Previous SARS-CoV-2 Infection Increases B.1.1.7 Cross-Neutralization by Vaccinated Individuals.
Adult
Aged
Aged, 80 and over
Antibodies, Neutralizing
/ blood
Antibodies, Viral
/ immunology
COVID-19
/ blood
COVID-19 Serological Testing
/ statistics & numerical data
COVID-19 Vaccines
/ administration & dosage
Cross Reactions
/ immunology
Female
Humans
Immunity, Humoral
Male
Middle Aged
Neutralization Tests
/ statistics & numerical data
Prospective Studies
SARS-CoV-2
/ genetics
Vaccination
/ statistics & numerical data
B.1.1.7 variant
SARS-CoV-2
humoral response
neutralization
pseudovirus
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
12 06 2021
12 06 2021
Historique:
received:
02
05
2021
revised:
05
06
2021
accepted:
10
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
16
7
2021
Statut:
epublish
Résumé
With the spread of new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there is a need to assess the protection conferred by both previous infections and current vaccination. Here we tested the neutralizing activity of infected and/or vaccinated individuals against pseudoviruses expressing the spike of the original SARS-CoV-2 isolate Wuhan-Hu-1 (WH1), the D614G mutant and the B.1.1.7 variant. Our data show that parameters of natural infection (time from infection and nature of the infecting variant) determined cross-neutralization. Uninfected vaccinees showed a small reduction in neutralization against the B.1.1.7 variant compared to both the WH1 strain and the D614G mutant. Interestingly, upon vaccination, previously infected individuals developed more robust neutralizing responses against B.1.1.7, suggesting that vaccines can boost the neutralization breadth conferred by natural infection.
Identifiants
pubmed: 34204754
pii: v13061135
doi: 10.3390/v13061135
pmc: PMC8231627
pii:
doi:
Substances chimiques
Antibodies, Neutralizing
0
Antibodies, Viral
0
COVID-19 Vaccines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Departament de Salut of the Generalitat de Catalunya
ID : SLD016
Organisme : Departament de Salut of the Generalitat de Catalunya
ID : SLD015
Organisme : Spanish Health Institute Carlos III
ID : PI17/01518
Organisme : Spanish Health Institute Carlos III
ID : PI20/00093
Organisme : Spanish Health Institute Carlos III
ID : PI18/01332
Organisme : CERCA Programme/Generalitat de Catalunya
ID : 2017 SGR 252
Organisme : National Agency for Research and Development of Chile
ID : 72180406
Organisme : Grifols
ID : N/A
Organisme : crowdfunding initiatives #joemcorono
ID : N/A
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