Epithelial-Mesenchymal Transition Associated with Head and Neck Squamous Cell Carcinomas: A Review.
EMT transcription factors
epithelial–mesenchymal transition
head and neck squamous cell carcinoma
inhibition
viral infections
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
17 Jun 2021
17 Jun 2021
Historique:
received:
22
04
2021
revised:
09
06
2021
accepted:
15
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
3
7
2021
Statut:
epublish
Résumé
Head and neck squamous cell carcinomas (HNSCCs) are aggressive, recurrent, and metastatic neoplasms with a high occurrence around the world and can lead to death when not treated appropriately. Several molecules and signaling pathways are involved in the malignant conversion process. Epithelial-mesenchymal transition (EMT) has been described in HNSCCs, a major type of aggressive carcinoma. EMT describes the development of epithelial cells into mesenchymal cells, which depends on several molecular interactions and signaling pathways that facilitate mesenchymal conversion. This is related to interactions with the microenvironment of the tumor, hypoxia, growth factors, matrix metalloproteinases, and the presence of viral infections. In this review, we focus on the main molecules related to EMT, their interactions with the tumor microenvironment, plasticity phenomena, epigenetic regulation, hypoxia, inflammation, their relationship with immune cells, and the inhibition of EMT in the context of HNSCCs.
Identifiants
pubmed: 34204259
pii: cancers13123027
doi: 10.3390/cancers13123027
pmc: PMC8234594
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Mol Cancer Res. 2019 Sep;17(9):1893-1909
pubmed: 31239287
Oral Oncol. 2013 Nov;49(11):1043-50
pubmed: 24035721
Int J Cancer. 2019 Sep 15;145(6):1585-1595
pubmed: 31026342
Cell. 2007 Feb 23;128(4):693-705
pubmed: 17320507
Proc Natl Acad Sci U S A. 2011 May 10;108(19):7838-43
pubmed: 21521790
J Clin Oncol. 2009 Dec 1;27(34):5848-56
pubmed: 19884536
Oral Oncol. 2018 May;80:23-32
pubmed: 29706185
Cell. 2008 May 16;133(4):704-15
pubmed: 18485877
Biochem Biophys Res Commun. 2020 Feb 19;522(4):1009-1014
pubmed: 31813546
Nat Rev Genet. 2009 May;10(5):295-304
pubmed: 19308066
Stem Cells. 2013 Oct;31(10):2073-83
pubmed: 23649588
Genes Dev. 2002 Jul 15;16(14):1779-91
pubmed: 12130538
Oncotarget. 2018 Oct 5;9(78):34708-34718
pubmed: 30410671
Biomed Res Int. 2020 Jun 22;2020:4234632
pubmed: 32685483
Oral Surg Oral Med Oral Pathol Oral Radiol. 2019 Apr;127(4):318-329
pubmed: 30598410
Nat Rev Cancer. 2007 Jun;7(6):415-28
pubmed: 17508028
J Biomed Biotechnol. 2011;2011:567305
pubmed: 22007144
Br J Cancer. 2009 May 19;100(10):1647-58
pubmed: 19401692
Kidney Int. 2009 Jun;75(12):1278-1287
pubmed: 19279556
Oncotarget. 2017 May 16;8(20):33972-33989
pubmed: 28430641
Crit Rev Oncol Hematol. 2018 Jan;121:11-22
pubmed: 29279096
J Cancer. 2020 Feb 10;11(9):2485-2495
pubmed: 32201519
Am J Pathol. 2010 Feb;176(2):528-35
