Overexpression of miR-125b in Osteoblasts Improves Age-Related Changes in Bone Mass and Quality through Suppression of Osteoclast Formation.

Age Factors Animals Bone Development Bone Resorption / genetics Mice Mice, Inbred C57BL Mice, Transgenic MicroRNAs / genetics Osteoblasts / metabolism Osteoclasts / metabolism Osteogenesis
bone development and aging fracture healing matrix vesicles miR-125b

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
23 Jun 2021
Historique:
received: 26 04 2021
revised: 06 06 2021
accepted: 21 06 2021
entrez: 2 7 2021
pubmed: 3 7 2021
medline: 27 7 2021
Statut: epublish

Résumé

We recently reported an unexpected role of osteoblast-derived matrix vesicles in the delivery of microRNAs to bone matrix. Of such microRNAs, we found that miR-125b inhibited osteoclast formation by targeting

Identifiants

DOI: 10.3390/ijms22136745 PMID: 34201781 PMC: PMC8267655
pubmed: 34201781
pii: ijms22136745
doi: 10.3390/ijms22136745
pmc: PMC8267655
pii:
doi:

Substances chimiques

MicroRNAs 0
Mirn125 microRNA, mouse 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : MEXT KAKENHI
ID : JP16K11443

Références

J Biol Chem. 1994 Jan 14;269(2):1183-90
pubmed: 8288580
Z Rheumatol. 2000;59 Suppl 1:1-9
pubmed: 10769428
Histochem J. 1993 Jun;25(6):446-51
pubmed: 8360080
Calcif Tissue Int. 1985 May;37(3):287-92
pubmed: 3926278
Dis Model Mech. 2021 May 1;14(5):
pubmed: 33970241
Commun Biol. 2020 Jan 16;3(1):30
pubmed: 31949279
J Bone Miner Res. 2009 Feb;24(2):196-208
pubmed: 19016594
Sports Med. 2014 Jan;44(1):37-53
pubmed: 24092631
Front Endocrinol (Lausanne). 2018 Aug 03;9:402
pubmed: 30123182
Clin Orthop Relat Res. 2011 Aug;469(8):2128-38
pubmed: 21116752
J Cell Biol. 1969 Apr;41(1):59-72
pubmed: 5775794
PLoS One. 2014 Oct 14;9(10):e109597
pubmed: 25313900
J Bone Miner Res. 2000 Oct;15(10):1905-11
pubmed: 11028442
Nat Cell Biol. 2009 Mar;11(3):228-34
pubmed: 19255566
Mol Endocrinol. 1993 Mar;7(3):462-7
pubmed: 8483481
PLoS Biol. 2004 Nov;2(11):e363
pubmed: 15502875
Sci Rep. 2018 Feb 26;8(1):3609
pubmed: 29483516
Arq Bras Endocrinol Metabol. 2006 Aug;50(4):579-85
pubmed: 17117283
Nucleic Acids Res. 2019 Apr 23;47(7):3353-3364
pubmed: 30820533
J Orthop Trauma. 2009 May-Jun;23(5 Suppl):S31-8
pubmed: 19390374
Bone. 1997 Feb;20(2):127-32
pubmed: 9028536
Science. 2001 Oct 26;294(5543):853-8
pubmed: 11679670
Osteoporos Int. 2016 Mar;27(3):861-871
pubmed: 26419471
Bone. 2016 Jul;88:47-55
pubmed: 27080510
Orphanet J Rare Dis. 2009 Feb 20;4:5
pubmed: 19232111
Proc Natl Acad Sci U S A. 1970 Nov;67(3):1513-20
pubmed: 5274475
J Extracell Vesicles. 2016 Jul 19;5:31292
pubmed: 27440105
Genes Dev. 1997 Dec 15;11(24):3482-96
pubmed: 9407039
Nat Cell Biol. 2007 Jun;9(6):654-9
pubmed: 17486113
J Bone Miner Res. 2001 Feb;16(2):386-97
pubmed: 11204439
Annu Rev Biochem. 2010;79:351-79
pubmed: 20533884
Development. 2011 Aug;138(15):3247-59
pubmed: 21750035
J Bone Miner Res. 1999 Jun;14(6):969-79
pubmed: 10352106
Nat Commun. 2016 Mar 07;7:10872
pubmed: 26947250
J Histochem Cytochem. 1959 Jan;7(1):39-41
pubmed: 13664936
Bone. 2016 Jun;87:147-58
pubmed: 27072517
Bone. 2003 Sep;33(3):387-98
pubmed: 13678781
Biochim Biophys Acta. 2009 Dec;1790(12):1592-8
pubmed: 19786074
Genes Dev. 1999 Sep 15;13(18):2412-24
pubmed: 10500098
Leukemia. 2011 Dec;25(12):1849-56
pubmed: 21738213

