An
Ago2
Dcr2
RNAi
arbovirus replication
exo-siRNA pathway
knockout cell line
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
03 06 2021
03 06 2021
Historique:
received:
28
04
2021
revised:
19
05
2021
accepted:
30
05
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
19
8
2021
Statut:
epublish
Résumé
Mosquitoes are known as important vectors of many arthropod-borne (arbo)viruses causing disease in humans. These include dengue (DENV) and Zika (ZIKV) viruses. The exogenous small interfering (si)RNA (exo-siRNA) pathway is believed to be the main antiviral defense in arthropods, including mosquitoes. During infection, double-stranded RNAs that form during viral replication and infection are cleaved by the enzyme Dicer 2 (Dcr2) into virus-specific 21 nt vsiRNAs, which are subsequently loaded into Argonaute 2 (Ago2). Ago2 then targets and subsequently cleaves complementary RNA sequences, resulting in degradation of the target viral RNA. Although various studies using silencing approaches have supported the antiviral activity of the exo-siRNA pathway in mosquitoes, and despite strong similarities between the siRNA pathway in the
Identifiants
pubmed: 34205194
pii: v13061066
doi: 10.3390/v13061066
pmc: PMC8227176
pii:
doi:
Substances chimiques
Argonaute Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Medical Research Council
ID : MR/R010315/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 096062
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/I/00007033
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12014/8
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/I/00007032
Pays : United Kingdom
Références
Nat Immunol. 2006 Jun;7(6):590-7
pubmed: 16554838
J Virol. 2015 Nov;89(21):11030-45
pubmed: 26311875
Nucleic Acids Res. 1998 Nov 1;26(21):4983-8
pubmed: 9776763
J Gen Virol. 2012 Feb;93(Pt 2):223-234
pubmed: 22012464
BMC Genomics. 2017 Jan 19;18(1):101
pubmed: 28103802
Virus Res. 2004 Jun 1;102(1):65-74
pubmed: 15068882
Biol Open. 2014 Jan 15;3(1):42-9
pubmed: 24326186
Bioinformatics. 2013 Aug 1;29(15):1902-3
pubmed: 23709497
Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):13863-13868
pubmed: 27849599
Cells. 2018 Nov 01;7(11):
pubmed: 30388825
BMC Microbiol. 2008 Mar 17;8:47
pubmed: 18366655
Front Microbiol. 2019 Jan 23;10:22
pubmed: 30728812
PLoS Negl Trop Dis. 2010 Oct 26;4(10):e856
pubmed: 21049065
PLoS Negl Trop Dis. 2017 Oct 17;11(10):e0006010
pubmed: 29040304
Curr Opin Virol. 2015 Dec;15:119-26
pubmed: 26629932
Trends Parasitol. 2016 Mar;32(3):177-186
pubmed: 26626596
PLoS Negl Trop Dis. 2016 Feb 25;10(2):e0004452
pubmed: 26914027
Mol Cell. 2009 Nov 13;36(3):431-44
pubmed: 19917251
J Virol Methods. 2008 Mar;148(1-2):265-70
pubmed: 18054090
PLoS Negl Trop Dis. 2017 Jul 17;11(7):e0005760
pubmed: 28715413
PLoS Pathog. 2009 Jul;5(7):e1000502
pubmed: 19578437
PLoS Negl Trop Dis. 2014 Apr 24;8(4):e2823
pubmed: 24762775
Future Microbiol. 2011 Mar;6(3):265-77
pubmed: 21449839
Curr Opin Insect Sci. 2015 Apr 1;8:111-120
pubmed: 26034705
PLoS Negl Trop Dis. 2016 Oct 5;10(10):e0005048
pubmed: 27706161
J Gen Virol. 2013 Jul;94(Pt 7):1680-1689
pubmed: 23559478
Jpn J Infect Dis. 2017 Jan 24;70(1):38-44
pubmed: 27169949
J Virol. 2006 Dec;80(23):11723-32
pubmed: 16971436
Genes Dev. 2007 Jul 1;21(13):1603-8
pubmed: 17606638
Cell Host Microbe. 2018 Jul 11;24(1):57-68.e3
pubmed: 29934091
Cell Host Microbe. 2009 Apr 23;5(4):365-75
pubmed: 19380115
Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18915-20
pubmed: 23027947
Methods Mol Biol. 2014;1173:33-49
pubmed: 24920358
J Immunol. 2018 Nov 15;201(10):3058-3072
pubmed: 30305326
Curr Biol. 2007 Jul 17;17(14):1265-72
pubmed: 17604629
PLoS Negl Trop Dis. 2017 Jan 6;11(1):e0005272
pubmed: 28060823
PLoS Pathog. 2009 Feb;5(2):e1000299
pubmed: 19214215
Methods Enzymol. 2007;427:139-54
pubmed: 17720483
Sci Adv. 2020 Feb 05;6(6):eaax7989
pubmed: 32076641
Viruses. 2018 Feb 18;10(2):
pubmed: 29463033
J Gen Virol. 2018 Dec;99(12):1739-1745
pubmed: 30394867
Viruses. 2020 Jul 11;12(7):
pubmed: 32664591
Trends Microbiol. 2018 May;26(5):447-461
pubmed: 29395729
PLoS Pathog. 2016 Dec 29;12(12):e1006017
pubmed: 28033427
J Virol. 2013 Feb;87(3):1631-48
pubmed: 23175368
J Gen Virol. 2006 Nov;87(Pt 11):3397-3407
pubmed: 17030876
PLoS Negl Trop Dis. 2021 Feb 16;15(2):e0008524
pubmed: 33591970
Viruses. 2015 Feb 17;7(2):820-43
pubmed: 25690800
J Virol. 2014 May;88(9):4687-97
pubmed: 24522909
Cell Res. 2012 Apr;22(4):624-36
pubmed: 22410795
Pathogens. 2020 Feb 27;9(3):
pubmed: 32120897
mSphere. 2017 May 3;2(3):
pubmed: 28497119
PLoS Negl Trop Dis. 2019 Nov 6;13(11):e0007346
pubmed: 31693659
PLoS Negl Trop Dis. 2010 Oct 26;4(10):e848
pubmed: 21049014