Perioperative GABA Blood Concentrations in Infants with Cyanotic and Non-Cyanotic Congenital Heart Diseases.

GABA brain cardiopulmonary by-pass children cooling newborn reoxygenation

Journal

Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402

Informations de publication

Date de publication:
24 Jun 2021
Historique:
received: 11 05 2021
revised: 21 06 2021
accepted: 23 06 2021
entrez: 2 7 2021
pubmed: 3 7 2021
medline: 3 7 2021
Statut: epublish

Résumé

Perioperative stress detection in children with congenital heart disease (CHD), particularly in the brain, is still limited. Among biomarkers, γ-amino-aminobutyric acid (GABA) assessment in biological fluids appears to be promising for its regulatory action on the cardiovascular and cerebral systems. We aimed to investigate cyanotic (C) or non-cyanotic (N) CHD children for GABA blood level changes in the perioperative period. We conducted an observational study in 68 CHD infants (C:

Identifiants

pubmed: 34202425
pii: diagnostics11071149
doi: 10.3390/diagnostics11071149
pmc: PMC8304774
pii:
doi:

Types de publication

Journal Article

Langues

eng

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Auteurs

Angela Satriano (A)

Department of Pediatric Cardiac Surgery IRCCS San Donato Milanese Hospital, 20097 San Donato Milanese, Italy.

Alessandro Varrica (A)

Department of Pediatric Cardiac Surgery IRCCS San Donato Milanese Hospital, 20097 San Donato Milanese, Italy.

Alessandro Frigiola (A)

Department of Pediatric Cardiac Surgery IRCCS San Donato Milanese Hospital, 20097 San Donato Milanese, Italy.

Alessandro Graziosi (A)

Neonatal Intensive Care Unit, Department of Pediatrics, University of Chieti, 65100 Chieti, Italy.

Caterina Di Battista (C)

Neonatal Intensive Care Unit, Department of Pediatrics, University of Chieti, 65100 Chieti, Italy.

Adele Patrizia Primavera (AP)

Neonatal Intensive Care Unit, Department of Pediatrics, University of Chieti, 65100 Chieti, Italy.

Giacomo Centini (G)

Department of Maternal Fetal and Neonatal Medicine, C. Arrigo Children's Hospital Alessandria, 15100 Alessandria, Italy.

Antonio Maconi (A)

Department of Maternal Fetal and Neonatal Medicine, C. Arrigo Children's Hospital Alessandria, 15100 Alessandria, Italy.

Chiara Strozzi (C)

Department of Maternal Fetal and Neonatal Medicine, C. Arrigo Children's Hospital Alessandria, 15100 Alessandria, Italy.

Antonio D W Gavilanes (ADW)

Department of Pediatrics, Neonatology and Child Neurology, Maastricht University, 6200 MD Maastricht, The Netherlands.

Luc J Zimmermann (LJ)

Department of Pediatrics, Neonatology and Child Neurology, Maastricht University, 6200 MD Maastricht, The Netherlands.

Hans J S Vles (HJS)

Department of Pediatrics, Neonatology and Child Neurology, Maastricht University, 6200 MD Maastricht, The Netherlands.

Diego Gazzolo (D)

Neonatal Intensive Care Unit, Department of Pediatrics, University of Chieti, 65100 Chieti, Italy.

Classifications MeSH