Eph Receptors and Ephrins in Retinal Diseases.
Eph
Eph receptors
age-related macular degeneration
choroidal neovascularization
diabetic retinopathy
ephrin
proliferative vitreoretinopathy
retina
retinopathy of prematurity
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
08 Jun 2021
08 Jun 2021
Historique:
received:
10
04
2021
revised:
06
06
2021
accepted:
07
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
27
7
2021
Statut:
epublish
Résumé
Retinal diseases are the leading cause of irreversible blindness. They affect people of all ages, from newborns in retinopathy of prematurity, through age-independent diabetic retinopathy and complications of retinal detachment, to age-related macular degeneration (AMD), which occurs mainly in the elderly. Generally speaking, the causes of all problems are disturbances in blood supply, hypoxia, the formation of abnormal blood vessels, and fibrosis. Although the detailed mechanisms underlying them are varied, the common point is the involvement of Eph receptors and ephrins in their pathogenesis. In our study, we briefly discussed the pathophysiology of the most common retinal diseases (diabetic retinopathy, retinopathy of prematurity, proliferative vitreoretinopathy, and choroidal neovascularization) and collected available research results on the role of Eph and ephrins. We also discussed the safety aspect of the use of drugs acting on Eph and ephrin for ophthalmic indications.
Identifiants
pubmed: 34201393
pii: ijms22126207
doi: 10.3390/ijms22126207
pmc: PMC8227845
pii:
doi:
Substances chimiques
Ephrins
0
Receptors, Eph Family
EC 2.7.10.1
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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