Potential and Limits of Cannabinoids in Alzheimer's Disease Therapy.
2-AG
Alzheimer’s disease
CB1
CB2
FAAH
THC
amyloid-β
anandamide
cannabidiol
cannabinoids
Journal
Biology
ISSN: 2079-7737
Titre abrégé: Biology (Basel)
Pays: Switzerland
ID NLM: 101587988
Informations de publication
Date de publication:
17 Jun 2021
17 Jun 2021
Historique:
received:
14
05
2021
revised:
13
06
2021
accepted:
14
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
3
7
2021
Statut:
epublish
Résumé
Alzheimer's disease (AD) is a detrimental brain disorder characterized by a gradual cognitive decline and neuronal deterioration. To date, the treatments available are effective only in the early stage of the disease. The AD etiology has not been completely revealed, and investigating new pathological mechanisms is essential for developing effective and safe drugs. The recreational and pharmacological properties of marijuana are known for centuries, but only recently the scientific community started to investigate the potential use of cannabinoids in AD therapy-sometimes with contradictory outcomes. Since the endocannabinoid system (ECS) is highly expressed in the hippocampus and cortex, cannabis use/abuse has often been associated with memory and learning dysfunction in vulnerable individuals. However, the latest findings in AD rodent models have shown promising effects of cannabinoids in reducing amyloid plaque deposition and stimulating hippocampal neurogenesis. Beneficial effects on several dementia-related symptoms have also been reported in clinical trials after cannabinoid treatments. Accordingly, future studies should address identifying the correct therapeutic dosage and timing of treatment from the perspective of using cannabinoids in AD therapy. The present paper aims to summarize the potential and limitations of cannabinoids as therapeutics for AD, focusing on recent pre-clinical and clinical evidence.
Identifiants
pubmed: 34204237
pii: biology10060542
doi: 10.3390/biology10060542
pmc: PMC8234911
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Neuroscience. 2016 May 26;323:35-42
pubmed: 25967266
Br J Pharmacol. 2006 Feb;147(3):281-8
pubmed: 16331291
Front Psychiatry. 2020 Nov 13;11:576877
pubmed: 33304282
J Alzheimers Dis. 2015;43(3):977-91
pubmed: 25125475
Cell Rep. 2012 Jun 28;1(6):617-23
pubmed: 22813736
Biochem Biophys Res Commun. 2017 Nov 4;493(1):451-454
pubmed: 28888984
J Med Chem. 2013 Jun 13;56(11):4798-810
pubmed: 23679955
Neural Plast. 2016;2016:9817089
pubmed: 26819779
Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9371-6
pubmed: 11470906
Philos Trans R Soc Lond B Biol Sci. 2012 Dec 5;367(1607):3326-41
pubmed: 23108550
ACS Med Chem Lett. 2011 Feb 10;2(2):91-96
pubmed: 21666860
Brain Behav Immun. 2019 Feb;76:165-181
pubmed: 30465881
NPJ Aging Mech Dis. 2016 Jun 23;2:16012
pubmed: 28721267
Eur J Neurosci. 2004 Aug;20(3):859-63
pubmed: 15255998
J Neuroinflammation. 2018 Nov 19;15(1):322
pubmed: 30453998
J Neuroinflammation. 2012 Mar 07;9:47
pubmed: 22397366
Nat Prod Rep. 2016 Nov 23;33(12):1357-1392
pubmed: 27722705
Eur J Pharmacol. 1985 Feb 26;109(2):201-12
pubmed: 2986995
Cannabis Cannabinoid Res. 2018 Mar 01;3(1):56-65
pubmed: 29607411
Mol Neurobiol. 2019 Nov;56(11):7719-7730
pubmed: 31104297
