Diversity of Epithelial-Mesenchymal Phenotypes in Circulating Tumour Cells from Prostate Cancer Patient-Derived Xenograft Models.
SERPINE1
circulating tumour cell (CTC)
epithelial-mesenchymal plasticity (EMP)
kallikrein-related peptidase 3 (KLK3)
metastasis
patient-derived xenograft (PDX)
plasminogen activator inhibitor-1 (PAI-1)
prostate cancer
prostate-specific antigen (PSA)
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
01 Jun 2021
01 Jun 2021
Historique:
received:
02
02
2021
revised:
29
03
2021
accepted:
12
04
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
3
7
2021
Statut:
epublish
Résumé
Metastasis is the leading cause of cancer-related deaths worldwide. The epithelial-mesenchymal plasticity (EMP) status of primary tumours has relevance to metastatic potential and therapy resistance. Circulating tumour cells (CTCs) provide a window into the metastatic process, and molecular characterisation of CTCs in comparison to their primary tumours could lead to a better understanding of the mechanisms involved in the metastatic cascade. In this study, paired blood and tumour samples were collected from four prostate cancer patient-derived xenograft (PDX) models (BM18, LuCaP70, LuCaP96, LuCaP105) and assessed using an EMP-focused, 42 gene human-specific, nested quantitative RT-PCR assay. CTC burden varied amongst the various xenograft models with LuCaP96 having the highest number of CTCs per mouse (mean: 704; median: 31) followed by BM18 (mean: 101; median: 21), LuCaP70 (mean: 73; median: 16) and LuCaP105 (mean: 57; median: 6). A significant relationship was observed between tumour size and CTC number (
Identifiants
pubmed: 34206049
pii: cancers13112750
doi: 10.3390/cancers13112750
pmc: PMC8198708
pii:
doi:
Types de publication
Journal Article
Langues
eng
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