The C-Terminal Domain of LRRK2 with the G2019S Substitution Increases Mutant A53T α-Synuclein Toxicity in Dopaminergic Neurons In Vivo.
AAVs
Parkinson’s disease
cell-autonomous mechanisms
leucine-rich repeat kinase 2
α-synuclein
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
23 Jun 2021
23 Jun 2021
Historique:
received:
27
04
2021
revised:
10
06
2021
accepted:
18
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
27
7
2021
Statut:
epublish
Résumé
Alpha-synuclein (α-syn) and leucine-rich repeat kinase 2 (LRRK2) play crucial roles in Parkinson's disease (PD). They may functionally interact to induce the degeneration of dopaminergic (DA) neurons via mechanisms that are not yet fully understood. We previously showed that the C-terminal portion of LRRK2 (ΔLRRK2) with the G2019S mutation (ΔLRRK2
Identifiants
pubmed: 34201785
pii: ijms22136760
doi: 10.3390/ijms22136760
pmc: PMC8268201
pii:
doi:
Substances chimiques
Mutant Proteins
0
SNCA protein, human
0
alpha-Synuclein
0
LRRK2 protein, human
EC 2.7.11.1
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
EC 2.7.11.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Centre National de la Recherche Scientifique
ID : rolling grants
Organisme : Commissariat à l'Énergie Atomique et aux Énergies Alternatives
ID : rolling grants
Organisme : Fondation de France
ID : AAP 2010, Engt 00016819 and AAP 2014, Engt 2014-0052580
Organisme : Association France Parkinson
ID : PhD extention grant 2016 and 2019
Organisme : Agence Nationale de la Recherche
ID : NeurATRIS, "Investissement d'Avenir", ANR-11-INBS-0011
Références
Lancet. 2005 Jan 29-Feb 4;365(9457):415-6
pubmed: 15680457
Elife. 2017 Nov 10;6:
pubmed: 29125462
Lancet Neurol. 2009 Dec;8(12):1128-39
pubmed: 19909911
PLoS One. 2012;7(1):e30834
pubmed: 22303461
Hum Mol Genet. 2012 Jun 1;21(11):2420-31
pubmed: 22357653
Hum Mol Genet. 2012 Apr 15;21(8):1861-76
pubmed: 22246294
Neurobiol Dis. 2006 Aug;23(2):329-41
pubmed: 16750377
Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9289-94
pubmed: 24927544
Science. 1997 Jun 27;276(5321):2045-7
pubmed: 9197268
PLoS One. 2011 Apr 06;6(4):e18568
pubmed: 21494637
J Neurol. 2000 Apr;247 Suppl 2:II3-10
pubmed: 10991663
Mov Disord. 2014 Jul;29(8):1057-60
pubmed: 24903616
Hum Mol Genet. 2009 Apr 15;18(R1):R48-59
pubmed: 19297401
Sci Rep. 2016 Sep 23;6:33897
pubmed: 27658356
J Neurosci. 2016 Jul 13;36(28):7415-27
pubmed: 27413152
Science. 2003 Oct 31;302(5646):841
pubmed: 14593171
Eur J Neurosci. 2019 Feb;49(3):339-363
pubmed: 30269383
Neurobiol Aging. 2012 Aug;33(8):1845.e5-6
pubmed: 22365050
Hum Mol Genet. 2012 Feb 15;21(4):890-9
pubmed: 22080837
Adv Neurobiol. 2017;14:123-143
pubmed: 28353282
Neurobiol Dis. 2020 Feb;134:104614
pubmed: 31605779
Hum Gene Ther Methods. 2012 Feb;23(1):18-28
pubmed: 22428977
J Biol Chem. 2015 Aug 7;290(32):19433-44
pubmed: 26078453
