Effects of a Diet Based on Foods from Symbiotic Agriculture on the Gut Microbiota of Subjects at Risk for Metabolic Syndrome.


Journal

Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595

Informations de publication

Date de publication:
17 Jun 2021
Historique:
received: 25 05 2021
accepted: 14 06 2021
entrez: 2 7 2021
pubmed: 3 7 2021
medline: 13 8 2021
Statut: epublish

Résumé

Diet is a major driver of gut microbiota variation and plays a role in metabolic disorders, including metabolic syndrome (MS). Mycorrhized foods from symbiotic agriculture (SA) exhibit improved nutritional properties, but potential benefits have never been investigated in humans. We conducted a pilot interventional study on 60 adults with ≥ 1 risk factors for MS, of whom 33 consumed SA-derived fresh foods and 27 received probiotics over 30 days, with a 15-day follow-up. Stool, urine and blood were collected over time to explore changes in gut microbiota, metabolome, and biochemical, inflammatory and immunologic parameters; previous dietary habits were investigated through a validated food-frequency questionnaire. The baseline microbiota showed alterations typical of metabolic disorders, mainly an increase in

Identifiants

pubmed: 34204572
pii: nu13062081
doi: 10.3390/nu13062081
pmc: PMC8235411
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Références

Nutrients. 2020 Jan 02;12(1):
pubmed: 31906594
J Am Heart Assoc. 2018 Mar 26;7(7):
pubmed: 29581220
Anal Bioanal Chem. 2017 Feb;409(5):1405-1413
pubmed: 27900420
Microb Cell Fact. 2020 Mar 6;19(1):61
pubmed: 32143621
Nutrients. 2019 Dec 10;11(12):
pubmed: 31835452
Cell. 2016 Jun 2;165(6):1332-1345
pubmed: 27259147
Curr Pharm Biotechnol. 2015;16(8):738-46
pubmed: 26044864
Cancers (Basel). 2021 Mar 09;13(5):
pubmed: 33803268
Nucleic Acids Res. 2013 Jan 7;41(1):e1
pubmed: 22933715
NPJ Biofilms Microbiomes. 2019 Oct 4;5(1):28
pubmed: 31602309
Dis Colon Rectum. 2010 Nov;53(11):1530-6
pubmed: 20940602
Genome Med. 2016 Apr 21;8(1):43
pubmed: 27102666
Cell Host Microbe. 2016 May 11;19(5):731-43
pubmed: 27173935
Front Microbiol. 2015 Oct 27;6:1151
pubmed: 26579078
Nat Rev Gastroenterol Hepatol. 2019 Jan;16(1):35-56
pubmed: 30262901
Nat Med. 2019 Jul;25(7):1096-1103
pubmed: 31263284
Ann Oncol. 2009 Mar;20(3):581-90
pubmed: 18842615
Gut. 2021 Mar;70(3):595-605
pubmed: 33051190
Nutrients. 2020 May 28;12(6):
pubmed: 32481645
Food Funct. 2020 May 1;11(5):3879-3894
pubmed: 32421119
Br J Nutr. 2016 Jul;116(1):80-93
pubmed: 27151248
Gastroenterology. 2012 Oct;143(4):913-6.e7
pubmed: 22728514
Nutrients. 2019 Jun 16;11(6):
pubmed: 31208147
Sci Rep. 2020 Jun 22;10(1):10085
pubmed: 32572149
Biotechniques. 2004 May;36(5):808-12
pubmed: 15152600
Nat Methods. 2016 Jul;13(7):581-3
pubmed: 27214047
J Am Coll Cardiol. 2010 Sep 28;56(14):1113-32
pubmed: 20863953
J Nutr. 2011 Aug;141(8):1552-8
pubmed: 21628636
Adv Nutr. 2020 Mar 1;11(2):293-326
pubmed: 31578550
Diabetes Care. 2012 Nov;35(11):2402-11
pubmed: 23093685
Gut Microbes. 2021 Jan-Dec;13(1):1-19
pubmed: 33557667
R J. 2016 Aug;8(1):289-317
pubmed: 27818791
Tumori. 2003 Nov-Dec;89(6):594-607