Am J Geriatr Psychiatry. 2019 Nov;27(11):1161-1173
pubmed: 31182351
Schizophr Bull. 2016 Sep;42(5):1262-9
pubmed: 26884547
Br J Pharmacol. 2007 Jul;151(5):688-700
pubmed: 17502849
J Neurosci. 2010 Jan 13;30(2):694-702
pubmed: 20071534
Alzheimers Dement (N Y). 2020 Jul 16;6(1):e12050
pubmed: 32695874
Mech Ageing Dev. 2020 Dec;192:111385
pubmed: 33129798
Lancet Neurol. 2019 Jan;18(1):88-106
pubmed: 30497964
Neurobiol Dis. 2009 May;34(2):300-7
pubmed: 19385063
J Biol Chem. 2013 Jan 4;288(1):654-65
pubmed: 23150673
Biol Psychiatry. 2016 Apr 1;79(7):557-67
pubmed: 26858214
Sci Rep. 2019 Jul 3;9(1):9621
pubmed: 31270353
Neuron. 2010 Feb 11;65(3):320-7
pubmed: 20159446
J Alzheimers Dis. 2007 Dec;12(4):291-311
pubmed: 18198416
Mol Med. 2014 Mar 14;20:29-36
pubmed: 24722782
J Neurosci Res. 2014 Dec;92(12):1669-77
pubmed: 25042014
Cold Spring Harb Perspect Med. 2011 Sep;1(1):a006189
pubmed: 22229116
Pharmacol Ther. 2013 Apr;138(1):84-102
pubmed: 23333350
J Biol Chem. 2012 Jan 6;287(2):1198-209
pubmed: 22102284
PLoS One. 2013 Sep 12;8(9):e74680
pubmed: 24069330
Neuropsychopharmacology. 2007 May;32(5):1032-41
pubmed: 17047668
Curr Med Chem. 2007;14(8):917-36
pubmed: 17430144
Semin Immunol. 2014 Oct;26(5):369-79
pubmed: 24877594
FASEB J. 2005 Oct;19(12):1704-6
pubmed: 16037095
Eur Arch Psychiatry Clin Neurosci. 2019 Feb;269(1):5-15
pubmed: 30671616
Psychopharmacology (Berl). 2015 Jul;232(14):2587-95
pubmed: 25752889
Br J Pharmacol. 2008 Jan;153(2):199-215
pubmed: 17828291
Neuropharmacology. 2016 Oct;109:254-269
pubmed: 27346209
J Med Chem. 2019 Oct 24;62(20):9078-9102
pubmed: 31609608
J Pharmacol Exp Ther. 2011 Jul;338(1):114-24
pubmed: 21505060
Front Pharmacol. 2020 May 08;11:628
pubmed: 32457622
J Neurosci. 2010 Feb 10;30(6):2017-24
pubmed: 20147530
Psychopharmacology (Berl). 2006 May;185(4):524-8
pubmed: 16521031
J Physiol. 2015 Feb 15;593(4):871-86
pubmed: 25504573
Naunyn Schmiedebergs Arch Pharmacol. 1995 Nov;352(5):576-9
pubmed: 8751088
J Neurosci. 2011 Oct 26;31(43):15560-8
pubmed: 22031901
Pharmacol Biochem Behav. 2008 Oct;90(4):501-11
pubmed: 18584858
Nature. 1996 Nov 7;384(6604):83-7
pubmed: 8900284
Biomed Pharmacother. 2017 Apr;88:745-753
pubmed: 28157650
J Alzheimers Dis. 2021;80(3):973-977
pubmed: 33612548
Neonatology. 2017;112(2):143-149
pubmed: 28564654
J Neurochem. 1993 Jul;61(1):352-5
pubmed: 8515284
Mol Pharmacol. 2011 Jun;79(6):964-73
pubmed: 21350020
Mol Pharm. 2006 Nov-Dec;3(6):773-7
pubmed: 17140265
Cold Spring Harb Perspect Med. 2012 Oct 01;2(10):
pubmed: 23028126
Mol Cell Neurosci. 2008 Aug;38(4):526-36
pubmed: 18562209
Neurochem Int. 2010 Dec;57(8):985-9
pubmed: 21034788
Br J Pharmacol. 2007 Aug;151(8):1272-9
pubmed: 17592514
J Neuroinflammation. 2012 Jan 16;9:8
pubmed: 22248049
Neurology. 2015 Jun 9;84(23):2338-46
pubmed: 25972490
Science. 2011 Nov 11;334(6057):809-13
pubmed: 22021672
Science. 2005 Oct 14;310(5746):329-32
pubmed: 16224028
J Clin Invest. 2005 Nov;115(11):3104-16
pubmed: 16224541
Mech Ageing Dev. 2015 Sep;150:55-64
pubmed: 26278494
Br J Pharmacol. 2015 Oct;172(20):4790-805
pubmed: 26218440
PLoS One. 2013;8(4):e60314
pubmed: 23565223
PLoS One. 2013 Aug 09;8(8):e70849
pubmed: 23951024
Sci Rep. 2017 Aug 4;7(1):7363
pubmed: 28779174
Neurosci Lett. 2006 Sep 1;404(3):342-6
