Antibacterial Activity of a Promising Antibacterial Agent: 22-(4-(2-(4-Nitrophenyl-piperazin-1-yl)-acetyl)-piperazin-1-yl)-22-deoxypleuromutilin.
Animals
Anti-Bacterial Agents
/ pharmacology
Cell Line
Diterpenes
/ pharmacology
Insecta
/ microbiology
Methicillin-Resistant Staphylococcus aureus
/ drug effects
Mice
Mice, Inbred ICR
Microbial Sensitivity Tests
/ methods
Nitrophenols
/ pharmacology
Piperazine
/ pharmacology
Polycyclic Compounds
/ pharmacology
Rats
Staphylococcal Infections
/ drug therapy
Pleuromutilins
LC-MS/MS
MRSA
antibacterial activity
pharmacokinetic
pleuromutilin derivative
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
08 Jun 2021
08 Jun 2021
Historique:
revised:
21
05
2021
accepted:
05
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
15
7
2021
Statut:
epublish
Résumé
A novel pleuromutilin derivative, 22-(4-(2-(4-nitrophenyl-piperazin-1-yl)-acetyl)-piperazin-1-yl)-22-deoxypleuromutilin (NPDM), was synthesized in our laboratory and proved excellent antibacterial activity against methicillin-resistant
Identifiants
pubmed: 34201372
pii: molecules26123502
doi: 10.3390/molecules26123502
pmc: PMC8227856
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Diterpenes
0
Nitrophenols
0
Polycyclic Compounds
0
Piperazine
1RTM4PAL0V
4-nitrophenyl
2395-99-5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Key Research and Development Program of China
ID : No. 2016YFD0501300
Organisme : Guangdong Natural Science Funds for Distinguished Young Scholar
ID : No. 2019B151502002
Organisme : National Natural Science Foundation of China
ID : No. 31672602
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