High miR-30 Expression Associates with Improved Breast Cancer Patient Survival and Treatment Outcome.
HER-2
anthracycline
breast cancer
chemotherapy
doxorubicin
lapatinib
metastasis
miR-30
p53
survival
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
10 Jun 2021
10 Jun 2021
Historique:
received:
27
05
2021
accepted:
07
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
3
7
2021
Statut:
epublish
Résumé
Deregulated miRNA expression has been suggested in several stages of breast cancer pathogenesis. We have studied the miR-30 family, in particular miR-30d, in relation to breast cancer patient survival and treatment outcomes. With tumor specimens from 1238 breast cancer patients, we analyzed the association of miR-30d expression with tumor characteristics with the 5-year occurrence of breast cancer-specific death or distant metastasis (BDDM), and with 10-year breast cancer survival (BCS). We conducted a two-stage drug-screen to investigate the impact of miR-30 family members (miR-30a-30e) on sensitivity to doxorubicin and lapatinib in six breast cancer cell lines HCC1937, HCC1954, MDA-MB-361, MCF7, MDA-MB-436 and CAL-120, using drug sensitivity scores (DSS) to compare the miR-30 family mimics to their specific inhibitors. The study was complemented with Ingenuity Pathway Analysis (IPA) with the METABRIC data. We found that while high miR-30d expression is typical for aggressive tumors, it predicts better metastasis-free (
Identifiants
pubmed: 34200751
pii: cancers13122907
doi: 10.3390/cancers13122907
pmc: PMC8230388
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Helsingin ja Uudenmaan Sairaanhoitopiiri
ID : TYH2017234
Organisme : The Sigrid Juselius Foundation
ID : 2016
Organisme : The Finnish Cancer Society
ID : 70057
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