The NHance

18F-FDG-PET/CT MET antibody cancer

Journal

Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304

Informations de publication

Date de publication:
10 Jun 2021
Historique:
received: 06 04 2021
revised: 27 05 2021
accepted: 08 06 2021
entrez: 2 7 2021
pubmed: 3 7 2021
medline: 3 7 2021
Statut: epublish

Résumé

Dysregulation of MET signaling has been implicated in tumorigenesis and metastasis. ARGX-111 combines complete blockade of this pathway with enhanced tumor cell killing and was investigated in 24 patients with MET-positive advanced cancers in a phase 1b study at four dose levels (0.3-10 mg/kg). ARGX-111 was well tolerated up to 3 mg/kg (MTD). Anti-tumor activity was observed in nearly half of the patients (46%) with a mean duration of treatment of 12 weeks. NHance

Identifiants

pubmed: 34200749
pii: biomedicines9060665
doi: 10.3390/biomedicines9060665
pmc: PMC8229762
pii:
doi:

Types de publication

Journal Article

Langues

eng

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Auteurs

Philippe Aftimos (P)

Medical Oncology Clinic, Institut Jules Bordet, Université Libre de Bruxelles, 1000 Brussels, Belgium.

Christian Rolfo (C)

University Hospital Antwerp, 2650 Edegem, Belgium.

Sylvie Rottey (S)

University Hospital Ghent, 9000 Ghent, Belgium.

Philippe Barthélémy (P)

Medical Oncology Unit, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg, France.

Christophe Borg (C)

Medical Oncology Department, University Hospital of Besançon, CEDEX, 25000 Besançon, France.

Keunchil Park (K)

Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.

Do-Youn Oh (DY)

Seoul National University Hospital, Seoul 03080, Korea.

Sang-We Kim (SW)

Asan Medical Center, Department of Oncology, University of Ulsan College of Medicine, Seoul 05505, Korea.

Natalie De Jonge (N)

Argenx BV, Industriepark Zwijnaarde 7, 9052 Ghent, Belgium.

Valérie Hanssens (V)

Argenx BV, Industriepark Zwijnaarde 7, 9052 Ghent, Belgium.

Karen Zwanenpoel (K)

University Hospital Antwerp, 2650 Edegem, Belgium.

Carla Molthoff (C)

Department of Radiology & Nuclear Medicine, VU University Medical Center Amsterdam, 1012 Amsterdam, The Netherlands.

Daniëlle Vugts (D)

Department of Radiology & Nuclear Medicine, VU University Medical Center Amsterdam, 1012 Amsterdam, The Netherlands.

Torsten Dreier (T)

Argenx BV, Industriepark Zwijnaarde 7, 9052 Ghent, Belgium.
AgomAb Therapeutics NV, 9000 Ghent, Belgium.

Peter Verheesen (P)

Argenx BV, Industriepark Zwijnaarde 7, 9052 Ghent, Belgium.

Guus A M S van Dongen (GAMS)

Department of Radiology & Nuclear Medicine, VU University Medical Center Amsterdam, 1012 Amsterdam, The Netherlands.

Julie Jacobs (J)

Argenx BV, Industriepark Zwijnaarde 7, 9052 Ghent, Belgium.

Luc Van Rompaey (L)

Argenx BV, Industriepark Zwijnaarde 7, 9052 Ghent, Belgium.

Anna Hultberg (A)

Argenx BV, Industriepark Zwijnaarde 7, 9052 Ghent, Belgium.

Paolo Michieli (P)

AgomAb Therapeutics NV, 9000 Ghent, Belgium.
Department of Oncology, University of Torino Medical School, 10124 Turin, Italy.

Patrick Pauwels (P)

University Hospital Antwerp, 2650 Edegem, Belgium.

Samson Fung (S)

Argenx BV, Industriepark Zwijnaarde 7, 9052 Ghent, Belgium.

Alain Thibault (A)

Argenx BV, Industriepark Zwijnaarde 7, 9052 Ghent, Belgium.

Hans de Haard (H)

Argenx BV, Industriepark Zwijnaarde 7, 9052 Ghent, Belgium.

Nicolas Leupin (N)

Argenx BV, Industriepark Zwijnaarde 7, 9052 Ghent, Belgium.

Ahmad Awada (A)

Medical Oncology Clinic, Institut Jules Bordet, Université Libre de Bruxelles, 1000 Brussels, Belgium.

Classifications MeSH