(6):582-9
pubmed: 24236662
Carcinogenesis. 2014 Sep;35(9):2113-20
pubmed: 24925027
Cancer Res. 1975 Mar;35(3):512-6
pubmed: 1090362
J Cancer Res Clin Oncol. 2010 Sep;136(9):1341-7
pubmed: 20155428
Cancer Res Treat. 2014 Apr;46(2):178-85
pubmed: 24851110
Cancer Res Treat. 2018 Jul;50(3):908-916
pubmed: 28934846
Clin Chem Lab Med. 2017 Oct 26;55(12):1962-1969
pubmed: 28306520
J Thorac Oncol. 2014 Feb;9(2):154-62
pubmed: 24419411
Cell. 2005 Aug 12;122(3):379-91
pubmed: 16096058
Nat Rev Clin Oncol. 2013 Aug;10(8):472-84
pubmed: 23836314
Expert Rev Mol Diagn. 2016 Dec;16(12):1283-1290
pubmed: 27796148
Oncotarget. 2015 Sep 29;6(29):27049-64
pubmed: 26267323
BMC Cancer. 2012 Sep 25;12:428
pubmed: 23009708
Arch Bronconeumol. 2014 May;50(5):161-5
pubmed: 24360987
Int J Clin Exp Pathol. 2014 Dec 01;7(12):8813-22
pubmed: 25674250
Mol Cancer Ther. 2017 May;16(5):948-955
pubmed: 28468865
Cancer Res. 1977 Mar;37(3):646-50
pubmed: 837366
Cancer Cytopathol. 2020 Jan;128(1):43-56
pubmed: 31751001
Int J Clin Exp Pathol. 2018 Jul 01;11(7):3647-3655
pubmed: 31949745
Nat Rev Genet. 2019 Feb;20(2):71-88
pubmed: 30410101
Thorac Cancer. 2019 Dec;10(12):2218-2224
pubmed: 31602787
Sci China Life Sci. 2021 Jan;64(1):22-50
pubmed: 32930921
Contemp Oncol (Pozn). 2019;23(3):133-140
pubmed: 31798327
Ann Am Thorac Soc. 2017 Jul;14(7):1169-1176
pubmed: 28557526
Br J Haematol. 1994 Apr;86(4):774-9
pubmed: 7918071
Sci Adv. 2019 Jun 19;5(6):eaav4275
pubmed: 31223646
N Engl J Med. 2018 Jan 11;378(2):113-125
pubmed: 29151359
RNA Biol. 2018 Feb 1;15(2):242-250
pubmed: 29219730
Cancer Res. 2013 Feb 1;73(3):1180-9
pubmed: 23243023
Sci Rep. 2020 Dec 10;10(1):21674
pubmed: 33303880
Cell. 2006 Jan 27;124(2):263-6
pubmed: 16439202
Clin Chem. 2003 May;49(5):740-5
pubmed: 12709364
N Engl J Med. 2002 Jun 20;346(25):1971-7
pubmed: 12075059
Rev Clin Esp (Barc). 2017 Apr;217(3):144-148
pubmed: 28038770
Tumour Biol. 2016 Oct 14;:
pubmed: 27743380
Nat Rev Cancer. 2019 Oct;19(10):553-567
pubmed: 31455893
Int J Oncol. 2016 Jun;48(6):2567-79
pubmed: 27035745
Nat Rev Drug Discov. 2021 Jan;20(1):6-7
pubmed: 33311580
Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):3514-9
pubmed: 24550495
N Engl J Med. 2020 Jan 2;382(1):41-50
pubmed: 31751012
Cell Physiol Biochem. 2018;49(2):816-827
pubmed: 30165346
J Clin Oncol. 2014 Nov 10;32(32):3673-9
pubmed: 25311215
Clin Chim Acta. 2017 Aug;471:177-184
pubmed: 28602964
J Thorac Oncol. 2012 Feb;7(2):355-64
pubmed: 22157369
BMC Cancer. 2018 Dec 10;18(1):1236
pubmed: 30526536
Clin Transl Sci. 2010 Oct;3(5):227-32
pubmed: 21500395
Front Mol Biosci. 2020 Jun 30;7:113
pubmed: 32695793
Oncol Lett. 2014 Oct;8(4):1889-1895
pubmed: 25202432
Br J Cancer. 2013 Oct 1;109(7):1821-8
pubmed: 24002608
Expert Rev Mol Diagn. 2018 Jan;18(1):7-17
pubmed: 29115895
Sci Rep. 2017 Aug 29;7(1):9789
pubmed: 28852197
Nat Med. 2014 May;20(5):548-54
pubmed: 24705333
Rev Mal Respir. 2007 Sep;24(7):859-67
pubmed: 17925668
Ann Oncol. 2015 Sep;26(9):1883-1889
pubmed: 26105600
Molecules. 2014 Feb 17;19(2):2077-88
pubmed: 24549232
Lung Cancer. 2008 May;60(2):175-82
pubmed: 18061305
Sci Transl Med. 2014 Feb 19;6(224):224ra24
pubmed: 24553385
