An Overview of the Role of Long Non-Coding RNAs in Human Choriocarcinoma.
choriocarcinoma
lncRNA-based therapy
long non-coding RNA
oncogenes or tumor suppressor genes
rare cancer
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
17 Jun 2021
17 Jun 2021
Historique:
received:
27
04
2021
revised:
11
06
2021
accepted:
15
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
17
7
2021
Statut:
epublish
Résumé
Choriocarcinoma (CC), a subtype of trophoblastic disease, is a rare and highly aggressive neoplasm. There are two main CC subtypes: gestational and non-gestational, (so called when it develops as a component of a germ cell tumor or is related to a somatic mutation of a poorly differentiated carcinoma), each with very diverse biological activity. A therapeutic approach is highly effective in patients with early-stage CC. The advanced stage of the disease also has a good prognosis with around 95% of patients cured following chemotherapy. However, advancements in diagnosis and treatment are always needed to improve outcomes for patients with CC. Long non-coding (lnc) RNAs are non-coding transcripts that are longer than 200 nucleotides. LncRNAs can act as oncogenes or tumor suppressor genes. Deregulation of their expression has a key role in tumor development, angiogenesis, differentiation, migration, apoptosis, and proliferation. Furthermore, detection of cancer-associated lncRNAs in body fluids, such as blood, saliva, and urine of cancer patients, is emerging as a novel method for cancer diagnosis. Although there is evidence for the potential role of lncRNAs in a number of cancers of the female genital tract, their role in CC is poorly understood. This review summarizes the current knowledge of lncRNAs in gestational CC and how this may be applied to future therapeutic strategies in the treatment of this rare cancer.
Identifiants
pubmed: 34204445
pii: ijms22126506
doi: 10.3390/ijms22126506
pmc: PMC8235025
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
RNA, Long Noncoding
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : European Cooperation in Science and Technology
ID : CA18117
Références
Mol Cancer. 2015 Apr 25;14:94
pubmed: 25910082
Genome Biol. 2015 Jan 29;16:20
pubmed: 25630241
J Cell Biochem. 2019 Oct;120(10):18378-18387
pubmed: 31190356
FEBS J. 2016 Jun;283(12):2326-39
pubmed: 27093644
J Cell Mol Med. 2019 Jul;23(7):4738-4745
pubmed: 31062436
Cell Commun Signal. 2020 Aug 26;18(1):135
pubmed: 32843056
World J Gastroenterol. 2013 Jun 21;19(23):3658-64
pubmed: 23801869
PLoS Genet. 2013 Jun;9(6):e1003569
pubmed: 23818866
Noncoding RNA Res. 2020 May 13;5(2):77-82
pubmed: 32490292
J Biochem Mol Toxicol. 2017 Sep;31(9):
pubmed: 28544374
Biomarkers. 2016 Nov;21(7):653-9
pubmed: 27121394
Oncol Res. 2017 May 24;25(5):733-742
pubmed: 27983929
Nat Commun. 2019 Nov 21;10(1):5290
pubmed: 31754097
Proc Natl Acad Sci U S A. 1988 Jul;85(14):5011-5
pubmed: 2839827
J Clin Oncol. 2013 Jan 10;31(2):280-6
pubmed: 23233709
Genes (Basel). 2017 Mar 03;8(3):
pubmed: 28273813
PLoS One. 2009;4(3):e4995
pubmed: 19319183
J Urol. 1996 Jun;155(6):2120-7
pubmed: 8618347
Gynecol Oncol. 2014 Jul;134(1):121-8
pubmed: 24662839
Technol Cancer Res Treat. 2020 Jan-Dec;19:1533033820905823
pubmed: 32233835
Biology (Basel). 2020 Aug 07;9(8):
pubmed: 32784701
J Cell Physiol. 2019 Aug;234(10):18524-18534
pubmed: 30912138
Nat Genet. 2008 Aug;40(8):971-6
pubmed: 18587395
Cell. 2019 Jan 10;176(1-2):182-197.e23
pubmed: 30595450
Exp Mol Med. 2020 Dec;52(12):2046-2054
pubmed: 33319857
Genes (Basel). 2020 Sep 23;11(10):
pubmed: 32977396
Med Mol Morphol. 2018 Jun;51(2):102-110
pubmed: 29280012
PLoS One. 2016 Mar 29;11(3):e0151560
pubmed: 27023770
Life Sci. 2020 Dec 15;263:118525
pubmed: 33031826
Commun Biol. 2020 Feb 5;3(1):56
pubmed: 32024996
Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8403-8
pubmed: 26080435
Prostate. 2015 Dec;75(16):1886-95
pubmed: 26306723
Sci Rep. 2017 Mar 22;7(1):295
pubmed: 28331184
Prenat Diagn. 2010 Jun;30(6):497-502
pubmed: 20509147
Biomed Pharmacother. 2018 Jan;97:543-550
pubmed: 29096355
RNA. 2010 Nov;16(11):2043-50
pubmed: 20855538
Arch Gynecol Obstet. 2014 Oct;290(4):717-23
pubmed: 24748337
Mol Reprod Dev. 2012 Aug;79(8):564-72
pubmed: 22729990
Biosci Rep. 2020 Apr 30;40(4):
pubmed: 32207531
Cancer Res. 2011 Oct 15;71(20):6320-6
pubmed: 21862635
Cell Biol Int. 2019 Feb;43(2):158-166
pubmed: 30536541
Cancer Biol Ther. 2016;17(1):104-13
pubmed: 26574780
RNA. 2006 Jan;12(1):163-76
pubmed: 16301602
Front Oncol. 2020 Feb 20;10:150
pubmed: 32154165
Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12405-10
pubmed: 16894141
BMC Cancer. 2019 Jul 29;19(1):744
pubmed: 31357948
J Cell Biochem. 2019 Sep;120(9):15131-15144
pubmed: 31020694
Cell. 2007 Jun 29;129(7):1311-23
pubmed: 17604720
Future Oncol. 2009 Mar;5(2):217-31
pubmed: 19284380
Clin Chim Acta. 2015 Apr 15;444:280-8
pubmed: 25748036
Nature. 2010 Apr 15;464(7291):1071-6
pubmed: 20393566
Ann Surg Oncol. 2011 May;18(5):1243-50
pubmed: 21327457
Oncogene. 1995 Mar 16;10(6):1193-8
pubmed: 7700644
FEBS Open Bio. 2019 Jul;9(7):1212-1222
pubmed: 31037832
World J Gastroenterol. 2015 Jul 28;21(28):8527-40
pubmed: 26229396
Case Rep Oncol. 2018 Mar 14;11(1):151-158
pubmed: 29681814
Mol Pathol. 1998 Feb;51(1):21-5
pubmed: 9624415
Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8064-9
pubmed: 9653140
Am J Obstet Gynecol. 2010 Dec;203(6):531-9
pubmed: 20728069
J Cell Physiol. 2019 Dec;234(12):22648-22656
pubmed: 31183860
Curr Pharm Des. 2015;21(34):5017-28
pubmed: 26205289
Front Cell Neurosci. 2013 Oct 02;7:168
pubmed: 24106460
Clin Cancer Res. 2017 Nov 15;23(22):7130-7140
pubmed: 28899975
Nucleic Acids Res. 2019 Jan 8;47(D1):D135-D139
pubmed: 30371849
J Mol Med (Berl). 2013 Jul;91(7):791-801
pubmed: 23529762
Nature. 2017 Oct 12;550(7675):280-284
pubmed: 28976959
Cell Tissue Res. 2018 Jan;371(1):55-71
pubmed: 29079882
J Urol. 2016 Oct;196(4):1053-60
pubmed: 27140073
Mol Ther. 2014 Apr;22(4):692-701
pubmed: 24352214
Int J Cancer. 2011 Aug 15;129(4):773-9
pubmed: 21400503
