Poly(l-Lactic Acid)-co-poly(Butylene Adipate) New Block Copolymers for the Preparation of Drug-Loaded Long Acting Injectable Microparticles.

aripiprazole block copolymers long acting injectables microparticles poly(butylene adipate) poly(l-lactic acid) sustained release

Journal

Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003

Informations de publication

Date de publication:
23 Jun 2021
Historique:
received: 19 05 2021
revised: 19 06 2021
accepted: 21 06 2021
entrez: 2 7 2021
pubmed: 3 7 2021
medline: 3 7 2021
Statut: epublish

Résumé

The present study evaluates the use of newly synthesized poly(l-lactic acid)-co-poly(butylene adipate) (PLA/PBAd) block copolymers as microcarriers for the preparation of aripiprazole (ARI)-loaded long acting injectable (LAI) formulations. The effect of various PLA to PBAd ratios (95/5, 90/10, 75/25 and 50/50

Identifiants

pubmed: 34201567
pii: pharmaceutics13070930
doi: 10.3390/pharmaceutics13070930
pmc: PMC8308927
pii:
doi:

Types de publication

Journal Article

Langues

eng

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Auteurs

Vasiliki Karava (V)

Department of Pharmacy, Section of Pharmaceutical Technology, Zografou Campus, National and Kapodistrian University of Athens, 15784 Athens, Greece.

Aggeliki Siamidi (A)

Department of Pharmacy, Section of Pharmaceutical Technology, Zografou Campus, National and Kapodistrian University of Athens, 15784 Athens, Greece.

Marilena Vlachou (M)

Department of Pharmacy, Section of Pharmaceutical Technology, Zografou Campus, National and Kapodistrian University of Athens, 15784 Athens, Greece.

Evi Christodoulou (E)

Department of Chemistry, Laboratory of Polymer Chemistry and Technology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.

Nikolaos D Bikiaris (ND)

Department of Chemistry, Laboratory of Polymer Chemistry and Technology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.

Alexandra Zamboulis (A)

Department of Chemistry, Laboratory of Polymer Chemistry and Technology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.

Margaritis Kostoglou (M)

Laboratory of Chemical and Environmental Technology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.

Eleni Gounari (E)

Biohellenika Biotechnology Company, Leoforos Georgikis Scholis 65, 57001 Thessaloniki, Greece.
Department of Biochemistry, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.

Panagiotis Barmpalexis (P)

Department of Pharmaceutical Technology, School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.

Classifications MeSH