Lumbar Interbody Fusion Conducted on a Porcine Model with a Bioresorbable Ceramic/Biopolymer Hybrid Implant Enriched with Hyperstable Fibroblast Growth Factor 2.

FGF2 animal model autograft biomechanics ceramic collagen histology lumbar spinal fusion micro-CT tissue engineering

Journal

Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304

Informations de publication

Date de publication:
25 Jun 2021
Historique:
received: 06 06 2021
revised: 18 06 2021
accepted: 22 06 2021
entrez: 2 7 2021
pubmed: 3 7 2021
medline: 3 7 2021
Statut: epublish

Résumé

Many growth factors have been studied as additives accelerating lumbar fusion rates in different animal models. However, their low hydrolytic and thermal stability both in vitro and in vivo limits their workability and use. In the proposed work, a stabilized vasculogenic and prohealing fibroblast growth factor-2 (FGF2-STAB

Identifiants

pubmed: 34202232
pii: biomedicines9070733
doi: 10.3390/biomedicines9070733
pmc: PMC8301420
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Ministerstvo Zdravotnictví Ceské Republiky
ID : 17-31276A

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Auteurs

Milan Krticka (M)

Trauma Surgery Department, Faculty of Medicine, Masaryk University and The University Hospital Brno, 625 00 Brno, Czech Republic.

Ladislav Planka (L)

Department of Paediatric Surgery, Orthopedics and Traumatology, Faculty of Medicine, Masaryk University and The University Hospital Brno, 662 63 Brno, Czech Republic.

Lucy Vojtova (L)

CEITEC-Central European Institute of Technology, Brno University of Technology, 612 00 Brno, Czech Republic.

Vladimir Nekuda (V)

Trauma Surgery Department, Faculty of Medicine, Masaryk University and The University Hospital Brno, 625 00 Brno, Czech Republic.

Premysl Stastny (P)

CEITEC-Central European Institute of Technology, Brno University of Technology, 612 00 Brno, Czech Republic.

Radek Sedlacek (R)

Department of Mechanics, Biomechanics and Mechatronics, Faculty of Mechanical Engineering, Czech Technical University in Prague, 160 00 Prague, Czech Republic.

Adam Brinek (A)

CEITEC-Central European Institute of Technology, Brno University of Technology, 612 00 Brno, Czech Republic.

Michaela Kavkova (M)

CEITEC-Central European Institute of Technology, Brno University of Technology, 612 00 Brno, Czech Republic.

Eduard Gopfert (E)

Veterinary Research Institute, 621 00 Brno, Czech Republic.

Vera Hedvicakova (V)

University Center for Energy Efficient Buildings, Czech Technical University in Prague, 273 43 Bustehrad, Czech Republic.
Department of Tissue Engineering, Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, 142 20 Prague, Czech Republic.

Michala Rampichova (M)

University Center for Energy Efficient Buildings, Czech Technical University in Prague, 273 43 Bustehrad, Czech Republic.
Department of Tissue Engineering, Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, 142 20 Prague, Czech Republic.

Leos Kren (L)

Department of Pathology, Faculty of Medicine of Masaryk University and The University Hospital Brno, 625 00 Brno, Czech Republic.

Kvetoslava Liskova (K)

Department of Pathology, Faculty of Medicine of Masaryk University and The University Hospital Brno, 625 00 Brno, Czech Republic.

Daniel Ira (D)

Trauma Surgery Department, Faculty of Medicine, Masaryk University and The University Hospital Brno, 625 00 Brno, Czech Republic.

Jana Dorazilová (J)

CEITEC-Central European Institute of Technology, Brno University of Technology, 612 00 Brno, Czech Republic.

Tomas Suchy (T)

Department of Composites and Carbon Materials, Institute of Rock Structure and Mechanics, The Czech Academy of Sciences, 182 09 Prague, Czech Republic.

Tomas Zikmund (T)

CEITEC-Central European Institute of Technology, Brno University of Technology, 612 00 Brno, Czech Republic.

Jozef Kaiser (J)

CEITEC-Central European Institute of Technology, Brno University of Technology, 612 00 Brno, Czech Republic.

David Stary (D)

Department of Paediatric Surgery, Orthopedics and Traumatology, Faculty of Medicine, Masaryk University and The University Hospital Brno, 662 63 Brno, Czech Republic.

Martin Faldyna (M)

Veterinary Research Institute, 621 00 Brno, Czech Republic.

Martin Trunec (M)

CEITEC-Central European Institute of Technology, Brno University of Technology, 612 00 Brno, Czech Republic.

Classifications MeSH