pubmed: 20019188
Nature. 2010 Nov 25;468(7323):521-6
pubmed: 21057492
Am J Cancer Res. 2011;1(4):482-97
pubmed: 21984967
Genes Dev. 2014 Feb 15;28(4):317-27
pubmed: 24532712
Cell Death Differ. 2003 May;10(5):528-38
pubmed: 12728251
PLoS One. 2017 Jun 1;12(6):e0178581
pubmed: 28570699
Cancer Cell. 2012 Dec 11;22(6):699-701
pubmed: 23238008
Oncogene. 2005 Nov 10;24(49):7273-80
pubmed: 16007124
Head Neck. 2017 Dec;39(12):2573-2584
pubmed: 28963807
J Cell Biochem. 2010 Aug 1;110(5):1073-81
pubmed: 20544795
PLoS Comput Biol. 2016 Jul 18;12(7):e1005007
pubmed: 27427963
Front Med. 2018 Aug;12(4):361-373
pubmed: 30043221
Cell. 2006 Aug 25;126(4):663-76
pubmed: 16904174
Pathol Oncol Res. 2016 Oct;22(4):781-8
pubmed: 27138192
Oncol Rep. 2003 Mar-Apr;10(2):455-61
pubmed: 12579289
Proc Natl Acad Sci U S A. 1995 Jun 6;92(12):5510-4
pubmed: 7539918
Trends Cell Biol. 2019 Mar;29(3):212-226
pubmed: 30594349
Biosci Rep. 2019 Jan 22;39(1):
pubmed: 30563928
Head Neck Pathol. 2015 Mar;9(1):1-5
pubmed: 25804377
Breast Cancer Res. 2011 Feb 08;13(1):202
pubmed: 21392411
Mol Cancer. 2019 Mar 30;18(1):63
pubmed: 30927923
Future Oncol. 2015;11(5):771-83
pubmed: 25757681
J Oral Pathol Med. 2020 Nov;49(10):1019-1029
pubmed: 32740991
J Cell Sci. 2013 Jan 15;126(Pt 2):484-96
pubmed: 23178939
J Transl Med. 2015 Jun 21;13:198
pubmed: 26094024
Cancer Res. 2011 Aug 1;71(15):5317-26
pubmed: 21685475
J Clin Med. 2020 Jun 30;9(7):
pubmed: 32630033
Oncol Rep. 2014 Dec;32(6):2673-9
pubmed: 25241968
Curr Top Microbiol Immunol. 2015;391:119-49
pubmed: 26428373
Cochrane Database Syst Rev. 2017 Nov 28;11:CD011990
pubmed: 29181845
Biol Reprod. 2006 Jul;75(1):75-81
pubmed: 16540541
Cancer. 2013 Aug 15;119(16):3034-42
pubmed: 23696076
Immunol Rev. 2011 May;241(1):104-18
pubmed: 21488893
Biochem Biophys Res Commun. 2009 Feb 20;379(4):1091-6
pubmed: 19159617
Oncol Rep. 2016 Jan;35(1):261-6
pubmed: 26498709
Oncogene. 2013 Jul 18;32(29):3397-409
pubmed: 23246969
Eur Rev Med Pharmacol Sci. 2015 Dec;19(24):4858-65
pubmed: 26744878
Laryngoscope. 2015 Mar;125 Suppl 3:S1-11
pubmed: 25646683
PLoS One. 2008 Apr 30;3(4):e2037
pubmed: 18446223
J Clin Immunol. 2013 Jan;33 Suppl 1:S79-84
pubmed: 23225204
Nat Rev Cancer. 2018 May;18(5):269-282
pubmed: 29497144
BMC Cancer. 2016 Jul 08;16:431
pubmed: 27391030
Am J Physiol. 1996 Oct;271(4 Pt 1):C1172-80
pubmed: 8897823
Oncotarget. 2018 Jul 31;9(59):31516-31530
pubmed: 30140387
Otolaryngol Head Neck Surg. 2012 Oct;147(4):726-32
pubmed: 22568942
Br J Cancer. 2011 Mar 29;104(7):1160-7
pubmed: 21386845
Epigenetics. 2014 Nov;9(11):1461-72
pubmed: 25470663
Br J Cancer. 2020 Jul;123(1):101-113
pubmed: 32362655
Cancer Manag Res. 2018 Aug 10;10:2589-2604
pubmed: 30127645
Folia Histochem Cytobiol. 2006;44(3):143-54
pubmed: 16977793
Int J Oncol. 2009 Apr;34(4):897-903
pubmed: 19287946
Int J Cancer. 2015 Feb 15;136(4):982-8
pubmed: 24975135
Braz J Med Biol Res. 2019 Apr 08;52(4):e8409
pubmed: 30970087
Cell. 1993 Dec 3;75(5):843-54