Auteurs

Shota Ito (S)

Department of Calcified Tissue Biology, Hiroshima University Graduate School of Biomedical and Health Sciences, Minami-ku, Hiroshima 734-8553, Japan.
Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical and Health Sciences, Minami-ku, Hiroshima 734-8553, Japan.
ORCID: 0000-0002-1907-9324

Tomoko Minamizaki (T)

Department of Calcified Tissue Biology, Hiroshima University Graduate School of Biomedical and Health Sciences, Minami-ku, Hiroshima 734-8553, Japan.

Shohei Kohno (S)

Department of Calcified Tissue Biology, Hiroshima University Graduate School of Biomedical and Health Sciences, Minami-ku, Hiroshima 734-8553, Japan.

Yusuke Sotomaru (Y)

Natural Science Center for Basic Research and Development, Hiroshima University, Minami-ku, Hiroshima 734-8551, Japan.

Yoshiaki Kitaura (Y)

Department of Bioengineering, The University of Tokyo Graduate School of Medicine, Bunkyo-ku, Tokyo 113-0033, Japan.

Shinsuke Ohba (S)

Department of Sensory and Motor System Medicine, The University of Tokyo Graduate School of Medicine, Bunkyo-ku, Tokyo 113-0033, Japan.

Toshie Sugiyama (T)

Department of Animal Science, Niigata University Graduate School of Science and Technology, Nishi-ku, Niigata 950-2181, Japan.

Jane E Aubin (JE)

Department of Molecular Genetics, University of Toronto, 1 King's College Circle, Medical Sciences Building, Toronto, ON M5S 1A8, Canada.

Kotaro Tanimoto (K)

Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical and Health Sciences, Minami-ku, Hiroshima 734-8553, Japan.

Yuji Yoshiko (Y)

Department of Calcified Tissue Biology, Hiroshima University Graduate School of Biomedical and Health Sciences, Minami-ku, Hiroshima 734-8553, Japan.

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Classifications MeSH

questionsmedicales.fr › Environnement et santé publique › Santé publique › Facteurs épidémiologiques › Facteurs âges › Overexpression of miR-125b in Osteoblasts...
questionsmedicales.fr › Eucaryotes › Animaux › Overexpression of miR-125b in Osteoblasts...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Développement locomoteur › Biominéralisation › Développement osseux › Overexpression of miR-125b in Osteoblasts...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Résorption osseuse › Overexpression of miR-125b in Osteoblasts...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Overexpression of miR-125b in Osteoblasts...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Overexpression of miR-125b in Osteoblasts...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Overexpression of miR-125b in Osteoblasts...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › microARN › Overexpression of miR-125b in Osteoblasts...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Ostéoblastes › Overexpression of miR-125b in Osteoblasts...
questionsmedicales.fr › Cellules › Cellules myéloïdes › Ostéoclastes › Overexpression of miR-125b in Osteoblasts...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Développement locomoteur › Biominéralisation › Développement osseux › Ostéogenèse › Overexpression of miR-125b in Osteoblasts...