Molecular Pathomechanisms of Impaired Flow-Induced Constriction of Cerebral Arteries Following Traumatic Brain Injury: A Potential Impact on Cerebral Autoregulation.
CYP450 4A
TXA2 receptors
arachidonic acid
autoregulation
diameter
hemodynamic forces
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
21 Jun 2021
21 Jun 2021
Historique:
received:
30
04
2021
revised:
11
06
2021
accepted:
16
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
3
8
2021
Statut:
epublish
Résumé
(1) Background: Traumatic brain injury (TBI) frequently occurs worldwide, resulting in high morbidity and mortality. Here, we hypothesized that TBI impairs an autoregulatory mechanism, namely the flow-induced constriction of isolated rat middle cerebral arteries (MCAs). (2) Methods: TBI was induced in anaesthetized rats by weight drop model, and then MCAs were isolated and transferred into a pressure-flow chamber. The internal diameter was measured by a video-microscopy. (3) Results: In MCAs from intact rats, increases in flow and pressure + flow elicited constrictions (-26 ± 1.9 µm and -52 ± 2.8 µm,
Identifiants
pubmed: 34205652
pii: ijms22126624
doi: 10.3390/ijms22126624
pmc: PMC8234931
pii:
doi:
Substances chimiques
Receptors, Thromboxane A2, Prostaglandin H2
0
Cytochrome P-450 CYP4A
EC 1.14.15.3
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
J Trauma. 2005 Dec;59(6):1521-31
pubmed: 16394936
Am J Physiol. 1994 May;266(5 Pt 2):H2098-107
pubmed: 8203608
Circ Res. 2000 Jul 7;87(1):60-5
pubmed: 10884373
J Cereb Blood Flow Metab. 2014 Dec;34(12):1887-97
pubmed: 25248835
Stroke. 1999 Sep;30(9):1949-54
pubmed: 10471449
Am J Physiol Heart Circ Physiol. 2002 Dec;283(6):H2260-7
pubmed: 12388265
Elife. 2019 Sep 24;8:
pubmed: 31549965
Arch Mal Coeur Vaiss. 2005 Sep;98(9):913-21
pubmed: 16231579
J Biol Chem. 1989 Jul 15;264(20):11658-62
pubmed: 2501294
Nat Rev Neurol. 2013 Apr;9(4):231-6
pubmed: 23443846
J Neurophysiol. 1997 Aug;78(2):651-9
pubmed: 9307102
Am J Physiol Heart Circ Physiol. 2011 May;300(5):H1557-65
pubmed: 21257913
J Neurotrauma. 1998 Nov;15(11):973-84
pubmed: 9840770
Circ Res. 1990 May;66(5):1445-8
pubmed: 2335036
Eur J Pharmacol. 2004 Feb 23;486(3):297-306
pubmed: 14985052
J Neurotrauma. 2017 Jul 15;34(14):2315-2319
pubmed: 28249552
Am J Physiol Heart Circ Physiol. 2020 Jul 1;319(1):H42-H50
pubmed: 32412783
J Neurotrauma. 2018 Apr 1;35(7):930-939
pubmed: 29179622
J Pharm Sci Exp Pharmacol. 2017;2017(1):21-27
pubmed: 29333537
J Neurosci Methods. 2005 Jun 15;144(2):257-63
pubmed: 15910986
Endocrinology. 2011 Dec;152(12):4927-36
pubmed: 22028445
Am J Physiol Heart Circ Physiol. 2013 Dec;305(12):H1698-708
pubmed: 24097425
J Cereb Blood Flow Metab. 1984 Sep;4(3):447-57
pubmed: 6470059
FASEB J. 2002 Jan;16(1):72-6
pubmed: 11772938
Front Neurosci. 2016 Oct 20;10:470
pubmed: 27812317
Accid Anal Prev. 2021 Mar;152:105987
pubmed: 33549974
Neurobiol Aging. 2015 Dec;36(12):3269-3277
pubmed: 26346140
Am J Physiol. 1996 Jan;270(1 Pt 2):R228-37
pubmed: 8769806
Am J Physiol Heart Circ Physiol. 2021 Apr 1;320(4):H1609-H1624
pubmed: 33666506
MMWR Surveill Summ. 2011 May 6;60(5):1-32
pubmed: 21544045
Acta Neurochir Suppl (Wien). 1994;60:421-4
pubmed: 7976607
Int J Mol Sci. 2019 Jun 30;20(13):
pubmed: 31262044
J Cereb Blood Flow Metab. 2011 Oct;31(10):2096-105
pubmed: 21610722
Am J Physiol Heart Circ Physiol. 2008 Jan;294(1):H107-20
pubmed: 17906097
Prostaglandins Other Lipid Mediat. 2020 Feb;146:106389
pubmed: 31689497
J Head Trauma Rehabil. 2005 May-Jun;20(3):187-8
pubmed: 15908818
Anesth Analg. 2003 Nov;97(5):1340-6
pubmed: 14570649
Am J Physiol Heart Circ Physiol. 2016 Nov 1;311(5):H1118-H1131
pubmed: 27614225
Acta Physiol (Oxf). 2012 Jul;205(3):363-71
pubmed: 22212496
Atherosclerosis. 2010 Jan;208(1):43-9
pubmed: 19615686
J Neurosurg. 1994 Feb;80(2):291-300
pubmed: 8283269
J Cereb Blood Flow Metab. 2013 Nov;33(11):1732-42
pubmed: 23942363
J Pharmacol Exp Ther. 1989 Jan;248(1):229-32
pubmed: 2492340
Curr Opin Neurol. 2010 Jun;23(3):293-9
pubmed: 20168229
J Vasc Res. 2012;49(5):375-89
pubmed: 22739136