pubmed: 8252621
Oral Oncol. 2013 Mar;49(3):211-5
pubmed: 23079694
Curr Pharm Des. 2014;20(11):1698-705
pubmed: 23888971
Front Oncol. 2014 May 01;4:80
pubmed: 24822169
Cell. 2018 Jul 26;174(3):716-729.e27
pubmed: 29961576
Cell. 1999 Oct 29;99(3):247-57
pubmed: 10555141
J Cancer Res Clin Oncol. 2001 Jan;127(1):59-63
pubmed: 11206273
J Oral Maxillofac Surg. 2012 Jun;70(6):1473-9
pubmed: 21864967
Int J Mol Sci. 2020 Jul 02;21(13):
pubmed: 32630820
J Biotechnol. 2015 May 20;202:3-11
pubmed: 25449012
J Biol Chem. 2013 Jul 12;288(28):20217-27
pubmed: 23703614
Philos Trans R Soc Lond B Biol Sci. 2015 Feb 5;370(1661):20140039
pubmed: 25533096
Oncotarget. 2015 Mar 30;6(9):6887-901
pubmed: 25749385
J Cancer. 2018 Jan 1;9(2):375-388
pubmed: 29344284
Carcinogenesis. 2009 Jul;30(7):1073-81
pubmed: 19468060
Nat Cell Biol. 2011 Mar;13(3):215-22
pubmed: 21278734
Cancer Cell. 2011 Nov 15;20(5):576-90
pubmed: 22094253
Cell Physiol Biochem. 2018;47(2):567-578
pubmed: 29794474
J Clin Invest. 2012 Apr;122(4):1469-86
pubmed: 22406531
J Cancer. 2020 Jan 1;11(5):1257-1269
pubmed: 31956372
Med Oncol. 2015 Jan;32(1):399
pubmed: 25433949
Braz Oral Res. 2011 May-Jun;25(3):235-40
pubmed: 21670854
Nucleic Acids Res. 2015 Jan;43(1):162-78
pubmed: 25492890
Oncogene. 2013 Apr 4;32(14):1752-60
pubmed: 22665059
Anticancer Res. 2019 Jun;39(6):2715-2720
pubmed: 31177106
J Thorac Oncol. 2011 Jan;6(1):209-17
pubmed: 21107292
Cell. 2010 Aug 6;142(3):375-86
pubmed: 20691899
PLoS One. 2014 Aug 14;9(8):e104987
pubmed: 25122124
Cell Stem Cell. 2019 Jan 3;24(1):65-78
pubmed: 30554963
Cancer Gene Ther. 2014 Sep;21(9):381-8
pubmed: 25104726
Oncotarget. 2017 Sep 6;8(49):85816-85827
pubmed: 29156759
Neoplasia. 2009 Dec;11(12):1371-82
pubmed: 20019845
Eur J Cancer Prev. 2007 Aug;16(4):348-56
pubmed: 17554208
Pathol Res Pract. 2017 May;213(5):496-501
pubmed: 28285966
Anticancer Res. 2014 Dec;34(12):7061-9
pubmed: 25503133
Cell Adh Migr. 2010 Apr-Jun;4(2):199-203
pubmed: 20168078
Anticancer Res. 2019 Nov;39(11):6307-6316
pubmed: 31704861
Proc Natl Acad Sci U S A. 2018 Jun 19;115(25):6470-6475
pubmed: 29866841
Glycobiology. 2014 Jul;24(7):579-91
pubmed: 24742667
Cell Metab. 2013 Dec 3;18(6):896-907
pubmed: 24315373
Development. 2005 Jul;132(14):3151-61
pubmed: 15983400
PLoS One. 2008 Aug 06;3(8):e2888
pubmed: 18682804
Tumori. 2010 Nov-Dec;96(6):902-10
pubmed: 21388050
Curr Biol. 1998 Nov 19;8(23):1243-52
pubmed: 9822576
Cell. 2013 Mar 28;153(1):139-52
pubmed: 23540695
Cancer Lett. 2006 Jan 8;231(1):129-37
pubmed: 16356838
Neoplasia. 2019 Feb;21(2):216-229
pubmed: 30622052
Head Neck. 2019 Jun;41(6):1918-1927
pubmed: 30620425
Clin Cancer Res. 2009 Oct 1;15(19):6018-27
pubmed: 19789323
Gene Expr Patterns. 2020 Sep;37:119127
pubmed: 32711119
Oncotarget. 2017 Jan 31;8(5):7729-7739
pubmed: 28032603
Cancer Cell. 2013 Jun 10;23(6):768-83
pubmed: 23764001
J Biomed Sci. 2020 Apr 2;27(1):46
pubmed: 32238162
Histopathology. 2012 Aug;61(2):237-46