Nat Rev Neurosci. 2009 Jul;10(7):519-29
pubmed: 19513088
Neurobiol Aging. 2015 Mar;36(3):1601.e7-16
pubmed: 25619660
Neurobiol Dis. 2019 Sep;129:67-78
pubmed: 31102768
Neurobiol Dis. 2010 Dec;40(3):503-17
pubmed: 20659558
Nat Genet. 1998 Feb;18(2):106-8
pubmed: 9462735
Lancet. 2004 Sep 25-Oct 1;364(9440):1167-9
pubmed: 15451224
Hum Mol Genet. 2013 Oct 1;22(19):3869-82
pubmed: 23720495
Cells. 2020 Nov 30;9(12):
pubmed: 33266247
PLoS One. 2013 Nov 27;8(11):e81426
pubmed: 24312298
Acta Neuropathol. 2019 Jun;137(6):961-980
pubmed: 30927072
Nat Neurosci. 2006 Oct;9(10):1231-3
pubmed: 16980962
Cell Tissue Res. 2018 Jul;373(1):61-77
pubmed: 29234887
Neuron. 2004 Nov 18;44(4):595-600
pubmed: 15541308
J Biol Chem. 2008 Jun 13;283(24):16906-14
pubmed: 18397888
Hum Mol Genet. 2014 Sep 1;23(17):4621-38
pubmed: 24740878
Biochim Biophys Acta. 2009 Jul;1792(7):625-33
pubmed: 18973807
Nat Med. 2010 Sep;16(9):998-1000
pubmed: 20729864
Elife. 2016 Jan 29;5:
pubmed: 26824392
Nat Rev Dis Primers. 2017 Mar 23;3:17013
pubmed: 28332488
J Neuroinflammation. 2014 Mar 21;11:52
pubmed: 24655756
Cell. 2020 Sep 17;182(6):1508-1518.e16
pubmed: 32783917
Neuron. 2004 Nov 18;44(4):601-7
pubmed: 15541309
J Neuropathol Exp Neurol. 2003 Jun;62(6):644-54
pubmed: 12834109
Brain. 2018 May 1;141(5):1434-1454
pubmed: 29534157
Hum Mol Genet. 2017 Jan 1;26(1):226-232
pubmed: 28011712
Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1499-504
pubmed: 18230735
Ann Neurol. 2004 Feb;55(2):164-73
pubmed: 14755719
Mol Ther. 2015 May;23(5):918-930
pubmed: 25619725
Acta Neurol Scand. 2018 Nov;138(5):425-431
pubmed: 29989150
Nat Genet. 2009 Dec;41(12):1303-7
pubmed: 19915576
BMC Neurosci. 2016 Feb 01;17:6
pubmed: 26831335
Hum Mol Genet. 2006 Jan 15;15(2):223-32
pubmed: 16321986
Exp Neurobiol. 2019 Apr;28(2):134-145
pubmed: 31138985
J Neurosci. 2014 Jan 8;34(2):418-33
pubmed: 24403142
JAMA Neurol. 2015 Jan;72(1):100-5
pubmed: 25401511
FEBS J. 2015 Aug;282(15):2806-26
pubmed: 25899482
Neuron. 2009 Dec 24;64(6):807-27
pubmed: 20064389
Biochem J. 2012 Feb 1;441(3):987-94
pubmed: 22047502
Hum Mol Genet. 2007 Jan 15;16(2):223-32
pubmed: 17200152
Lancet Neurol. 2008 Jul;7(7):583-90
pubmed: 18539534
Exp Neurol. 2017 Dec;298(Pt B):236-245
pubmed: 28764903
Nature. 2020 Dec;588(7837):344-349
pubmed: 32814344
Hum Mol Genet. 2015 Mar 15;24(6):1563-73
pubmed: 25398949
J Parkinsons Dis. 2019;9(1):17-29
pubmed: 30741691
PLoS One. 2016 Sep 13;11(9):e0162717
pubmed: 27622765
Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):1635-1640
pubmed: 29386392
Sci Transl Med. 2018 Jan 10;10(423):
pubmed: 29321258
Front Neurosci. 2020 Jun 17;14:577
pubmed: 32625052
Sci Transl Med. 2018 Jul 25;10(451):
pubmed: 30045977
Mov Disord. 2010 Dec 15;25(16):2717-23
pubmed: 20939082
eNeuro. 2017 Mar 17;4(2):
pubmed: 28321439
Sci Transl Med. 2012 Dec 12;4(164):164ra161
pubmed: 23241745