Dissection of

PIK3CA cervical adenocarcinoma mutation

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
28 Jun 2021
Historique:
received: 06 04 2021
revised: 07 06 2021
accepted: 15 06 2021
entrez: 2 7 2021
pubmed: 3 7 2021
medline: 3 7 2021
Statut: epublish

Résumé

Personalized treatment of genetically stratified subgroups has the potential to improve outcomes in many malignant tumors. This study distills clinically meaningful prognostic/predictive genomic marker for cervical adenocarcinoma using signature genomic aberrations and single-point nonsynonymous mutation-specific droplet digital PCR (ddPCR). Mutations in

Identifiants

pubmed: 34203201
pii: cancers13133218
doi: 10.3390/cancers13133218
pmc: PMC8269188
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Hong Kong Research Grant Council
ID : 14101315

Références

Gynecol Oncol. 2013 Mar;128(3):409-14
pubmed: 23266353
Cancer. 2013 Nov 1;119(21):3776-83
pubmed: 24037752
Cell Cycle. 2009 May 1;8(9):1352-8
pubmed: 19305151
Am J Obstet Gynecol. 2017 Oct;217(4):432.e1-432.e17
pubmed: 28599900
J Natl Cancer Inst Monogr. 2003;(31):35-40
pubmed: 12807943
Nature. 2017 Mar 16;543(7645):378-384
pubmed: 28112728
Semin Cancer Biol. 2019 Dec;59:36-49
pubmed: 30742905
Sci Rep. 2015 Sep 11;5:14035
pubmed: 26358014
Oncotarget. 2015 Mar 10;6(7):4968-75
pubmed: 25669975
Exp Ther Med. 2019 Sep;18(3):2278-2284
pubmed: 31410178
EBioMedicine. 2019 May;43:253-260
pubmed: 30952619
Nature. 2014 Feb 20;506(7488):371-5
pubmed: 24390348
Technol Cancer Res Treat. 2020 Jan-Dec;19:1533033820921248
pubmed: 32329414
Int J Cancer. 2015 Aug 15;137(4):776-83
pubmed: 25626421
Medicine (Baltimore). 2018 Aug;97(31):e11392
pubmed: 30075505
Ann Oncol. 2019 Jun 1;30(6):945-952
pubmed: 30860573
Cancer. 2020 Jan 15;126(2):373-380
pubmed: 31769875
Mod Pathol. 2017 Nov;30(11):1633-1641
pubmed: 28731050

Auteurs

Tony K H Chung (TKH)

The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.

Graeme Doran (G)

Firefly Bioworks, Inc., Cambridge, MA 02139, USA.

Tak-Hong Cheung (TH)

The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.

So-Fan Yim (SF)

The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.

Mei-Yung Yu (MY)

The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.

Michael J Worley (MJ)

Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA.

Kevin M Elias (KM)

Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA.

Aaron R Thorner (AR)

Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

Chandra Sekhar Pedamallu (CS)

Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

Akinyemi I Ojesina (AI)

Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Kei-Man Lau (KM)

The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.

Matthew D Ducar (MD)

Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

Raymond R Y Wong (RRY)

The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.

Vivian W Wang (VW)

Mayo Clinic, Rochester, MN 55902, USA.

Anwesha Nag (A)

Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

Bruce M Wollison (BM)

Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

Audrey Dalgarno (A)

Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

Jacqueline H S Lee (JHS)

The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.

Suet-Ying Yeung (SY)

The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.

Lo Wong (L)

The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.

Neil S Horowitz (NS)

Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA.

Michelle R Davis (MR)

Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA.

Shuk-On A Leung (SA)

Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA.

Yi Mu (Y)

Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA.

Samuel C Mok (SC)

MD Anderson Cancer Center, The University of Texas, Houston, TX 77030, USA.

Paul K S Chan (PKS)

The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.

Michael S Lawrence (MS)

Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA.

Christopher P Crum (CP)

Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA.

Rossa W K Chiu (RWK)

The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.

Ross S Berkowitz (RS)

Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA.

Yick-Fu Wong (YF)

The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.
Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA.

Classifications MeSH