HCC in the Era of Direct-Acting Antiviral Agents (DAAs): Surgical and Other Curative or Palliative Strategies in the Elderly.

DAA HCC HCC recurrence HCV hepatitis C virus hepatocellular carcinoma locoregional therapy surgery

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
17 Jun 2021
Historique:
received: 29 04 2021
revised: 14 06 2021
accepted: 15 06 2021
entrez: 2 7 2021
pubmed: 3 7 2021
medline: 3 7 2021
Statut: epublish

Résumé

Hepatocellular carcinoma (HCC) accounts for 75-85% of primary liver malignancies, and elderlies have the highest incidence rates. Direct-acting antiviral agents (DAAs) have shown satisfying results in terms of HCV sustained viral response (SVR). However, data regarding HCC risk post-DAA-SVR is still conflicting. This study aims to consider HCC onset in moderate underlying liver disease. We conducted a retrospective study on 227 chronically infected patients (cHCV), treated with DAAs. Patients were divided into three groups: "

Identifiants

pubmed: 34204186
pii: cancers13123025
doi: 10.3390/cancers13123025
pmc: PMC8235445
pii:
doi:

Types de publication

Journal Article

Langues

eng

Références

Gastroenterology. 2009 Jan;136(1):138-48
pubmed: 18848939
Infect Dis Clin North Am. 2019 Dec;33(4):1045-1062
pubmed: 31668190
BMC Infect Dis. 2012 Dec 18;12:357
pubmed: 23245594
J Interferon Cytokine Res. 2020 Feb;40(2):82-91
pubmed: 31800346
Gastrointest Tumors. 2020 Apr;7(1-2):50-60
pubmed: 32399465
J Hepatol. 2016 Nov;65(5):1070-1071
pubmed: 27476768
J Hepatol. 2018 Jul;69(1):182-236
pubmed: 29628281
J Hepatocell Carcinoma. 2020 Apr 15;7:45-76
pubmed: 32346535
Int J Surg Case Rep. 2018;47:19-21
pubmed: 29704738
World J Hepatol. 2019 Jan 27;11(1):1-18
pubmed: 30705715
Expert Rev Anti Infect Ther. 2019 May;17(5):311-325
pubmed: 30856022
World J Gastroenterol. 2018 Jun 28;24(24):2582-2595
pubmed: 29962815
Liver Int. 2019 Jun;39(6):1033-1043
pubmed: 30636361
Lancet. 2019 Apr 6;393(10179):1453-1464
pubmed: 30765123
J Hepatol. 2018 Aug;69(2):461-511
pubmed: 29650333
Mod Pathol. 2010 Feb;23(2):276-83
pubmed: 19935643
Chin Clin Oncol. 2013 Dec;2(4):33
pubmed: 25841912
Semin Liver Dis. 1999;19(3):329-38
pubmed: 10518312
CA Cancer J Clin. 2021 May;71(3):209-249
pubmed: 33538338
Hepatology. 2007 Jul;46(1):32-6
pubmed: 17567829
Gastroenterology. 2019 Jan;156(2):477-491.e1
pubmed: 30367835
PLoS One. 2017 Jun 15;12(6):e0179096
pubmed: 28617830
Gastroenterology. 2017 Mar;152(4):911-912
pubmed: 28161225
Hepatol Res. 2020 May;50(5):535-541
pubmed: 32072721
Hepatology. 2017 Jul;66(1):167-181
pubmed: 28370287
J Hepatol. 2016 Oct;65(4):727-733
pubmed: 27349488
J Hepatol. 2018 Aug;69(2):345-352
pubmed: 29551707
Hepatol Res. 2019 May;49(5):570-578
pubmed: 30623521
Gastroenterology. 2019 Nov;157(5):1264-1278.e4
pubmed: 31356807
J Hepatol. 2010 May;52(5):652-7
pubmed: 20346533
J Hepatol. 2016 Oct;65(4):856-858
pubmed: 27318327
Clin Mol Hepatol. 2015 Jun;21(2):105-14
pubmed: 26157746
PLoS One. 2018 Apr 16;13(4):e0194704
pubmed: 29659591
N Engl J Med. 2011 Sep 22;365(12):1118-27
pubmed: 21992124
Clin Infect Dis. 2015 Oct 15;61(8):1304-6
pubmed: 26082511
Curr Opin Virol. 2016 Oct;20:1-10
pubmed: 27504999
J Clin Med. 2020 Nov 25;9(12):
pubmed: 33255794
Clin Gastroenterol Hepatol. 2016 Nov;14(11):1662-1666.e1
pubmed: 27211502
J Hepatol. 2016 Oct;65(4):719-726
pubmed: 27084592

Auteurs

Stefania Brozzetti (S)

Department of Surgery "Pietro Valdoni", Policlinico Umberto I, University of Rome La Sapienza, 00161 Rome, Italy.

Marsia Tancredi (M)

Department of Surgery "Pietro Valdoni", Policlinico Umberto I, University of Rome La Sapienza, 00161 Rome, Italy.

Simone Bini (S)

Department of Translational and Precision Medicine, Policlinico Umberto I, University of Rome La Sapienza, 00161 Rome, Italy.

Chiara De Lucia (C)

Department of Surgery "Pietro Valdoni", Policlinico Umberto I, University of Rome La Sapienza, 00161 Rome, Italy.

Jessica Antimi (J)

Department of Surgery "Pietro Valdoni", Policlinico Umberto I, University of Rome La Sapienza, 00161 Rome, Italy.

Chiara D'Alterio (C)

Department of Surgery "Pietro Valdoni", Policlinico Umberto I, University of Rome La Sapienza, 00161 Rome, Italy.

Giuseppe Maria De Sanctis (GM)

Department of Tropical and Infectious Diseases, Policlinico Umberto I, University of Rome La Sapienza, 00161 Rome, Italy.

Caterina Furlan (C)

Department of Tropical and Infectious Diseases, Policlinico Umberto I, University of Rome La Sapienza, 00161 Rome, Italy.

Vittoria Carolina Malpassuti (VC)

Department of Statistical Sciences, University of Rome La Sapienza, 00161 Rome, Italy.

Pierleone Lucatelli (P)

Department of Radiological Sciences Policlinico Umberto I, University of Rome La Sapienza, 00161 Rome, Italy.

Michele Di Martino (M)

Department of Radiological Sciences Policlinico Umberto I, University of Rome La Sapienza, 00161 Rome, Italy.

Mario Bezzi (M)

Department of Radiological Sciences Policlinico Umberto I, University of Rome La Sapienza, 00161 Rome, Italy.

Antonio Ciardi (A)

Department of Radiological, Oncological, Pathological Sciences, Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, Italy.

Rosa Maria Pascale (RM)

Department of Medical, Surgery and Experimental Sciences, Division of Experimental Pathology and Oncology, University of Sassari, 07100 Sassari, Italy.

Classifications MeSH