pubmed: 22385354
Oral Oncol. 2016 Jan;52:66-74
pubmed: 26604082
Nature. 2018 Apr;556(7702):463-468
pubmed: 29670281
Oral Oncol. 2013 May;49(5):381-6
pubmed: 23357526
Oncogene. 2009 Jun 11;28(23):2245-56
pubmed: 19421142
Oral Oncol. 2012 Jun;48(6):523-9
pubmed: 22341307
Cancer Res. 2011 Mar 1;71(5):1912-23
pubmed: 21169409
Cells. 2019 Sep 20;8(10):
pubmed: 31547193
Otolaryngol Pol. 2016 Jun 30;70(3):32-43
pubmed: 27386931
Cancer Res. 2006 Sep 15;66(18):9009-16
pubmed: 16982742
Oncogene. 2008 Dec 11;27(58):7274-84
pubmed: 18806826
J Oral Pathol Med. 2015 May;44(5):337-44
pubmed: 25048179
Cancers (Basel). 2019 Dec 24;12(1):
pubmed: 31878157
Nat Cell Biol. 2019 Feb;21(2):251-262
pubmed: 30664792
Trends Cancer. 2018 Apr;4(4):273-277
pubmed: 29606311
Cell. 2007 Nov 30;131(5):861-72
pubmed: 18035408
Oral Oncol. 2012 Mar;48(3):240-8
pubmed: 22104250
Semin Oncol. 2014 Apr;41(2):217-34
pubmed: 24787294
Cancer Med. 2015 Jan;4(1):125-35
pubmed: 25315069
Biomed Pharmacother. 2019 Oct;118:109320
pubmed: 31545265
Nat Rev Genet. 2018 Feb;19(2):81-92
pubmed: 29033456
Am J Pathol. 2011 May;178(5):2389-96
pubmed: 21514449
Arch Pharm Res. 2019 Jan;42(1):14-24
pubmed: 30649699
Int J Hyperthermia. 2010;26(6):556-64
pubmed: 20707650
J Cell Biochem. 2011 Sep;112(9):2508-17
pubmed: 21557297
Anticancer Res. 2008 Mar-Apr;28(2B):1355-9
pubmed: 18505078
Dev Cell. 2009 Dec;17(6):755-73
pubmed: 20059947
Integr Biol (Camb). 2019 Jun 1;11(6):251-263
pubmed: 31329868
Cell Adh Migr. 2011 Jul-Aug;5(4):315-22
pubmed: 21785273
Adv Clin Chem. 2018;86:23-70
pubmed: 30144841
J Lipid Res. 2012 Apr;53(4):630-42
pubmed: 22308510
Hum Mol Genet. 2000 Oct;9(16):2395-402
pubmed: 11005794
Oral Dis. 2020 Apr 11;:
pubmed: 32277532
Nature. 2008 Oct 2;455(7213):627-32
pubmed: 18754011
CA Cancer J Clin. 2018 Nov;68(6):394-424
pubmed: 30207593
Nat Cell Biol. 2008 Mar;10(3):295-305
pubmed: 18297062
Cell. 2004 Jan 23;116(2):281-97
pubmed: 14744438
F1000Res. 2018 Nov 15;7:
pubmed: 30505430
Structure. 2009 Oct 14;17(10):1282-94
pubmed: 19836329
Head Neck. 2002 Aug;24(8):792-9
pubmed: 12203806
Mol Med Rep. 2021 Mar;23(3):
pubmed: 33398370
Eur Rev Med Pharmacol Sci. 2014;18(9):1361-7
pubmed: 24867514
BMC Cancer. 2014 Dec 17;14:972
pubmed: 25518919
Mol Oncol. 2016 May;10(5):663-76
pubmed: 26781944
Oncogene. 2013 Jan 17;32(3):296-306
pubmed: 22370643
Nature. 2010 Feb 25;463(7284):1035-41
pubmed: 20107439
Essays Biochem. 2007;43:165-78
pubmed: 17705800
Int J Hyperthermia. 2011;27(5):517-22
pubmed: 21609274
Biol Reprod. 1998 Mar;58(3):739-46
pubmed: 9510961
Rom J Morphol Embryol. 2017;58(3):761-766
pubmed: 29250652
Cancers (Basel). 2017 Jul 03;9(7):
pubmed: 28671620
Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):E4320-7
pubmed: 27466403
Cancer Lett. 2016 Oct 28;381(2):380-90
pubmed: 27544906
Pathol Oncol Res. 2020 Jul;26(3):1511-1518
pubmed: 31471883
Front Oncol. 2017 Jan 31;7:3
pubmed: 28197395
Life Sci. 2020 Jan 15;241:117143
pubmed: 31811855