Clin Cancer Res. 2007 Dec 1;13(23):7053-8
pubmed: 18056182
Cancer Epidemiol Biomarkers Prev. 1994 Jan-Feb;3(1):67-71
pubmed: 8118388
Mol Oncol. 2020 Feb;14(2):462-483
pubmed: 31785055
Onco Targets Ther. 2018 Apr 24;11:2333-2344
pubmed: 29731641
Eur Respir J. 2008 Oct;32(4):924-30
pubmed: 18508816
Nihon Eiseigaku Zasshi. 2011 May;66(3):553-7
pubmed: 21701086
Cell Oncol (Dordr). 2017 Oct;40(5):511-519
pubmed: 28577209
Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3713-8
pubmed: 21300873
Lung Cancer. 2005 Sep;49(3):413-5
pubmed: 15913841
Int J Oncol. 2018 Jun;52(6):2110-2118
pubmed: 29620164
Cancers (Basel). 2020 Sep 29;12(10):
pubmed: 33003583
Ann Oncol. 2018 Jan 1;29(1):200-208
pubmed: 29186353
Eur J Immunol. 2013 Jul;43(7):1933-9
pubmed: 23589311
Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):9704-9
pubmed: 26195750
Oncol Rep. 2017 Dec;38(6):3538-3544
pubmed: 29039588
Lung Cancer. 2013 Aug;81(2):207-12
pubmed: 23726527
Ann Transl Med. 2021 Jan;9(2):140
pubmed: 33569442
Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2544-2549
pubmed: 28223509
Cancer Cell. 2016 Dec 12;30(6):836-848
pubmed: 27960084
Int J Med Sci. 2021 Jan 30;18(6):1510-1518
pubmed: 33628109
N Engl J Med. 2017 Feb 16;376(7):629-640
pubmed: 27959700
J Clin Oncol. 2008 Jul 1;26(19):3213-21
pubmed: 18591556
Micromachines (Basel). 2018 Jul 04;9(7):
pubmed: 30424273
J Clin Oncol. 2011 Apr 20;29(12):1556-63
pubmed: 21422424
Eur Respir Rev. 2016 Jun;25(140):189-98
pubmed: 27246596
Clin Lung Cancer. 2011 Nov;12(6):380-6
pubmed: 21729655
J Cell Biol. 2011 Feb 7;192(3):373-82
pubmed: 21300848
Blood. 2009 Mar 19;113(12):2835-42
pubmed: 19036702
Am Fam Physician. 2006 Apr 1;73(7):1211-20
pubmed: 16623208
Nat Commun. 2011 Feb 01;2:180
pubmed: 21285958
Anticancer Res. 2018 Dec;38(12):6707-6714
pubmed: 30504380
Clin Chest Med. 1985 Mar;6(1):49-54
pubmed: 3847301
Cancer Cell. 2015 Nov 9;28(5):666-676
pubmed: 26525104
Diagnostics (Basel). 2018 Apr 18;8(2):
pubmed: 29670052
Dis Mon. 2013 Feb;59(2):29-57
pubmed: 23374395
PLoS One. 2012;7(8):e43268
pubmed: 22937028
Lung Cancer. 2015 May;88(2):208-14
pubmed: 25773866
Lung Cancer. 2018 Oct;124:45-52
pubmed: 30268479
Cell Adh Migr. 2016 Jul 3;10(4):360-7
pubmed: 26919626
Nature. 2017 Apr 26;545(7655):446-451
pubmed: 28445469
Am J Respir Cell Mol Biol. 2004 Jul;31(1):114-21
pubmed: 14975938
Adv Sci (Weinh). 2020 Jan 16;7(4):1902760
pubmed: 32099764
Lancet Oncol. 2014 Apr;15(4):406-14
pubmed: 24636208
Nat Rev Cancer. 2017 Apr;17(4):223-238
pubmed: 28233803
Int J Cancer. 2013 Aug 1;133(3):645-52
pubmed: 23354517
J Thorac Dis. 2018 May;10(5):2631-2637
pubmed: 29997924
Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10513-8
pubmed: 18663219
Sci Rep. 2019 Oct 21;9(1):15057
pubmed: 31636323
Nat Biotechnol. 2016 May;34(5):547-555
pubmed: 27018799
Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4589-94
pubmed: 9539782
Anticancer Res. 2010 Sep;30(9):3747-57
pubmed: 20944164
Cancer Med. 2020 Apr;9(8):2879-2890
pubmed: 32091667
J Transl Med. 2011 May 19;9:70
pubmed: 21595914
Oncoscience. 2015 Jul 31;2(7):629-34
pubmed: 26328272
J Thorac Oncol. 2014 Jul;9(7):1048-1052
pubmed: 24926551