Macrophages Compensate for Loss of Protein Tyrosine Phosphatase N

Animals Colitis / etiology Dendritic Cells / immunology Dextran Sulfate / adverse effects Disease Models, Animal Disease Susceptibility Intestinal Mucosa / immunology Macrophages / immunology Mice Mice, Transgenic Phosphorylation Protein Tyrosine Phosphatase, Non-Receptor Type 2 / deficiency STAT1 Transcription Factor / metabolism Severity of Illness Index Signal Transduction T-Lymphocyte Subsets / immunology
PTPN2 colitis dendritic cells inflammatory bowel disease

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
25 Jun 2021
Historique:
received: 18 05 2021
revised: 03 06 2021
accepted: 08 06 2021
entrez: 2 7 2021
pubmed: 3 7 2021
medline: 27 7 2021
Statut: epublish

Résumé

Protein tyrosine phosphatase nonreceptor type 2 (PTPN2) plays a critical role in the pathogenesis of inflammatory bowel diseases (IBD). Mice lacking PTPN2 in dendritic cells (DCs) develop skin and liver inflammation by the age of 22 weeks due to a generalized loss of tolerance leading to uncontrolled immune responses. The effect of DC-specific PTPN2 loss on intestinal health, however, is unknown. The aim of this study was to investigate the DC-specific role of PTPN2 in the intestine during colitis development. PTPN2

Identifiants

DOI: 10.3390/ijms22136820 PMID: 34201918 PMC: PMC8269284
pubmed: 34201918
pii: ijms22136820
doi: 10.3390/ijms22136820
pmc: PMC8269284
pii:
doi:

Substances chimiques

STAT1 Transcription Factor 0
Stat1 protein, mouse 0
Dextran Sulfate 9042-14-2
Protein Tyrosine Phosphatase, Non-Receptor Type 2 EC 3.1.3.48
Ptpn2 protein, mouse EC 3.1.3.48

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Stiftung Experimentelle Biomedizin
ID : n/a
Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
ID : 314730-146204, 314730_166381 320030_184753
Organisme : Novartis Foundation for Biomedical Research
ID : n/a
Organisme : the Holcim Foundation for the Advancement of Science
ID : n/a

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Auteurs

Larissa Hering (L)

Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland.

Egle Katkeviciute (E)

Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland.

Marlene Schwarzfischer (M)

Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland.

Anna Niechcial (A)

Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland.

Julianne B Riggs (JB)

Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland.

Marcin Wawrzyniak (M)

Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland.

Kirstin Atrott (K)

Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland.

Marnix van de Sande (M)

Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland.

Silvia Lang (S)

Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland.
ORCID: 0000-0002-1216-899X

Burkhard Becher (B)

Institute of Experimental Immunology, University of Zurich, 8091 Zurich, Switzerland.

Gerhard Rogler (G)

Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland.

Michael Scharl (M)

Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland.

Marianne R Spalinger (MR)

Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland.
ORCID: 0000-0003-4498-0058

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Macrophages Compensate for Loss of Protein...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies du côlon › Colite › Macrophages Compensate for Loss of Protein...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système phagocytaire mononucléé › Cellules dendritiques › Macrophages Compensate for Loss of Protein...
questionsmedicales.fr › Glucides › Polyosides › Glucanes › Dextrane › Sulfate dextran › Macrophages Compensate for Loss of Protein...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Macrophages Compensate for Loss of Protein...
questionsmedicales.fr › Phénomènes physiologiques › Constitution physique › Prédisposition aux maladies › Macrophages Compensate for Loss of Protein...
questionsmedicales.fr › Tissus › Membranes › Muqueuse › Muqueuse intestinale › Macrophages Compensate for Loss of Protein...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Macrophages Compensate for Loss of Protein...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Macrophages Compensate for Loss of Protein...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Macrophages Compensate for Loss of Protein...
questionsmedicales.fr › Métabolisme › Phosphorylation › Macrophages Compensate for Loss of Protein...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein Tyrosine Phosphatases › Protein Tyrosine Phosphatases, Non-Receptor › Protein Tyrosine Phosphatase, Non-Receptor Type 2 › Macrophages Compensate for Loss of Protein...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription STAT › Facteur de transcription STAT-1 › Macrophages Compensate for Loss of Protein...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Enquêtes et questionnaires › Enquêtes de santé › Indicateurs d'état de santé › Acuité des besoins du patient › Indice de gravité de la maladie › Macrophages Compensate for Loss of Protein...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Macrophages Compensate for Loss of Protein...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Macrophages Compensate for Loss of Protein...