The Role of Cholesterol in Amyloidogenic Substrate Binding to the γ-Secretase Complex.
Alzheimer’s disease
amyloid precursor protein
cholesterol
membrane proteolysis
γ-secretase complex
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
24 06 2021
24 06 2021
Historique:
received:
03
05
2021
revised:
16
06
2021
accepted:
17
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
23
9
2021
Statut:
epublish
Résumé
Alzheimer's disease is the most common progressive neurodegenerative disorder and is characterized by the presence of amyloid β (Aβ) plaques in the brain. The γ-secretase complex, which produces Aβ, is an intramembrane-cleaving protease consisting of four membrane proteins. In this paper we investigated the amyloidogenic fragments of amyloid precursor protein (substrates Aβ
Identifiants
pubmed: 34202467
pii: biom11070935
doi: 10.3390/biom11070935
pmc: PMC8301813
pii:
doi:
Substances chimiques
Amyloid beta-Peptides
0
Peptide Fragments
0
amyloid beta-protein (1-43)
0
Cholesterol
97C5T2UQ7J
Amyloid Precursor Protein Secretases
EC 3.4.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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