pubmed: 16837132
Br J Pharmacol. 2007 Dec;152(7):1092-101
pubmed: 17876302
Arch Gen Psychiatry. 2008 Jun;65(6):694-701
pubmed: 18519827
Int J Geriatr Psychiatry. 1997 Sep;12(9):913-9
pubmed: 9309469
Neuroscience. 1997 Mar;77(2):299-318
pubmed: 9472392
Sci Transl Med. 2019 Jan 23;11(476):
pubmed: 30674654
PLoS One. 2015 Jun 18;10(6):e0129618
pubmed: 26086915
Cannabis Cannabinoid Res. 2017 Oct 01;2(1):265-273
pubmed: 29098189
J Neuroinflammation. 2012 Apr 26;9:79
pubmed: 22537429
Acta Neurobiol Exp (Wars). 2018;78(1):41-50
pubmed: 29694340
Brain. 2012 Jul;135(Pt 7):2245-55
pubmed: 22669080
Neuropsychopharmacology. 2009 Aug;34(9):2072-80
pubmed: 19322169
Psychopharmacology (Berl). 1995 Jun;119(3):282-90
pubmed: 7675962
Br J Pharmacol. 2015 Aug;172(16):3950-63
pubmed: 25951750
Addiction. 2020 Mar;115(3):559-572
pubmed: 31408248
Healthcare (Basel). 2020 Aug 21;8(3):
pubmed: 32839380
CNS Drugs. 2003;17(3):179-202
pubmed: 12617697
Neuropsychopharmacology. 2021 Apr;46(5):1004-1010
pubmed: 33070154
Neuropharmacology. 2017 Sep 15;124:89-104
pubmed: 28634109
Hippocampus. 2014 Jul;24(7):808-18
pubmed: 24648181
Nature. 1993 Sep 2;365(6441):61-5
pubmed: 7689702
Int J Clin Pharmacol Ther. 2016 Jul;54(7):498-501
pubmed: 27191771
Mol Psychiatry. 2017 Jan;22(1):68-75
pubmed: 27001613
Pain Ther. 2019 Jun;8(1):41-51
pubmed: 30721403
Cell. 2013 Nov 21;155(5):1154-1165
pubmed: 24267894
J Neurosci. 2003 Feb 1;23(3):907-14
pubmed: 12574419
J Alzheimers Dis. 2016 Oct 4;54(3):903-912
pubmed: 27567873
Handb Exp Pharmacol. 2005;(168):1-51
pubmed: 16596770
J Neurosci. 2003 Dec 3;23(35):11136-41
pubmed: 14657172
Neurotox Res. 2018 Feb;33(2):402-411
pubmed: 28933048
Int J Mol Sci. 2016 Dec 23;18(1):
pubmed: 28025562
Br J Pharmacol. 2014 Dec;171(23):5387-406
pubmed: 25048571
J Alzheimers Dis. 2014;42(3):973-84
pubmed: 25024327
Nat Med. 2008 Aug;14(8):843-8
pubmed: 18568033
Mol Neurobiol. 2007 Aug;36(1):26-35
pubmed: 17952647
Cell Mol Life Sci. 2006 Jun;63(12):1410-24
pubmed: 16732431
Curr Top Behav Neurosci. 2009;1:201-30
pubmed: 21104385
Curr Opin Psychol. 2021 Apr;38:49-55
pubmed: 32823178
Psychopharmacology (Berl). 2010 May;209(4):319-30
pubmed: 20217055
Cells. 2019 May 22;8(5):
pubmed: 31121907
Brain. 2011 Apr;134(Pt 4):1041-60
pubmed: 21459826
Front Psychiatry. 2020 May 13;11:413
pubmed: 32477187
Mol Pharmacol. 2004 Aug;66(2):204-8
pubmed: 15266010
Neuroreport. 2000 Jun 26;11(9):2025-9
pubmed: 10884065
Pol J Pharmacol. 2003 Sep-Oct;55(5):903-10
pubmed: 14704485
Glia. 2005 Jan 15;49(2):211-9
pubmed: 15390091
Neuron. 2018 Jun 6;98(5):935-944.e5
pubmed: 29779943
Br J Pharmacol. 2008 Jan;153(2):263-70
pubmed: 17906675
J Alzheimers Dis. 2013;35(4):847-58
pubmed: 23515018
Cell Mol Neurobiol. 2014 Jan;34(1):31-42
pubmed: 24030360
FASEB J. 2006 Nov;20(13):2405-7
pubmed: 17015409
PLoS One. 2019 Jul 23;14(7):e0220025
pubmed: 31335889
Nature. 2001 Mar 29;410(6828):588-92
pubmed: 11279497
J Alzheimers Dis. 2017;56(1):261-273
pubmed: 27886010
Neurobiol Aging. 2012 Aug;33(8):1522-32
pubmed: 21546126
Eur J Med Chem. 2019 Sep 15;178:243-258
pubmed: 31185414
Psychopharmacology (Berl). 2017 Apr;234(7):1121-1134
pubmed: 28160034
Philos Trans R Soc Lond B Biol Sci. 2014 Oct 19;369(1654):20130599
pubmed: 25225093
Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8268-73
pubmed: 9653176
J Neuroinflammation. 2015 Apr 28;12:81
pubmed: 25927213
Neuropharmacology. 2014 Jun;81:224-30
pubmed: 24384256
Mol Neurobiol. 2019 Feb;56(2):844-856
pubmed: 29802570
J Neurosci. 2005 Feb 23;25(8):1904-13
pubmed: 15728830
Cell Signal. 2002 Nov;14(11):941-53
pubmed: 12220620
Chem Phys Lipids. 2011 Feb;164(2):131-43
pubmed: 21185816
Curr Mol Pharmacol. 2019;12(3):239-248
pubmed: 30767756
Synapse. 2004 Sep 15;53(4):208-13
pubmed: 15266552
Hippocampus. 2011 May;21(5):520-31
pubmed: 20101600
Life Sci. 2021 Jan 1;264:118624
pubmed: 33096116
Eur Arch Psychiatry Clin Neurosci. 2019 Feb;269(1):37-58
pubmed: 30680487
Neurosci Lett. 2006 May 15;399(1-2):91-5
pubmed: 16490313
J Natl Compr Canc Netw. 2012 Apr;10(4):487-92
pubmed: 22491047
Chem Phys Lipids. 2002 Dec 31;121(1-2):149-58
pubmed: 12505697
N Engl J Med. 2014 Aug 28;371(9):878
pubmed: 25162900
J Alzheimers Dis. 2014;42(4):1383-96
pubmed: 25024347
Pain. 2008 Sep 30;139(1):225-236
pubmed: 18502582
J Clin Psychiatry. 2018 Oct 30;79(6):
pubmed: 30408351
Neuroscience. 2019 Sep 15;416:239-254
pubmed: 31400487
Biology (Basel). 2020 Nov 05;9(11):
pubmed: 33167441
Med Sci Law. 2020 Oct;60(4):309-314
pubmed: 32600171
Brain. 2003 Jun;126(Pt 6):1252-70
pubmed: 12764049
J Alzheimers Dis. 2016;51(1):15-9
pubmed: 26757043
J Alzheimers Dis. 2018;64(1):117-136
pubmed: 29865071
Biochem Biophys Res Commun. 2017 Aug 12;490(1):17-21
pubmed: 28571738
Cell Rep. 2012 Nov 29;2(5):1329-39
pubmed: 23122958
Biochem Pharmacol. 2018 Nov;157:169-179
pubmed: 29870711
Neurobiol Aging. 2013 Mar;34(3):791-804
pubmed: 22795792
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15670-5
pubmed: 16221768
Biochem Biophys Res Commun. 1995 Oct 4;215(1):89-97
pubmed: 7575630
Exp Gerontol. 2014 Dec;60:92-9
pubmed: 25456842
Eur J Pharmacol. 1997 May 26;327(1):R1-2
pubmed: 9185841
Neuropsychopharmacology. 2003 Oct;28(10):1760-9
pubmed: 12888772
J Ethnopharmacol. 2018 Dec 5;227:300-315
pubmed: 30205181
J Neurochem. 2004 Apr;89(1):134-41
pubmed: 15030397
J Alzheimers Dis. 2012;30(2):439-59
pubmed: 22451318
J Alzheimers Dis. 2013;35(3):525-39
pubmed: 23478312
Psychopharmacology (Berl). 2012 May;221(2):239-47
pubmed: 22083592
Neurochem Int. 2020 Nov;140:104817
pubmed: 32781098
Life Sci. 2014 Feb 27;97(1):78-90
pubmed: 24412391
Biomolecules. 2021 Mar 26;11(4):
pubmed: 33810505
Acta Neurobiol Exp (Wars). 2020;80(3):286-296
pubmed: 32990286
Sci Transl Med. 2015 Oct 14;7(309):309ra164
pubmed: 26468326
Br J Pharmacol. 2016 Jun;173(12):1899-910
pubmed: 27077495
J Clin Med Res. 2020 Jul;12(7):393-403
pubmed: 32655732
Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20270-5
pubmed: 19918051
Br J Pharmacol. 2019 May;176(10):1455-1469
pubmed: 29981240
Mol Metab. 2019 Oct;28:151-159
pubmed: 31420305
Psychopharmacology (Berl). 2013 Jan;225(2):483-94
pubmed: 22903389
Neuropharmacology. 2018 Aug;138:210-218
pubmed: 29842858
FASEB J. 2009 Jan;23(1):183-93
pubmed: 18757503
Nature. 1990 Aug 9;346(6284):561-4
pubmed: 2165569
J Neurophysiol. 2000 Jun;83(6):3287-93
pubmed: 10848548
J Neurochem. 2005 May;93(4):802-11
pubmed: 15857384
Neurobiol Learn Mem. 2008 Sep;90(2):374-81
pubmed: 18524639
Eur J Pharmacol. 2014 Apr 15;729:67-74
pubmed: 24561047