In Vitro Effects of Sulforaphane on Interferon-Driven Inflammation and Exploratory Evaluation in Two Healthy Volunteers.
Adult
Cell Line, Tumor
Female
Gene Expression
/ drug effects
Genotype
Glutathione Transferase
/ metabolism
Healthy Volunteers
Hepatocytes
/ drug effects
Humans
Immunity, Innate
/ drug effects
Inflammation
/ drug therapy
Interferons
/ adverse effects
Isothiocyanates
/ metabolism
Male
Membrane Proteins
/ metabolism
Sulfoxides
/ metabolism
GSTM1
STING
interferon signature
sulforaphane
type I interferons
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
12 Jun 2021
12 Jun 2021
Historique:
received:
14
04
2021
revised:
27
05
2021
accepted:
10
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
14
7
2021
Statut:
epublish
Résumé
Interferonopathies are rare genetic conditions defined by systemic inflammatory episodes caused by innate immune system activation in the absence of pathogens. Currently, no targeted drugs are authorized for clinical use in these diseases. In this work, we studied the contribution of sulforaphane (SFN), a cruciferous-derived bioactive molecule, in the modulation of interferon-driven inflammation in an immortalized human hepatocytes (IHH) line and in two healthy volunteers, focusing on
Identifiants
pubmed: 34204601
pii: molecules26123602
doi: 10.3390/molecules26123602
pmc: PMC8231268
pii:
doi:
Substances chimiques
Isothiocyanates
0
Membrane Proteins
0
STING1 protein, human
0
Sulfoxides
0
Interferons
9008-11-1
Glutathione Transferase
EC 2.5.1.18
glutathione S-transferase M1
EC 2.5.1.18
sulforaphane
GA49J4310U
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : IRCCS Burlo Garofolo
ID : RC#24/2017 and 07/2014
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