pubmed: 14870824
Bioinformatics. 2005 Jun 1;21(11):2789-90
pubmed: 15797915
Circulation. 2009 Oct 20;120(16):1640-5
pubmed: 19805654
Sci Rep. 2017 Oct 20;7(1):13670
pubmed: 29057986
Cell Metab. 2017 Oct 3;26(4):611-619.e6
pubmed: 28978426
Br J Cancer. 2015 Feb 3;112(3):446-54
pubmed: 25490523
Microbiome. 2018 Sep 24;6(1):172
pubmed: 30249275
Int J Epidemiol. 1997;26 Suppl 1:S152-60
pubmed: 9126543
Gut. 2016 Nov;65(11):1812-1821
pubmed: 26416813
Curr Biol. 2016 Jun 6;26(11):1480-5
pubmed: 27185560
Br J Nutr. 2007 Aug;98(2):406-15
pubmed: 17403268
Nature. 2018 Oct;562(7728):583-588
pubmed: 30356187
Gut. 2019 Feb;68(2):248-262
pubmed: 30007918
Nutrients. 2020 Jan 01;12(1):
pubmed: 31906372
BMC Bioinformatics. 2012 Feb 14;13:31
pubmed: 22333067
Nutrients. 2020 Nov 14;12(11):
pubmed: 33202550
Curr Opin Lipidol. 2002 Feb;13(1):3-9
pubmed: 11790957
PLoS One. 2019 Jul 18;14(7):e0219489
pubmed: 31318902
Nucleic Acids Res. 2007 Jan;35(Database issue):D521-6
pubmed: 17202168
Int J Biol Sci. 2021 Jan 1;17(2):487-497
pubmed: 33613107
Nat Commun. 2014 Apr 15;5:3654
pubmed: 24736369
Nat Rev Endocrinol. 2019 Feb;15(2):69-70
pubmed: 30602737
J Natl Cancer Inst. 2013 Dec 18;105(24):1907-11
pubmed: 24316595
BMJ Open Diabetes Res Care. 2020 Apr;8(1):
pubmed: 32332068
Nature. 2012 Oct 4;490(7418):55-60
pubmed: 23023125
J Clin Invest. 2019 Oct 1;129(10):4050-4057
pubmed: 31573550
Front Cell Infect Microbiol. 2015 Nov 20;5:84
pubmed: 26636046
Nutrients. 2019 Oct 25;11(11):
pubmed: 31731473
Public Health Nutr. 2002 Dec;5(6B):1113-24
pubmed: 12639222
Br J Nutr. 2013 Sep 14;110(5):810-22
pubmed: 23452466
Int J Cancer. 2020 Dec 15;147(12):3384-3393
pubmed: 32580250
EMBO Rep. 2020 Aug 5;21(8):e51069
pubmed: 32734701
Curr Med Chem. 2012;19(21):3523-31
pubmed: 22680628
Nutrients. 2019 Dec 04;11(12):
pubmed: 31817158
Front Pharmacol. 2020 Mar 12;11:258
pubmed: 32226382
Nutr Metab Cardiovasc Dis. 2006 Apr;16(3):186-201
pubmed: 16580586
Nature. 2020 Nov;587(7834):448-454
pubmed: 33149306
PeerJ. 2016 Oct 18;4:e2584
pubmed: 27781170
Metabolism. 2015 Feb;64(2):182-9
pubmed: 25456095
Gut Microbes. 2018;9(3):189-201
pubmed: 29144833
Cell Rep. 2019 Jan 2;26(1):222-235.e5
pubmed: 30605678
J Clin Med. 2019 Apr 04;8(4):
pubmed: 30987356
J Clin Endocrinol Metab. 2016 Jan;101(1):233-42
pubmed: 26505825
Cell. 2016 Mar 24;165(1):111-124
pubmed: 26972052
J Med Food. 2019 Dec;22(12):1199-1207
pubmed: 31747330
Nutrients. 2020 Apr 15;12(4):
pubmed: 32326604
J Am Diet Assoc. 2007 Jul;107(7):1233-9
pubmed: 17604756
Trends Microbiol. 2016 Jul;24(7):523-524
pubmed: 26996766
Nature. 2011 Apr 7;472(7341):57-63
pubmed: 21475195
Genome Biol. 2017 Apr 13;18(1):70
pubmed: 28407784
Obesity (Silver Spring). 2012 Nov;20(11):2257-61
pubmed: 22546742
Gut. 2020 Jul;69(7):1218-1228
pubmed: 32066625
Nat Commun. 2017 Dec 5;8(1):1784
pubmed: 29209090
Nat Med. 2021 Feb;27(2):333-343
pubmed: 33574608
PLoS One. 2014 Sep 22;9(9):e107294
pubmed: 25244618
Nat Rev Microbiol. 2019 Dec;17(12):742-753
pubmed: 31541197
Nat Biotechnol. 2019 Aug;37(8):852-857
pubmed: 31341288
PLoS One. 2013 Sep 04;8(9):e73076
pubmed: 24023812

Auteurs

Silvia Turroni (S)

Department of Pharmacy and Biotechnology, University of Bologna, via Belmeloro, 6, 40126 Bologna, Italy.

Elisabetta Petracci (E)

Biostatistics and Clinical Trial Unit, Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori"-IRST S.r.l., IRCCS, via P. Maroncelli, 40, 47014 Meldola, Italy.

Valeria Edefonti (V)

Branch of Medical Statistics, Biometry, and Epidemiology "G.A. Maccacaro", Department of Clinical Sciences and Community Health, Università degli Studi di Milano, via A. Vanzetti, 5, 20133 Milano, Italy.

Anna M Giudetti (AM)

Department of Biological and Environmental Sciences and Technologies, University of Salento, via Province of Lecce-Monteroni, 73100 Lecce, Italy.

Federica D'Amico (F)

Department of Pharmacy and Biotechnology, University of Bologna, via Belmeloro, 6, 40126 Bologna, Italy.
Department of Medical and Surgical Sciences, University of Bologna, via Massarenti, 9, 40138 Bologna, Italy.

Lisa Paganelli (L)

Donna Impresa Coldiretti Forlì-Cesena e Rimini, via E. Forlanini, 11, 47121 Forli, Italy.

Giusto Giovannetti (G)

Centro Colture Sperimentali, CCS Aosta S.r.l., Frazione Olleyes 9, 11020 Quart, Italy.

Laura Del Coco (L)

Department of Biological and Environmental Sciences and Technologies, University of Salento, via Province of Lecce-Monteroni, 73100 Lecce, Italy.

Francesco P Fanizzi (FP)

Department of Biological and Environmental Sciences and Technologies, University of Salento, via Province of Lecce-Monteroni, 73100 Lecce, Italy.

Simone Rampelli (S)

Department of Pharmacy and Biotechnology, University of Bologna, via Belmeloro, 6, 40126 Bologna, Italy.

Debora Guerra (D)

Department of Medical Oncology, Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori"-IRST S.r.l., IRCCS, via P. Maroncelli, 40, 47014 Meldola, Italy.

Claudia Rengucci (C)

Bioscience Laboratory, Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori"-IRST S.r.l., IRCCS, via P. Maroncelli, 40, 47014 Meldola, Italy.

Jenny Bulgarelli (J)

Immunotherapy, Cell Therapy and Biobank Unit, Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori"-IRST S.r.l., IRCCS, via P. Maroncelli, 40, 47014 Meldola, Italy.

Marcella Tazzari (M)

Immunotherapy, Cell Therapy and Biobank Unit, Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori"-IRST S.r.l., IRCCS, via P. Maroncelli, 40, 47014 Meldola, Italy.

Nicoletta Pellegrini (N)

Department of Agricultural, Food, Environmental and Animal Sciences, Università di Udine, via delle Scienze 206, 33100 Udine, Italy.

Monica Ferraroni (M)

Branch of Medical Statistics, Biometry, and Epidemiology "G.A. Maccacaro", Department of Clinical Sciences and Community Health, Università degli Studi di Milano, via A. Vanzetti, 5, 20133 Milano, Italy.

Oriana Nanni (O)

Biostatistics and Clinical Trial Unit, Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori"-IRST S.r.l., IRCCS, via P. Maroncelli, 40, 47014 Meldola, Italy.

Patrizia Serra (P)

Biostatistics and Clinical Trial Unit, Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori"-IRST S.r.l., IRCCS, via P. Maroncelli, 40, 47014 Meldola, Italy.

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