Diagn Pathol. 2019 Aug 17;14(1):93
pubmed: 31421690
Neoplasma. 2019 Mar 31;66(4):532-542
pubmed: 30943748
Int J Mol Med. 2014 Feb;33(2):325-32
pubmed: 24285342
Int J Mol Sci. 2019 Nov 30;20(23):
pubmed: 31801211
Trends Mol Med. 2018 Mar;24(3):257-277
pubmed: 29449148
J Cell Physiol. 2020 Mar;235(3):2973-2985
pubmed: 31674022
EBioMedicine. 2016 Nov;13:9-10
pubmed: 27840010
Proc Natl Acad Sci U S A. 2004 Jul 6;101(27):10024-9
pubmed: 15226497
Biomed Res Int. 2016;2016:5902678
pubmed: 27672656
Drug Deliv. 2018 Nov;25(1):1234-1257
pubmed: 29801422
J Mol Med (Berl). 2019 Mar;97(3):355-367
pubmed: 30617930
RNA Biol. 2013 Jun;10(6):925-33
pubmed: 23696037
Sci Rep. 2020 Feb 4;10(1):1794
pubmed: 32020014
Mol Cancer. 2017 Jun 14;16(1):104
pubmed: 28615056
Oncol Rep. 2015 Nov;34(5):2439-44
pubmed: 26351770
Biochim Biophys Acta. 2016 Jan;1859(1):192-9
pubmed: 26434412
Mod Pathol. 2014 Oct;27(10):1310-20
pubmed: 24603586
Cancer Res. 2012 Mar 1;72(5):1126-36
pubmed: 22258453
Cancer Manag Res. 2018 Jul 02;10:1817-1826
pubmed: 29997441
Cell Death Dis. 2019 Mar 20;10(4):270
pubmed: 30894512
Mol Cancer. 2017 Jun 21;16(1):107
pubmed: 28637507
N Engl J Med. 2018 Jul 5;379(1):11-21
pubmed: 29972753
Nature. 1993 Oct 21;365(6448):764-7
pubmed: 7692308
J Cell Physiol. 2018 Jun;233(6):4852-4863
pubmed: 29152741
Curr Pharm Biotechnol. 2011 Dec;12(12):2203-13
pubmed: 21619536
Dis Markers. 2017;2017:7243968
pubmed: 28634418
J Exp Clin Cancer Res. 2020 Mar 17;39(1):51
pubmed: 32183847
Cell. 2014 Oct 23;159(3):647-61
pubmed: 25307932
Hum Genet. 2011 Aug;130(2):223-36
pubmed: 21626138
Adv Drug Deliv Rev. 2020;159:344-363
pubmed: 32622021
North Clin Istanb. 2019 Nov 22;7(1):81-86
pubmed: 32232211
Theranostics. 2018 Apr 15;8(10):2814-2829
pubmed: 29774077
Genomics Proteomics Bioinformatics. 2016 Feb;14(1):42-54
pubmed: 26883671
Clin Exp Reprod Med. 2017 Mar;44(1):40-46
pubmed: 28428943
Int J Gynaecol Obstet. 1998 Apr;60 Suppl 1:S1-8
pubmed: 9833609
Cell Stem Cell. 2015 May 7;16(5):504-16
pubmed: 25891907
Cell Biochem Funct. 2019 Dec;37(8):591-597
pubmed: 31512281
J Cell Biochem. 2015 Apr;116(4):542-50
pubmed: 25358633
Nat Commun. 2014 Nov 19;5:5323
pubmed: 25406515
FEBS Lett. 2011 Feb 18;585(4):671-6
pubmed: 21266177
Oncogene. 2003 Sep 11;22(39):8031-41
pubmed: 12970751
Funct Integr Genomics. 2018 May;18(3):261-275
pubmed: 29374362
Oncol Rep. 2014 Jul;32(1):277-85
pubmed: 24859196
J Cell Mol Med. 2017 May;21(5):955-967
pubmed: 27878953
Nat Cell Biol. 2019 May;21(5):542-551
pubmed: 31048766
Cancers (Basel). 2020 Dec 19;12(12):
pubmed: 33352769
Science. 2017 Jan 6;355(6320):
pubmed: 27980086
Mol Ther Nucleic Acids. 2018 Mar 2;10:269-276
pubmed: 29499939
Antisense Nucleic Acid Drug Dev. 2000 Apr;10(2):117-21
pubmed: 10805163
Expert Opin Drug Discov. 2018 Sep;13(9):837-849
pubmed: 30078338
Noncoding RNA. 2019 Apr 19;5(2):
pubmed: 31010202
Expert Rev Neurother. 2017 Oct;17(10):955-962
pubmed: 28884620
Int J Clin Exp Pathol. 2019 May 01;12(5):1609-1617
pubmed: 31933978
Lancet Oncol. 2007 Jul;8(7):642-50
pubmed: 17613426