Epileptic Seizure Detection on an Ultra-Low-Power Embedded RISC-V Processor Using a Convolutional Neural Network.


Journal

Biosensors
ISSN: 2079-6374
Titre abrégé: Biosensors (Basel)
Pays: Switzerland
ID NLM: 101609191

Informations de publication

Date de publication:
23 Jun 2021
Historique:
received: 14 05 2021
revised: 13 06 2021
accepted: 18 06 2021
entrez: 2 7 2021
pubmed: 3 7 2021
medline: 22 7 2021
Statut: epublish

Résumé

The treatment of refractory epilepsy via closed-loop implantable devices that act on seizures either by drug release or electrostimulation is a highly attractive option. For such implantable medical devices, efficient and low energy consumption, small size, and efficient processing architectures are essential. To meet these requirements, epileptic seizure detection by analysis and classification of brain signals with a convolutional neural network (CNN) is an attractive approach. This work presents a CNN for epileptic seizure detection capable of running on an ultra-low-power microprocessor. The CNN is implemented and optimized in MATLAB. In addition, the CNN is also implemented on a GAP8 microprocessor with RISC-V architecture. The training, optimization, and evaluation of the proposed CNN are based on the CHB-MIT dataset. The CNN reaches a median sensitivity of 90% and a very high specificity over 99% corresponding to a median false positive rate of 6.8 s per hour. After implementation of the CNN on the microcontroller, a sensitivity of 85% is reached. The classification of 1 s of EEG data takes t=35 ms and consumes an average power of P≈140 μW. The proposed detector outperforms related approaches in terms of power consumption by a factor of 6. The universal applicability of the proposed CNN based detector is verified with recording of epileptic rats. This results enable the design of future medical devices for epilepsy treatment.

Identifiants

pubmed: 34201480
pii: bios11070203
doi: 10.3390/bios11070203
pmc: PMC8301882
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Références

Brain. 2017 Jun 1;140(6):1680-1691
pubmed: 28459961
IEEE Trans Biomed Circuits Syst. 2012 Oct;6(5):424-36
pubmed: 23853229
Pharmaceutics. 2020 Nov 24;12(12):
pubmed: 33255396
CNS Spectr. 2004 Feb;9(2):98-101, 106-9
pubmed: 14999166
Electroencephalogr Clin Neurophysiol. 1996 Sep;99(3):257-66
pubmed: 8862115
JAMA Neurol. 2018 Mar 1;75(3):279-286
pubmed: 29279892
Annu Int Conf IEEE Eng Med Biol Soc. 2019 Jul;2019:6876-6879
pubmed: 31947420
Epilepsy Behav. 2003 Jun;4(3):226-33
pubmed: 12791323
Lancet Neurol. 2019 Dec;18(12):1112-1122
pubmed: 31587955
Sci Rep. 2019 Oct 30;9(1):15649
pubmed: 31666621
IEEE Trans Neural Syst Rehabil Eng. 2019 Nov;27(11):2284-2293
pubmed: 31562096
Clin Neurophysiol. 2010 Nov;121(11):1832-43
pubmed: 20471311
IEEE Trans Biomed Circuits Syst. 2019 Oct;13(5):804-813
pubmed: 31331897
J Neural Eng. 2019 Aug 14;16(5):051001
pubmed: 31151119
Clin Neurophysiol. 2007 Nov;118(11):2332-43
pubmed: 17889601
Curr Opin Neurol. 2018 Apr;31(2):198-210
pubmed: 29493559
J Neural Eng. 2018 Oct;15(5):056013
pubmed: 29932424
Epilepsia. 2018 Jun;59 Suppl 1:14-22
pubmed: 29873826
Pharmacol Rev. 2020 Jul;72(3):606-638
pubmed: 32540959
Lancet Neurol. 2021 Feb;20(2):86-87
pubmed: 33341147

Auteurs

Andreas Bahr (A)

Sensor System Electronics, Institute of Electrical Engineering and Information Technology, Kiel University, 24143 Kiel, Germany.

Matthias Schneider (M)

Sensor System Electronics, Institute of Electrical Engineering and Information Technology, Kiel University, 24143 Kiel, Germany.

Maria Avitha Francis (MA)

Sensor System Electronics, Institute of Electrical Engineering and Information Technology, Kiel University, 24143 Kiel, Germany.

Hendrik M Lehmann (HM)

CMOS Design, Technical University Braunschweig, 38106 Braunschweig, Germany.

Igor Barg (I)

Multicomponent Materials, Institute for Material Science, Kiel University, 24143 Kiel, Germany.

Anna-Sophia Buschhoff (AS)

Institute of Physiology, Kiel University, 24118 Kiel, Germany.

Peer Wulff (P)

Institute of Physiology, Kiel University, 24118 Kiel, Germany.

Thomas Strunskus (T)

Multicomponent Materials, Institute for Material Science, Kiel University, 24143 Kiel, Germany.

Franz Faupel (F)

Multicomponent Materials, Institute for Material Science, Kiel University, 24143 Kiel, Germany.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female
Humans United States Aged Cross-Sectional Studies Medicare Part C
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH