Exploring the Physiological Role of Transthyretin in Glucose Metabolism in the Liver.
glucose metabolism
glucose transporters
liver
mitochondria
transthyretin
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
04 Jun 2021
04 Jun 2021
Historique:
received:
04
05
2021
revised:
26
05
2021
accepted:
01
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
27
7
2021
Statut:
epublish
Résumé
Transthyretin (TTR), a 55 kDa evolutionarily conserved protein, presents altered levels in several conditions, including malnutrition, inflammation, diabetes, and Alzheimer's Disease. It has been shown that TTR is involved in several functions, such as insulin release from pancreatic β-cells, recovery of blood glucose and glucagon levels of the islets of Langerhans, food intake, and body weight. Here, the role of TTR in hepatic glucose metabolism was explored by studying the levels of glucose in mice with different TTR genetic backgrounds, namely with two copies of the
Identifiants
pubmed: 34199897
pii: ijms22116073
doi: 10.3390/ijms22116073
pmc: PMC8200108
pii:
doi:
Substances chimiques
Glucose Transporter Type 3
0
Glucose Transporter Type 4
0
Prealbumin
0
Slc2a3 protein, mouse
0
Slc2a4 protein, mouse
0
Ttr protein, mouse
0
Pkm protein, mouse
EC 2.7.1.40
Pyruvate Kinase
EC 2.7.1.40
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Norte 2020
ID : Norte-01-0145-FEDER-000008-Porto Neurosciences and Neurologic Disease Research Initiative at I3S
Organisme : Fundação Millennium bcp
ID : N/A
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