Rosin Derivatives as a Platform for the Antiviral Drug Design.
A549 Cells
Anti-Bacterial Agents
/ pharmacology
Antifungal Agents
/ pharmacology
Antiviral Agents
/ pharmacology
Bacillus subtilis
/ drug effects
Candida tropicalis
/ drug effects
Cell Survival
/ drug effects
Drug Design
Escherichia coli
/ drug effects
Humans
Influenza, Human
/ drug therapy
Orthomyxoviridae
/ drug effects
Resins, Plant
/ chemistry
Structure-Activity Relationship
DAA
MTT assay
PASS-online modeling
SWISS-ADME web server
antibacterial activity
antiviral activity
biological activity
cytotoxicity
fungicidal activity
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
23 Jun 2021
23 Jun 2021
Historique:
received:
31
05
2021
revised:
18
06
2021
accepted:
21
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
22
7
2021
Statut:
epublish
Résumé
The increased complexity due to the emergence and rapid spread of new viral infections prompts researchers to search for potential antiviral and protective agents for mucous membranes among various natural objects, for example, plant raw materials, their individual components, as well as the products of their chemical modification. Due to their structure, resin acids are valuable raw materials of natural origin to synthesize various bioactive substances. Therefore, the purpose of this study was to confirm the possibility of using resin acid derivatives for the drug design. As a result, we studied the cytotoxicity and biological activity of resin acid derivatives. It was shown that a slight decrease in the viral load in the supernatants was observed upon stimulation of cells (
Identifiants
pubmed: 34201875
pii: molecules26133836
doi: 10.3390/molecules26133836
pmc: PMC8270270
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Antifungal Agents
0
Antiviral Agents
0
Resins, Plant
0
rosin
88S87KL877
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Science and Higher Education of the Russian Federation
ID : 075-15-2020-934 dated 17.11.2020
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